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the missense mutation p.Arg682His, the g.77784972T>C variant at KIT and the g.20147039C>T variant at MITF (Montrer MITF Anticorps) are the main influence on the extent of white facial markings
Accumulating mutations in series of haplotypes at the KIT and MITF (Montrer MITF Anticorps) loci are major determinants of white markings in Franches-Montagnes horses.
FGF7 (Montrer FGF7 Anticorps) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (Montrer KITLG Anticorps) signaling pathway.
c-kit is primarily expressed in the spermatogonia and spermatocytes of goat testes.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
PKC-delta (Montrer PKCd Anticorps) expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta (Montrer PKCd Anticorps) may be a potential therapeutic target for AdCCs.
Study demonstrates that an oncogenic tyrosine kinase (Montrer TXK Anticorps) mutant, KIT(D816V), can alter the transcriptional program of the transcription factor MITF (Montrer MITF Anticorps) in melanoma.
High c-kit expression is associated with small cell lung cancer.
The expression of c-Kit under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Gefitinib significantly increased cKIT expression in HPV-positive and HPV-negative head and neck squamous cell carcinoma cells whereas nilotinib and afatinib decreased cKIT expression in HPV-positive SCC (Montrer CYP11A1 Anticorps).
Our findings showed that increased expression of CD34 (Montrer CD34 Anticorps) and CD117 markers confer tumor progression and aggressiveness on prostate cancer.
A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 (Montrer CTLA4 Anticorps) blockade is synergistic.
4 different mutant (MT-KIT) KIT proteins from GIST tumors are intrinsically less stable than wild-type KIT due to proteasome-mediated degradation and abnormally localized to the endoplasmic reticulum or the Golgi complex. PKC-theta (Montrer PRKCQ Anticorps); is strongly and exclusively expressed in GISTs and interacts with intracellular MT-KIT to promote its stabilization by increased retention in the Golgi complex.
Report a new in vivo model of KIT D816V+ advanced systemic mastocytosis developed by transplantation of the human ROSAKIT D816V-Gluc (Montrer GBA Anticorps) mast cell line in NOD-SCID (Montrer PRKDC Anticorps) IL-2R gamma (Montrer IL2RG Anticorps)-/- mice, using Gaussia princeps luciferase as a reporter.
KIT D816V mutation sensitized mast cells from systemic mastocytosis patients to histone deacetylase (Montrer HDAC1 Anticorps) inhibitor mediated killing.
the presented study demonstrates that CBFB-MYH11-based MRD status during the first 3 months after allo-HCT, but not KIT mutations, can be used to identify patients with a high risk of relapse.
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
c-kit receptor tyrosine kinase
, mast/stem cell growth factor receptor
, protein kinase
, tyrosine kinase receptor homolog
, c-kit-related protein
, kit-related kinase 1
, mast/stem cell growth factor receptor-related protein Kit
, proto-oncogene tyrosine-protein kinase Kit-related protein
, tyrosine-protein kinase Kit
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
, Mast/stem cell growth factor receptor
, mast/stem cell growth factor receptor Kit
, transmembrane tyrosine kinase receptor
, proto-oncogene c-Kit
, c-kit receptor
, mast cell growth factor receptor
, proto-oncogene tyrosine-protein kinase Kit
, receptor tyrosine kinase c-kit
, c-KIT gene1
, Proto-oncogene c-Kit
, Tyrosine-protein kinase Kit
, caprine c-kit protein
, p145 c-kit
, piebald trait protein
, soluble KIT variant 1
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein