Aperçu des produits pour anti-Phospholipase C gamma 1 (PLCG1) Anticorps

Human phospholipase C, gamma 1 (PLCG1) interaction partners

1. novel insight into autophagy regulation by PLCgamma1 in colon cancer and hepatocellular carcinoma cells

2. In pancreatic cancer (PC) tissue samples expression of TSPAN1 was markedly increased compared to normal samples. siRNA knockdown of TSPAN1 in PC cell lines suppressed PC cell migration and invasion and downregulated MMP2 expression. Transfection with siRNA targeted to PLCgamma revealed that TSPAN1 siRNA suppressed PC cell migration and invasion, and MMP2 expression by blocking the translocation and phosphorylation of P...

3. the forced expression of FGFR2b signalling mutants and the use of specific inhibitors of FGFR2b substrates showed that the receptor-triggered autophagy requires PLCgamma signaling.

4. Data suggest that FGFR3 with mutation found in SADDAN (but not FGFR3 with mutation found in TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin; binding of FGFR3 to PLCG1 appears to be involved. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II)

5. PLCgamma2 plays a critical role for Ca(2+) Flux in HCECs stimulated by A. fumigatus hyphae. Syk acts upstream of PLCgamma2 in the Dectin-1 signaling pathway.

6. a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex.

7. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis.

8. PLCG1, along with ITGA4 are regulated by miR-30b in clinical samples of coronary artery cells from coronary atherosclerosis patients.

9. the central biological role of the novel IL-2-R/Lck/PLCgamma/PKCtheta;/alphaPIX/Rac1/PYGM signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.

10. LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity

11. Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)

12. The products of PLC-gamma activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. (Review)

13. 1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by a ff ;ecting the VDR/PLC-gamma1/TGF-beta1pathway. These results indicate that administration 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients.

14. Results show that PLCgamma-1 activation enhanced skin cell transformation.

15. These results suggest that immobilized EGF increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR trafficking and PLCgamma1 activation.

16. High FLC gamma expression is associated with Radioresistance in Glioblastoma.

17. High PLC gamma expression is associated with breast cancer.

18. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. As well as defining a novel mechanism of Akt phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2, Plc11 and Grb2 correlate with patient survival

19. the PLCgamma-1 signaling plays an important role in the H1N1-induced inflammatory responses. Our study suggests that targeting the PLCgamma-1 signaling is a potential antiviral therapy against H1N1 by inhibiting both viral replication and excessive inflammation.

20. These results indicate that PP1 is recruited to the extracellular calcium-dependent E-cadherin-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC-g1 activation leading to keratinocyte differentiation.

Cow (Bovine) phospholipase C, gamma 1 (PLCG1) interaction partners

1. This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.

2. Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2+ flux, NF-AT and AP-1 activation.

3. PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homology (SH2C) domain.

Mouse (Murine) phospholipase C, gamma 1 (PLCG1) interaction partners

1. Plcg-1 promotes axon extension and guidance by mediating netrin-1/DCC signaling.Netrin-1 activates the lipase activity ofPlcg-1 through phosphorylation of the Y783-residue by Src kinase.Plcg-1 is a crucial molecule mediating the directional movement of axons that are regulated by netrin-1/DCC signaling during brain development.

2. High PLCG1 expression is associated with pulmonary hypertension.

3. results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.

4. Smooth muscle PLCgamma1-Akt-mediated Notch1 signaling is crucial for intima formation in vascular injury.

5. Findings provide evidence that PLCgamma1 is critical for synaptic function and plasticity and that the loss of PLCgamma1 from the forebrain results in manic-like behavior.

6. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis.

7. our studies demonstrate that PLCgamma1 is important for pre-TCR mediated signal transduction and pre-T cell development.

8. Knock-down of PLC-gamma-1 induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1-transfected cells strongly inhibited foreign body giant cell formation.

9. study shows that PLCgamma1 controls osteoclast numbers via a CSF-1-dependent DAG/beta-catenin/cyclinD1 pathway.

10. this study shows that PLC-gamma1 contributes to protective activity of LAT activity in vivo

11. PLCgamma1 signaling is involved in the formation of neuronal processes for functionally faithful brain development. [review]

12. FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.

13. platelet activation through GPVI and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2.

14. foci are polymerized de novo as a result of the T cell receptor (TCR) proximal tyrosine kinase cascade, and facilitate distal signaling events including PLCgamma1 activation and subsequent cytoplasmic calcium ion elevation

15. The result indicate that LAT-PLCg1 interaction is important for controlling IL-6 production by T cells and demonstrate a critical role of IL-6 in the development of the lymphoproliferative syndrome.

16. low level of LAT-PLC-gamma1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.

17. These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 in Dow2-induced anergic T cells. The novel CD3-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression

18. Membrane tethering of PKCdelta leads to increased force exertion on extracellular matrix through PLCgamma1/EGFR signaling.

19. EAT-2 mediates its effects in natural killer cells by linking SLAM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase.

20. Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1) signaling may function differently in various subsets of gammadelta T cells.

Zebrafish phospholipase C, gamma 1 (PLCG1) interaction partners

1. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish

2. muscle of the heart uses the VEGF-PLCgamma1 cascade to control the strength of the heart beat

3. genetic analyses suggest that Vegf/Plcg1 signaling acts at multiple time points and in different signaling contexts to mediate distinct aspects of artery development