anti-Humain SHC1 anticorps pour Immunohistochemistry (Frozen Sections)

Recommended SHC1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Anticorps
  • SHC1
  • SHC
  • SHCA
  • P66shc
  • si:dkey-246i14.4
  • wu:fc10h03
  • shc
  • p66shc
  • Shc
  • ShcA
  • p66
  • SHC adaptor protein 1
  • Shc1p
  • squalene--hopene cyclase
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC (Src homology 2 domain containing) transforming protein 1 L homeolog
  • src homology 2 domain-containing transforming protein C1
  • SHC1
  • shc1
  • Shc1
  • shc1.L
Épitope
AA 536-564, C-Term
43
41
19
17
15
15
14
10
10
7
7
6
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
233
181
140
10
6
5
2
2
1
1
1
1
1
Hôte
Lapin
215
30
Clonalité
Polyclonal
Conjugué
Cet anticorp SHC1 est non-conjugé
7
7
6
5
5
5
5
5
5
5
5
5
5
5
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
172
83
66
61
47
37
14
8
6
5
4
3
1
1
Options
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N° du produit ABIN3043923
$ 280.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN126888 EIA IHC (fro) WB Mouse IgG1 pTyr239, pTyr240 Connectez-vous pour afficher 1-00E-003 0
1 ABIN126889 IHC (fro) WB Mouse IgG1 pTyr317 Connectez-vous pour afficher 1-50E-012 0
1 ABIN126887 IHC (fro) IF WB Mouse IgG1 C-Term Connectez-vous pour afficher 11F6 0
1 ABIN3044111 ICC IHC (fro) IHC (p) WB Rabbit IgG AA 424-440, C-Term Connectez-vous pour afficher Polyclonal 0
1 ABIN3032555 ICC IHC (fro) IHC (p) WB Rabbit IgG C-Term Connectez-vous pour afficher Polyclonal 0
1 ABIN4952550 IHC (fro) IHC (p) WB Rabbit IgG Connectez-vous pour afficher Polyclonal 0

General

Antigène SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Anticorps
Épitope AA 536-564, C-Term
(43), (41), (19), (17), (15), (15), (14), (10), (10), (7), (7), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(233), (181), (140), (10), (6), (5), (2), (2), (1), (1), (1), (1), (1)
Hôte Lapin
(215), (30)
Clonalité
Polyclonal
Conjugué Cet anticorp SHC1 est non-conjugé
(7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(172), (83), (66), (61), (47), (37), (14), (8), (6), (5), (4), (3), (1), (1)
Fournisseur Connectez-vous pour afficher

Détail du produit anti-SHC1 anticorps

Détail du antigène SHC1 Information d'application Stockage Images
Fonction Rabbit IgG polyclonal antibody for SHC-transforming protein 1(SHC1) detection. Tested with WB, IHC-P, IHC-F in Human,Mouse,Rat.
Séquence VDPEGVVRTK DHRFESVSHL ISYHMDNHL
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for SHC-transforming protein 1(SHC1) detection. Tested with WB, IHC-P, IHC-F in Human,Mouse,Rat.
Gene Name: SHC (Src homology 2 domain containing) transforming protein 1
Protein Name: SHC-transforming protein 1
Purification Immunogen affinity purified.
Immunogène A synthetic peptide corresponding to a sequence at the C-terminus of human SHC (536-564aa VDPEGVVRTKDHRFESVSHLISYHMDNHL), identical to the related mouse and rat sequences.
Isotype IgG

Détail du antigène SHC1

Détail du produit anti-SHC1 anticorps Information d'application Stockage Images Haut de la page
Antigène
Autre désignation SHC1 (SHC1 Antibody Extrait)
Sujet SHC, also known as SHC1 (SHC-transforming protein 1) or SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: FLJ26504 antibody|MGC98812 antibody|p46 antibody|p52 antibody|p52 SHC antibody|p52SHC antibody|p66 antibody|p66 SHC antibody|p66SHC antibody|SH2 domain protein C1 antibody|SHC (Src homology 2 domain containing) transforming protein 1 antibody|SHC 1 antibody|SHC A antibody|Shc antibody|SHC transforming protein 1 antibody|SHC transforming protein antibody|SHC-transforming protein 1 antibody|SHC-transforming protein 3 antibody|SHC-transforming protein A antibody|SHC1 antibody|SHC1_HUMAN antibody|SHCA antibody|Src homology 2 domain containing transforming protein C1 antibody|Src homology 2 domain-containing-transforming protein C1 antibody
ID gène 6464
UniProt P29353
Pathways Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2

Information d'application

Détail du produit anti-SHC1 anticorps Détail du antigène SHC1 Stockage Images Haut de la page
Indications d'application WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat , The detection limit for SHC is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions For Research Use only

Stockage

Détail du produit anti-SHC1 anticorps Détail du antigène SHC1 Information d'application Images Haut de la page
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Images

Détail du produit anti-SHC1 anticorps Détail du antigène SHC1 Information d'application Stockage Haut de la page
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibody (ABIN3043923) Anti- SHC1 Picoband antibody, IHC(P) IHC(P): Mouse Brain Tissue
Immunohistochemistry (IHC) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibody (ABIN3043923) Anti- SHC1 Picoband antibody, IHC(F) IHC(F): Human Placenta Tissue
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibody (ABIN3043923) anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibody (Image 3)
Immunohistochemistry (IHC) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibody (ABIN3043923) Anti- SHC1 Picoband antibody, IHC(P) IHC(P): Rat Brain Tissue
Immunohistochemistry (IHC) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibody (ABIN3043923) Anti- SHC1 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue