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anti-Mouse (Murine) Phospholipase C gamma 2 Anticorps:
anti-Rat (Rattus) Phospholipase C gamma 2 Anticorps:
anti-Human Phospholipase C gamma 2 Anticorps:
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Human Polyclonal Phospholipase C gamma 2 Primary Antibody pour IHC - ABIN966863
Kim, Sekiya, Poulin, Bae, Rhee: Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. dans Molecular and cellular biology 2004
Show all 2 Pubmed References
Human Polyclonal Phospholipase C gamma 2 Primary Antibody pour IF (p), IHC (p) - ABIN700375
Diaz-Flores, Goldschmidt, Depeille, Ng, Akutagawa, Krisman, Crone, Burgess, Williams, Houseman, Shokat, Sampath, Bollag, Roose, Braun, Shannon: PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. dans Science signaling 2013
Human Monoclonal Phospholipase C gamma 2 Primary Antibody pour ICS - ABIN1177150
Holodick, Tumang, Rothstein: Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells. dans Molecular immunology 2009
Syk (Montrer SYK Anticorps)-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (Montrer PLC Anticorps) gamma1 (PLCgamma1 (Montrer PLCG1 Anticorps)) in osteogenesis and PLCgamma2 in adipogenesis.
Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines.
PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice
platelet activation through GPVI (Montrer GP6 Anticorps) and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 (Montrer PLCG1 Anticorps) levels are insufficient to support responsiveness, but that PLCgamma1 (Montrer PLCG1 Anticorps) can restore responsiveness if expressed at levels normally achieved by PLCgamma2.
amarogentin prevents platelet activation through the inhibition of PLC (Montrer HSPG2 Anticorps) gamma2-PKC cascade and MAPK (Montrer MAPK1 Anticorps) pathway
PLCgamma2 and protein kinase C are important upstream signals that regulate myelopoiesis through cytokines.
inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 (Montrer MYO15 Anticorps) domains of PLCgamma2.
down-regulation of PLCgamma2-beta-catenin (Montrer CTNNB1 Anticorps) pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion.
a novel role of the PLCgamma2-IP(3)-Ca(2 (Montrer CA2 Anticorps)+) cascade in the LPS (Montrer TLR4 Anticorps)-induced innate immune response pathway where release of intracellular Ca(2 (Montrer CA2 Anticorps)+) mediates TLR4 (Montrer TLR4 Anticorps) trafficking and subsequent activation of IRF3 (Montrer IRF3 Anticorps).
VapB (Montrer VAPB Anticorps) positively regulates RANKL (Montrer TNFSF11 Anticorps)-mediated osteoclastogenesis via PLCgamma2-Ca(2 (Montrer CA2 Anticorps)+)-NFAT (Montrer NFATC1 Anticorps) signaling
finding that mutations or polymorphisms in two putative calcium-regulated domains of PLCG2 are associated with ibrutinib-resistant CLL adds to the evidence supporting complex regulatory shifts in the PLCG2 protein likely occurring during the development of resistance
Data show that protein-altering changes are in PLCG2, ABI3 (Montrer ABI3 Anticorps), and TREM2 (Montrer TREM2 Anticorps) genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC (Montrer HSPG2 Anticorps)[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1 (Montrer IL1A Anticorps)[beta]).
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR (Montrer BCR Anticorps) and converging on PLCgamma2 through Rac (Montrer AKT1 Anticorps) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL).
Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells.
amarogentin prevents platelet activation through the inhibition of PLC (Montrer HSPG2 Anticorps) gamma2-PKC (Montrer PRRT2 Anticorps) cascade and MAPK (Montrer MAPK1 Anticorps) pathway
PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood.
The autoinhibitory C-terminal SH2 domain of phospholipase C (Montrer PLC Anticorps)-gamma2 stabilizes B cell receptor signalosome assembly.
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
, phosphoinositide phospholipase C-gamma-2
, phospholipase C-gamma-2
, phosphoinositide phospholipase C
, phospholipase C-IV
, phosphatidylinositol-specific phospholipase C