Profil protéine

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Alternative names and synonyms associated with MME

• membrane metalloendopeptidase (MME) anticorps
• membrane metallo endopeptidase (Mme) anticorps
• membrane metallo-endopeptidase (Mme) anticorps
• membrane metalloendopeptidase (Mme) anticorps

• 6030454K05Rik anticorps
• C85356 anticorps
• CALLA anticorps
• CD10 anticorps
• Nep anticorps
• Afficher tous les alias de synonymes
• neprilysin anticorps
• SFE anticorps

Protein level used designations for MME

atriopeptidase , common acute lymphocytic leukemia antigen , enkephalinase , membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) , membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) , membrane metallo-endopeptidase variant 1 , membrane metallo-endopeptidase variant 2 , neprilysin , neutral endopeptidase 24.11 , skin fibroblast elastase , common acute lymphoblastic leukemia antigen , neutral endopeptidase , neprilysin-410 short isoform , membrane metallo endopeptidase , NEP , membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase) , LOW QUALITY PROTEIN: neprilysin