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anti-Human Ret Proto-Oncogene Anticorps:
anti-Mouse (Murine) Ret Proto-Oncogene Anticorps:
anti-Rat (Rattus) Ret Proto-Oncogene Anticorps:
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Human Polyclonal Ret Proto-Oncogene Primary Antibody pour WB - ABIN1882126
Siqueira, Romitti, da Rocha, Ceolin, Meotti, Estivalet, Puñales, Maia: The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma. dans Endocrine-related cancer 2010
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Human Polyclonal Ret Proto-Oncogene Primary Antibody pour IHC (p), IHC - ABIN238908
Bergelin, Löf, Balthasar, Kalhori, Törnquist: S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. dans Endocrinology 2010
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Human Polyclonal Ret Proto-Oncogene Primary Antibody pour ELISA - ABIN544339
DAlessio, Califano, Incoronato, Santelli, Florio, Schettini, Carlomagno, Cerchia, de Franciscis: The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants. dans Endocrinology 2003
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Human Monoclonal Ret Proto-Oncogene Primary Antibody pour ELISA, WB - ABIN1724684
Young, Anderson, Anderson: Guidance cues involved in the development of the peripheral autonomic nervous system. dans Autonomic neuroscience : basic & clinical 2004
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Human Monoclonal Ret Proto-Oncogene Primary Antibody pour ELISA, WB - ABIN1724678
Myers, Mulligan: The RET receptor is linked to stress response pathways. dans Cancer research 2004
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Human Polyclonal Ret Proto-Oncogene Primary Antibody pour ICC, IF - ABIN4350058
Luo, Tsuchiya, Il Park, Fausel, Kanngurn, Welcsh, Dzieciatkowski, Wang, Grady: RET is a potential tumor suppressor gene in colorectal cancer. dans Oncogene 2013
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Human Monoclonal Ret Proto-Oncogene Primary Antibody pour CyTOF, FACS - ABIN4900140
Fonseca-Pereira, Arroz-Madeira, Rodrigues-Campos, Barbosa, Domingues, Bento, Almeida, Ribeiro, Potocnik, Enomoto, Veiga-Fernandes: The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. dans Nature 2014
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Human Polyclonal Ret Proto-Oncogene Primary Antibody pour IHC (p), WB - ABIN392038
Takaki, Nakayama, Misawa, Nakagawa, Kuniyasu: In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. dans Stem cells (Dayton, Ohio) 2006
Human Polyclonal Ret Proto-Oncogene Primary Antibody pour WB - ABIN392039
de Martimprey, Bertrand, Fusco, Santoro, Couvreur, Vauthier, Malvy: siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma. dans Nucleic acids research 2008
Authors observed no interaction between efn-A5b and RET from zebrafish, this lack of association indicates how complex efn-A signaling is and suggests that there may be other molecules involved in efn-A5-induced RET signaling.
These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.
Significantly, we show that introduction of mapk10 mutations into ret heterozygotes enhanced the ENS deficit, supporting MAPK10 as a Hirschsprung disease (HSCR) susceptibility locus. Our studies demonstrate that ret heterozygous zebrafish is a sensitized model, with many significant advantages over existing murine models, to explore the pathophysiology and complex genetics of HSCR.
RET expression is investigated within the brain of zebrafish; both RET protein and mRNA are observed.
In animals lacking Ret or Gfra3 function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.
evaluation of noncoding sequences at the zebrafish ret locus conserved among teleosts, and at the human RET locus, conserved among mammals
genes beyond RET may be implicated in the genesis of sporadic cases of HD
RET-mTORC1 signaling promotes AML through autophagy suppression.
When grouped by mutational risk (highest; high; moderate-high; low-moderate; polymorphism), the age-related progression of MTC was significant for all four categories of RET mutations, which differed significantly across and within the three histopathological groups.
We emphasize that novel approaches to targeting RET-dependent tumours are necessary to improve the clinical efficacy of single-agent multikinase inhibition and, thus, hasten approvals of RET-directed targeted therapies
results affirmed that RET mutation is a reliable molecular biomarker to identify a group of highly aggressive sporadic medullary thyroid carcinoma (meta-analysis)
We confirmed the co-expression of RET and ER, but we did not find RET expression to be an independent prognostic factor in human breast cancer
Combinations of rare variants and the common non-coding RET variant cause the majority of the Hirschsprung disease cases in the studied population.
Report occurrence of RET gene rearangements in intraductal carcinomas of salivary gland.
