Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Human MERTK Anticorps:
anti-Mouse (Murine) MERTK Anticorps:
anti-Rat (Rattus) MERTK Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Mouse (Murine) Polyclonal MERTK Primary Antibody pour CyTOF, FACS - ABIN4899759
Nascimento, Huang, Smith, Everts, Lam, Bassity, Gautier, Randolph, Pearce: Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis. dans PLoS pathogens 2014
Show all 28 Pubmed References
Human Polyclonal MERTK Primary Antibody pour CM, ICC - ABIN2746864
Keating, Salzberg, Sather, Liang, Nickoloff, Anwar, Deryckere, Hill, Joung, Sawczyn, Park, Curran-Everett, McGavran, Meltesen, Gore, Johnson, Graham: Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase. dans Oncogene 2006
Show all 16 Pubmed References
Human Polyclonal MERTK Primary Antibody pour CyTOF, FACS - ABIN4899963
Eken, Martin, Sadallah, Treves, Schaller, Schifferli: Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages. dans The Journal of biological chemistry 2010
Show all 11 Pubmed References
Mouse (Murine) Polyclonal MERTK Primary Antibody pour FACS, WB - ABIN5012952
Ikarashi, Nakashima, Kinoshita, Sato, Nakashima, Miyazaki, Nishiyama, Yamamoto, Seki: Distinct development and functions of resident and recruited liver Kupffer cells/macrophages. dans Journal of leukocyte biology 2014
Show all 11 Pubmed References
Human Polyclonal MERTK Primary Antibody pour CM, ICC - ABIN2746860
Wu, Singh, Georgescu, Birge: A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. dans Journal of cell science 2005
Show all 9 Pubmed References
Human Monoclonal MERTK Primary Antibody pour FACS - ABIN4895670
Graham, Salzberg, Kurtzberg, Sather, Matsushima, Keating, Liang, Lovell, Williams, Dawson, Schell, Anwar, Snodgrass, Earp: Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 7 Pubmed References
Mouse (Murine) Monoclonal MERTK Primary Antibody pour FACS - ABIN4896617
Stijlemans, Cnops, Naniima, Vaast, Bockstal, De Baetselier, Magez: Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis. dans PLoS neglected tropical diseases 2015
Show all 6 Pubmed References
Human Polyclonal MERTK Primary Antibody pour ELISA, ICC - ABIN152841
Jung, Decker, Wang, Lee, Kana, Yumoto, Cackowski, Rhee, Carmeliet, Buttitta, Morgan, Taichman: Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. dans Oncotarget 2016
Show all 3 Pubmed References
Human Monoclonal MERTK Primary Antibody pour ELISA, WB - ABIN969283
McGough, Cummings: Coeliac disease: a diverse clinical syndrome caused by intolerance of wheat, barley and rye. dans The Proceedings of the Nutrition Society 2005
Show all 3 Pubmed References
Human Polyclonal MERTK Primary Antibody pour CM, ICC - ABIN2750536
Mahajan, Earp: An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. dans The Journal of biological chemistry 2004
Show all 3 Pubmed References
Mertk expression was not significantly higher in non-muscle invasive bladder cancers (MIBCs) and MIBCs, compared to normal urothelium. Loss-of-function experiments in vitro and in a mouse xenograft model showed that Mertk depletion had only a minor impact on cell viability.
activation of MerTK in human macrophages led to ERK-mediated expression of the gene encoding SERCA2, which decreased the cytosolic Ca(2+) concentration and suppressed the activity of calcium/calmodulin-dependent protein kinase II
data do not support a particular role for TAM receptors or for activated CD11b in the association of platelet-derived EVs with monocytes and granulocytes in the circulation.
MERTK expression was increased in cell lines and patient-derived xenografts treated with AXL inhibitors.
Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. We present here a comprehensive review of all reported MERTK disease causing variants with the associated phenotype
MerTK mediates STAT3-KRAS/SRC-signaling axis for glioma stem cell maintenance
Three novel loss-of-function mutations in MERTK gene were identified in Chinese patients with retinitis pigmentosa.
Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation
Authors report that SAV1, a Hippo signaling component, inhibits Akt, a function independent of its role in Hippo signaling. Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt's movement to plasma membrane. Authors further identify cancer-associated SAV1 mutations with impaired ability to bind Akt, leading to Akt hyperactivation.
The present study provides a meaningfully negative result demonstrating that rare variants in MERTK are not associated with AMD. The study also demonstrates the role of large sample size genetic studies utilizing whole-genome sequencing as a powerful tool that can resolve clinically relevant questions regarding the genetic basis of ophthalmic disease.
cooperation between CD14 and MerTK may foster the clearance of apoptotic neutrophils by human monocytes/macrophages
Patients with retinitis pigmentosa (RP) in this study were carriers of two novel allelic mutations in the MERTK gene, a missense variant in exon 17 and an approximate 91 kb genomic deletion. Mapping of the deletion breakpoints allowed molecular testing of a cohort of patients with RP with allele-specific PCR.
The targeted NGS strategy employed provides an efficient tool for RP pathogenic gene detection. This study identified a new autosomal recessive mutation in the RP-related gene MERTK, which expands the spectrum of RP disease-causing mutations
We observed that the frequency for the wild-type haplotype was higher in the control group, compared to that in the group of patients with COPD, in the subgroup analysis of current smokers, although the difference was not statistically significant
Study describes a novel cellular pathway involved in diabetic efferocytosis, wherein diabetes-induced decrease in miR-126 expression results in upregulation of ADAM9 expression that in-turn leads proteolytic cleavage of MerTK and formation of inactive soluble Mer. Decrease in MerTK phosphorylation leads to reduced downstream cytoskeletal signaling required for engulfment and thus decreases efferocytosis.
Phosphatidylserine mediated hyperactivation of Mertk.MERTK promotes epithelial cell efferocytosis in a tyrosine kinase-dependent manner.MERTK role in AKT-dependent drug resistance.
STK 11 testing can confirm those at risk of Peutz-Jeghers syndrome, who require lifelong surveillance, and possibly release those with a simple dermatosis, such as Laugier-Hunziker syndrome, from invasive and thus potentially harmful surveillance.
The broad-spectrum activity mediated by UNC2025 in leukemia patient samples and xenograft models, alone or in combination with cytotoxic chemotherapy, supports continued development of MERTK inhibitors for treatment of leukemia
The expression of MerTK and AxlTK varied according to the deposition of immunoglobulin and complements on glomeruli. Both MerTK and AxlTK expressions were increased on glomeruli and varied according to pathological classifications.
Study identified the Gas6/TAM receptor pathway with Tyro3 and Mer as novel targets in colorectal cancer.
results suggest that apoptotic cells stimulate distinct sets of signal transduction pathways via MERTK to induce either efferocytosis or proliferation
We demonstrate that Mer-mediated apoptotic cell clearance by phagocytes contributes to resolution of allergic airway inflammation, suggesting that augmenting apoptotic cell clearance is a potential therapeutic strategy for treating allergic airway inflammation.
Genetic deletion of Gas6 or Mer is protective against silica-induced lung inflammation and fibrosis in mice.
Mertk(-/-) mice showed exacerbated arthritis pathology, whereas Pros1 overexpression diminished joint pathology.
MerTK downregulates LPS-induced inflammation through SOCS1 protein without affecting phagocytosis of E. coli in macrophages.
Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.
Mer-LXRalpha signaling plays an important role in the differentiation and maintenance of marginal zone macrophages.
MerTK-deficient macrophages have defective microparticle clearance resulting in lung inflammation and injury.
These results suggest that MerTK inhibition impaired phagocytic function of the retina
MerTK does not play an essential role in the phagocytosis of S. aureus but attenuates inflammation induced by staphylococcal LTA through blocking NF-kappaB activation.
Tumor macrophage expression of Mertk is a therapeutic target to prevent tumor recurrence following radiation therapy.
Hypercapnic Acidosis Regulates Mer Tyrosine Kinase Receptor Shedding and Activity.
GC B cell-intrinsic sensing of self-RNA, but not self-DNA, from dead cells in GCs drives enhanced GC responses in Mer(-/-) mice. Mer loss in dendritic cells promotes enhanced T cell activation and proinflammatory cytokine production. Mer immunoregulatory signaling in APCs regulates B cell selection and autoimmunity. The phagocytic and immunomodulatory functions of Mer regulate GC responses preventing autoimmunity.
this study shows that viral infection sensitizes fetal membranes by MERTK Inhibition
Monocyte-induced MerTK cleavage on proreparative MHCII(LO) cardiac macrophages is a novel contributor to myocardial ischemic reperfusion injury.
evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.
these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages
the reciprocal activation of Axl and Mer receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
MER receptor tyrosine kinase
, STK kinase
, proto-oncogene c-Mer
, receptor tyrosine kinase MerTK
, tyrosine-protein kinase Mer
, Tyro 12
, proto-oncogene tyrosine-protein kinase Mer
, Receptor tyrosine tinase gene probably the gene for Rdy
, proto-oncogene tyrosine-protein kinase MER
, retinal dystrophy
, c-eyk proto-oncogene
, c-mer proto-oncogene tyrosine kinase
, tyrosine-protein kinase Mer-like