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anti-Human RYK Anticorps:
anti-Mouse (Murine) RYK Anticorps:
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Human Polyclonal RYK Primary Antibody pour IHC (p), WB - ABIN392050
Miyashita, Koda, Kitajo, Yamazaki, Takahashi, Kikuchi, Yamashita: Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury. dans Journal of neurotrauma 2009
Show all 4 Pubmed References
Human Polyclonal RYK Primary Antibody pour IHC (p), WB - ABIN392051
Keeble, Halford, Seaman, Kee, Macheda, Anderson, Stacker, Cooper: The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Show all 2 Pubmed References
Mouse (Murine) Polyclonal RYK Primary Antibody pour CyTOF, FACS - ABIN4900273
Povinelli, Nemeth: Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor. dans Stem cells (Dayton, Ohio) 2014
RYK and VANGL2 proteins form a complex, whereas RYK also activated RhoA, a downstream effector of PCP signaling.
Data suggest that full-length Ryk conveys Wnt5b signals in a directional manner during gastrulation.
appears to signal predominantly through non-canonical WNT-triggered pathways including the PCP and WNT/Ca2+ pathways [review]
our findings demonstrate that Ryk promotes stem cell-like and tumorigenic features to glioma cells its essential for the maintenance of glioblastoma stem cells
Wnt5A/Ryk signaling might provide novel therapeutic strategies to prevent capillary leakage in systemic inflammation and septic shock.
results corroborated previous findings of Ryk-mediated Wnt5a effect, and suggested a role for Ror2 in the Wnt5a machinery in glioblastoma
Early treatment with HGF/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling
Ryk-intracellular domain pathway may impair FOXO protective activity in mutant polyglutamine neurons, suggesting neurons unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in Huntington disease
is a candidate wnt5a receptor.
The Ryk is important for the Wnt-5a-dependent induction of MMP-2 and invasive activity in glioma-derived cells and that Ryk might have a novel patho-physiological function in adult cancer invasion.
RYK interacts both physically and functionally with the E3 ubiquitin MIB1. MIB1 is sufficient to activate Wnt/CTNNB1 signaling and this activity depends on endogenous RYK.
RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.
a missense mutation, 1355G>A, and one rare single nucleotide polymorphisms haplotype may play a role in the development of cleft lip and/or palate in the Vietnamese, and cleft lip and/ or palate and cleft palate only in the Japanese
validated occurrence of an unusual TG 3' splice site in intron 7
These findings reveal an essential role for Ryk in regulating dendrite complexity.
Smek1 and Smek2 (Smek1/2) are key factors in the Ryk signaling pathway
reveal a novel function of Ryk signaling in controlling motor cortex remapping after spinal cord injury in adulthood.
Ryk deficiency in hematopoietic stem cells from fetal liver reduces their quiescence, leading to proliferation-induced apoptosis and decreased self-renewal.
Wnt5a regulates HSC quiescence and hematopoietic repopulation through the Ryk receptor and that this process is mediated by suppression of reactive oxygen species.
Ryk inhibits axonal growth in response to Wnt5a.
Ryk is an important mediator of ventral midbrain dopaminergic neuron development.
Ryk regulates Wnt5a signaling and planar cell polarity by modulating the degradation of Vangl2.
Results identify Ryk as a multi-functional receptor that is able to transduce extrinsic cues into progenitor cells, promote GABAergic neuron formation, and inhibit oligodendrogenesis during ventral embryonic brain development.
Mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands.
RYK regulates cell migration during mammalian cortical development through the binding to Eph receptors
Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient
summary, this study expands the emerging role for Wnts in axon guidance and identifies Ryk as a key guidance receptor in the establishment of the corpus callosum.
Results demonstrate an unexpected mechanism of Ryk as a Wnt receptor, where the intracellular domain itself functions as the transducing molecule to bring signals from the cell surface into the nucleus, to regulate neural cell differentiation.
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
RYK receptor-like tyrosine kinase
, tyrosine kinase RYK
, ryk receptor-like tyrosine kinase
, receptor-like tyrosine kinase
, tyrosine-protein kinase RYK
, tyrosine kinase-related protein
, tyrosine-protein kinase RYK-like
, JTK5A protein tyrosine kinase
, hydroxyaryl-protein kinase
, growth factor receptor
, kinase VIK
, met-related kinase