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anti-Human PAK4 Anticorps:
anti-Mouse (Murine) PAK4 Anticorps:
anti-Rat (Rattus) PAK4 Anticorps:
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Bat Polyclonal PAK4 Primary Antibody pour WB - ABIN610860
Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. dans Proceedings of the National Academy of Sciences of the United States of America 1991
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Human Polyclonal PAK4 Primary Antibody pour IHC, ELISA - ABIN1002957
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. dans The international journal of biochemistry & cell biology 2002
Show all 3 Pubmed References
Human Polyclonal PAK4 Primary Antibody pour ELISA, IF - ABIN4343475
Liu, Yang, Liu, Liu, Zhang, Xu, Zhu, Xu: p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. dans Urologic oncology 2015
Human Polyclonal PAK4 Primary Antibody pour WB - ABIN4343476
Cianciola, Chung, Manor, Carlin: Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. dans Journal of virology 2017
These results implicate a novel role for PAK4 within the PI3K (Montrer PIK3CA Anticorps) pathway via interaction with p85alpha. Thus, PAK4 could be an essential player in PDAC progression representing an interesting therapeutic opportunity.
This review will discuss the emerging data highlighting the prominence of PAK4 in Pancreatic distal adenocarcinoma(PDAC) and its potential role for transforming patient management.
this series of compounds has the potential for further development as PAK4 inhibitors for anticancer activity
X-ray crystallography reveals that in addition to the canonical PAK4 CDC42 (Montrer CDC42 Anticorps)/RAC (Montrer AKT1 Anticorps) interactive binding (CRIB (Montrer SCRIB Anticorps)) domain binding to CDC42 (Montrer CDC42 Anticorps) there are unexpected contacts involving the PAK4 kinase C-lobe, CDC42 (Montrer CDC42 Anticorps), and the PAK4 polybasic region.
High PAK4 expression is associated with glioma.
These results indicate that miR485 acts as a tumour suppressor in Glioblastoma (GBM) by, at least partially, directly targeting PAK4 and regulating the AKT (Montrer AKT1 Anticorps) and ERK (Montrer EPHB2 Anticorps) signalling pathways. Thus, miR485 may be a potential target for the treatment of patients with GBM.
Study reports the overexpression of PAK4 in neuroblastoma (Montrer ARHGEF16 Anticorps) cells and, that PF-3758309, a potent PAK4 inhibitor, inhibits cell proliferation and survival in neuroblastoma (Montrer ARHGEF16 Anticorps) cells via inhibition of the MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps) pathway. These results suggest a role of PAK4 in neuroblastoma (Montrer ARHGEF16 Anticorps) development.
Methylation at cg14010619 may modify PAK4 activity, which has been implicated in cisplatin resistance in malignant cell lines
PAK4 downregulated the level of p21 (Montrer CDKN1A Anticorps) and enhanced the activity of Akt (Montrer AKT1 Anticorps) as well. And we conclude that PAK4 acts as a regulator of cell cycle (Montrer C13orf15 Anticorps) progression of vascular smooth muscle cells by mediating Akt (Montrer AKT1 Anticorps) signaling and controlling p21 (Montrer CDKN1A Anticorps) levels, which further modulate intimal hyperplasia and vascular smooth muscle cells proliferation
Findings revealed a novel function of PAK4 in thyroid stimulating hormone-induced papillary thyroid cancer progression.
PAK4 crystal structures can be classified into specific conformational groups, and that these groups are associated with previously unobserved hinging motions and an unusual conformation for the kinase hydrophobic core. Our findings therefore indicate that there may be a diversity of kinase hinging motions, and that these may indicate different mechanisms of regulation.
PAK4 microparticles may have a role in the ventilation-induced lung injury process
These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.
PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (Montrer CREB1 Anticorps) and Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.
PAK4 phosphorylates Par6B (Montrer PARD6B Anticorps) at Ser143 blocking its interaction with Cdc42 (Montrer CDC42 Anticorps).
Defined here is the overlap in phosphopeptides regulated by K-Ras (Montrer HRAS Anticorps), Cdc42 (Montrer CDC42 Anticorps), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.
These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart
p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.
the transient increase in PAK4 levels at early G1 reduces p21 (Montrer D4S234E Anticorps) levels, thereby abrogating the activity of CDK4 (Montrer CDK4 Anticorps)/CDK6 (Montrer CDK6 Anticorps) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way
Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.
pak4 is dispensable in zebrafish.
Zebrafish pak4 is required for primitive myeloid cell development.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, p21(CDKN1A)-activated kinase 4
, p21-activated kinase 4
, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
, serine/threonine-protein kinase PAK 4
, p21 (CDKN1A)-activated kinase 4
, p21 protein (Cdc42/Rac)-activated kinase 4