Aperçu des produits pour anti-SHC1 (SHC1) Anticorps

Human SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. STAT4 (Montrer STAT4 Anticorps) is a novel transcriptional regulator of p66Shc in normal and chronic lymphocytic leukemia B cells

2. Isoform b of DDR1 (Montrer DDR1 Anticorps) is responsible for collagen I-induced up-regulation of N-cadherin (Montrer CDH2 Anticorps) and tyrosine 513 of DDR1b is necessary.

3. NIC (Montrer NCSTN Anticorps) exacerbated AZA-dependent injury via augmenting p66shc transcription. While RES suppressed NIC (Montrer NCSTN Anticorps)+AZA-mediated injury, -surprisingly-it further enhanced activity of the p66shc promoter. RES protected cells via the cytoplasmic p66shc/Nrf2 (Montrer GABPA Anticorps)/heme oxygenase-1 (HO-1 (Montrer HMOX1 Anticorps)) axis

4. The results show that the interaction between STS-1 (Montrer STS1 Anticorps) and ShcA is regulated in response to EGF receptor (Montrer EGFR Anticorps) activation.

5. Nox4 (Montrer NOX4 Anticorps)-derived H2O2 in part activates Nox2 (Montrer CYBB Anticorps) to increase mitochondrial ROS (Montrer ROS1 Anticorps) via pSer36-p66Shc, thereby enhancing VEGFR2 (Montrer KDR Anticorps) signaling and angiogenesis in endothelial cells.

6. Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (Montrer POLD3 Anticorps)CA (p66) activation invol (Montrer SIGLEC1 Anticorps)ving Ser(139) and a motif surroun (Montrer SIGLEC1 Anticorps)ding Ser(213).

7. Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (Montrer POLD3 Anticorps) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.

8. regulates the alternative splicing of XAF1 (Montrer XAF1 Anticorps) in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death

9. The silence of p66(Shc) in HCT8 cells reduced the proliferation and accelerated the apoptosis, in addition, the expression of pro-apoptotic proteins caspase-3 (Montrer CASP3 Anticorps), caspase-9 (Montrer CASP9 Anticorps), Bax (Montrer BAX Anticorps) was enhanced and the expression of anti-apoptotic protein Bcl-2 (Montrer BCL2 Anticorps) was declined.

10. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (Montrer INS Anticorps) resistance.

Zebrafish SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.

Xenopus laevis SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. ShcA is required for Wnt-5a (Montrer WNT5A Anticorps)/Ror2 (Montrer ROR2 Anticorps) mediated upregulation of xPAPC (Montrer PCDH8 Anticorps), which demonstrates the functional relevance of this interaction.

Cow (Bovine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (Montrer CAT Anticorps).

2. p66shc, but not p53 (Montrer TP53 Anticorps), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.

3. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos

4. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.

Mouse (Murine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. P66Shc, a key regulator of metabolism and mitochondrial ROS (Montrer ROS1 Anticorps) production, is dysregulated by mouse embryo culture

2. The results indicate that Shc proteins should be considered as potential targets for developing interventions to mitigate weight gain on high-fat diet by stimulating energy expenditure.

3. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (Montrer MLXIP Anticorps)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (Montrer SIRT1 Anticorps).

4. p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.

5. Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (Montrer POLD3 Anticorps) activation involving Ser (Montrer SIGLEC1 Anticorps)(139) and a motif surrounding Ser (Montrer SIGLEC1 Anticorps)(213).

6. JNK1 (Montrer MAPK8 Anticorps)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.

7. Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (Montrer HADHB Anticorps) ACAA2 (Montrer ACAA2 Anticorps), to which p46Shc binds directly and with a strong affinity.

8. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (Montrer INS Anticorps) resistance.

9. p53 (Montrer TP53 Anticorps)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity

10. Silencing of p66(Shc) restored insulin (Montrer INS Anticorps) response via IRS-1 (Montrer IRS1 Anticorps)/Akt (Montrer AKT1 Anticorps)/eNOS (Montrer NOS3 Anticorps) pathway. Its knockdown in endothelial cells from Ob/Ob mice lessened ROS (Montrer ROS1 Anticorps) production, FFA oxidation, and dysregulation of redox-sensitive pathways.