Report molecular analysis of a group of mammary analog secretory carcinomas harboring a novel ETV6-RET translocation.
The role of tumor microenvironment, inflammation and NF-kappaB and RET genes expression regulation in the initiation and development of papillary thyroid carcinoma was shown. (Review)
A new RET gene mutation was identified causing Hirschsprung disease in an induced pluripotent cell line from a patient carrying the RET mutation.
we analyzed an apparently sporadic medullary thyroid carcinoma harboring a somatic RET c.1900T>C mutation [p.Cys634Arg] in a previously healthy 29-year-old man. NGS data showed that the synonymous substitution was in cis with the somatic RET p.Cys634Arg driver mutation, and subsequent experiments demonstrated that it exerted appreciable effects on RET pre-mRNA splicing.
we detected RET gene rearrangements in 384 patients with advanced primary NSCLC by RT-PCR and found a RET gene rearrangement rate of 1.82%. We also found a higher prevalence of RET gene rearrangements in primary compared with metastatic lesions (chi2=91.117, P<0.001). The presence of RET rearrangement in the primary tumor could be predicted by rearrangement in the corresponding metastatic lesion (kappa=0.798, P<0.001)
mutation was found in 23.8% of hereditary medullary thyroid carcinoma patients tested; most commonly mutated codon was codon 634 (37.1%), followed by codon 918 (14.3%)
Novel low frequency SNP in ERT locus is associated with Hirschsprung disease.
RET alterations, such as RET-oncogene fusions, are present in a subset of breast cancers, and are promising therapeutic targets.
RET gene alterations (copy number gain and rearrangement) exist in all RET-positive samples. RET-positive expression is a relatively independent factor in non-small cell lung cancer cases(NSCLC) patients, which indicates that the RET gene may be a novel target site for personalized treatment of NSCLC.
Somatic mutations of the RET gene are underrecognized in HSCR. Molecular investigation of the parents of patients with seemingly sporadic mutations is essential to determine recurrence risk in these families.
in vitro transactivation of the RET promoter by different Hirschsprung disease-associated PHOX2B polyA variants has resulted significantly lower compared to the effect of PHOX2B wild type protein.
These results support the association between genetic variation of RET and NRG1 and susceptibility to Hirschsprung disease in the Chinese population.
the results from three transcriptome-based platforms (Nanostring Elements, Agena LungFusion panel and ThermoFisher NGS fusion panel) were compared to those obtained from ALK, ROS1 and RET Fluorescence In Situ Hybridization on 51 clinical specimens.
Immunohistochemistry and random sparse recombination coupled with histochemical AP staining provided an in-depth characterization of retinal ganglion cells (RGCs), horizontal cells (HCs) and amacrine cells (ACs) expressing RET. Ret is expressed in at least three distinct types of ACs, and ten types of RGCs. Ret expression overlaps with Brn3a in 4 RGC types, with Brn3b in 5 RGC types, and with Brn3c in one RGC type.
An oncogenic role of non-mutated Ret in the mammary gland.
p75 is required for the development of the nonpeptidergic nociceptor lineage by fine-tuning Ret-mediated trophic support.
7-DHC efficiently supports Ret signaling in vitro.
Results showed that Mn-mediated age-related hearing loss involved a decreased expression and phosphorylation levels of c-Ret in spiral ganglion neurons.
Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRalpha1 or RET Impairs Normal Cerebellar Motor Learning
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase.
Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases.
Authors did not find evidence for genetic interaction between Ret and Sema3d affecting survival, presence of myenteric plexus or intestine transcriptome.
findings uncover a novel spinal circuit that mediates crosstalk between touch and pain pathways and suggest that some early RET positive Dorsal Horn neurons could function as pain "gating" neurons.
Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.
we described a RET-ER81-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes.
Ret and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.
Parkin and the RET signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars compacta dopaminergic neurons and their innervation in the striatum.
the Ret signaling pathway is important for podocyte survival and recovery from glomerular injury in vivo
RET coupling to ERK and Akt depends strongly on artemin concentration, and it is highest at the low (~100 pM) artemin levels required for neurite outgrowth.
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
proto-oncogene tyrosine-protein kinase receptor Ret
, receptor tyrosine kinase
, ret proto-oncogene
, proto-oncogene tyrosine-protein kinase receptor Ret-like
, RET transforming sequence
, cadherin family member 12
, cadherin-related family member 16
, hydroxyaryl-protein kinase
, proto-oncogene c-Ret
, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
, Ret gene for receptor tyrosin
, Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)
, ret tyrosine kinase