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Human PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN413706
Tsuchida, Schneider, Pizani, Oliveira: Lead and aluminum bonding in Pb-AI metaphosphate glasses. dans Inorganic chemistry 2008
Mouse (Murine) PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN413709
Hamada, Gonda, Takeda, Sato, Watanabe, Yambe, Satomi, Ohuchi: In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia. dans Blood 2011
Human PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN804609
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Human PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN1589629
Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. dans Diabetes 2015
we further demonstrated that this aberrant cell phenotype is reversed by the platelet-derived growth factor (PDGF) BB, indicating that PDGF signaling is a key regulator of MSC functionality. These findings provide an attractive approach to improve the therapeutic efficacy of MSCs in autologous therapy for diabetic patients.
Study demonstrates that breast cancer cells secrete CXCL17, which increases the accumulation of CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) in the lungs. CXCL17 increases MDSCs PDGF-BB secretion which contributes to MDSC-mediated angiogenesis in the lung metastatic niche and colonization of breast cancer. Patients with high levels of CXCL17 have shorter distant metastasis-free and overall survival rates.
the effect of selective ERalpha and ERbeta modulators on platelet-derived growth factor (PDGF)-stimulated airway smooth muscle proliferation and the mechanisms involved, were investigated.
In regards to extracellular matrix remodelling, treprostinil significantly reduced PDGF-BB-TGF-beta1-CTGF induced synthesis and deposition of collagen type I and fibronectin, in a cAMP sensitive manner
In thoracic dissection elevated expression of PDGF-B induces deposition of collagen, disrupts extracellular matrix homeostasis, and increases the stiffness of the aorta wall, resulting in compromised aorta compliance.
In vivo, the expression of VEGF-A and PDGF-B was significantly upregulated at full-thickness foot dorsal skin wounds and the area of ulceration was progressively and significantly reduced following treatment with nanosphere/plasmid.
Nine of 11 dermatofibrosarcoma protuberans tumors (82%) had rearrangement of PDGFB by fluorescence in situ hybridization.
we identified two potential susceptibility loci for PC risk, which are located in PDGFB at 22q13.1
Treating HepG2 cells with hepatotoxicants resulted in a significant increase in mRNA expression of platelet-derived growth factor BB (PDGF-BB) and transforming growth factor beta (TGFbeta).
The morphology and immunophenotype of all 6 cases was analogous to those with the canonical COL1A1-PDGFB fusion; none of the cases showed fibrosarcomatous transformation. This study illustrates that the COL6A3-PDGFD fusion product is rare in dermatofibrosarcoma protuberans, and associated with an apparent predilection for breast
PDGF-B expression was found in ovarian tumor microvessels in 72% of cases. High expression of PDGF in pericapillary cells was strongly associated with high expression of this marker in cancer cells. Significant correlations between PDGF-B and nestin expression in malignant tumor microvessels were also found.
SOX7 transcription factor mediates PDGF-BB-induced IL-33 expression.
High expression of PDGF-BB may be involved in the pathogenesis of Graves' disease. CCR2-positive macrophages may induce the expression of PDGF-BB through HIF-1alpha signal.
rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway, indicating that rhPDGF-BB combined with ADSCs could treat Achilles tendinitis via miR-363/PI3K/Akt pathway.
This study identifies the mbPDGF-BB in cell derived extracellular vesicles as a relevant mediator of diabetes-associated vascular smooth muscle cell resistance to apoptosis.
This review showed that PDGFB was one of the common gene involved included with brain calcification.
Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB gene to the collagen 1A1 gene.
Transglutaminase type 2 affects cell migration through post-translational modification of PDGF-BB.
PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to severe fever with thrombocytopenia syndrome in Chinese individuals.
PDAP-1 as an effecter of PDGF signaling in glioma cells
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
Data indicate that ERas/PDGFbetaR complex could play a role in the pathogenesis of bovine papillomavirus-associated bladder neoplasia.
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt/Stat3 signaling pathway.
These results provide strong genetic evidence that the transmembrane domains of the E5 protein of bovine papillomavirus 1 and the platelet-derived growth factor beta receptor contact one another directly.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
The effect of loud sound on pericytes is mediated by upregulation of PDGF-BB. Normal functioning pericytes are required for vascular stability.
the importance of PDGF-B regulatory network in prostate cancer progression.
microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the atherosclerotic phenotype.
The PDGFB-overexpressing murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA-amplified at both the RNA and protein expression levels. These models can be generated in fully immunocompetent mixed or C57BL/6 genetic background mice, and therefore can easily be incorporated into preclinical studies for cancer cell-specific or immune cell-targeting drug discovery studies.
Myeloid cell-derived PDGF contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.
These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS, NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF, FGF-2 and PDGF-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Increased expression of STAT5b + PDGFB led to increased expression of downstream STAT5b targets.
Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2-null mice.
The endogenous levels of PDGF-BB, increases CD31(hi)endomucin(hi) vessel number and stimulates bone formation in ovariectomy mice.
These findings thus implicate a novel role of PDGF-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier
The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination
The signaling pathways of VEGF and PDGF are crucial mediators for determining proliferation of endothelial cells and oligodendrocytes in the neurohypophysis of adult mice.
Our findings demonstrate, for the first time, that Shh is involved in PDGF-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels
Tumor PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis.
Data indicate a significant impairment of the activation mechanisms by PDGF-BB was shown after a hammerhead ribozyme targeting the membrane receptor PDGFR-beta was applied.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit
, Platelet-derived growth factor B chain