anti-Rat (Rattus) TEK anticorps pour Immunohistochemistry (Paraffin-embedded Sections)

Recommended TEK Antibody

Antigène
TEK Tyrosine Kinase, Endothelial (TEK) Anticorps
  • TEK
  • DKFZp469E064
  • AA517024
  • Cd202b
  • Hyk
  • Tie2
  • tie-2
  • CD202B
  • TIE-2
  • TIE2
  • VMCM
  • VMCM1
  • Tie-2
  • tie2
  • TEK receptor tyrosine kinase
  • angiopoietin-1 receptor
  • TEK tyrosine kinase, endothelial
  • TEK
  • LOC100408334
  • tek
  • Tek
Épitope
AA 450-500
29
25
22
20
16
14
11
10
10
8
8
8
6
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
288
163
100
9
8
Hôte
Lapin
236
64
10
3
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp TEK est non-conjugé
21
14
10
8
8
8
8
8
8
7
6
4
4
4
4
4
4
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
173
128
69
52
48
21
21
19
16
12
8
6
6
3
Options

Images

N° du produit ABIN674649
$ 329.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
1 ABIN6719289 IHC (p) WB Rabbit IgG Polyclonal 0
1 ABIN1711776 IHC (p) WB HRP Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1711775 IHC (p) WB HRP Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN674658 IHC (p) WB HRP Rabbit IgG AA 450-500 Polyclonal 0
1 ABIN1700758 IHC (p) WB Biotin Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1700759 IHC (p) WB Biotin Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN746507 IHC (p) WB HRP Rabbit IgG pTyr992 Polyclonal 0
1 ABIN674651 IHC (p) WB Biotin Rabbit IgG AA 450-500 Polyclonal 0
1 ABIN1714260 IF (p) IHC (p) WB Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1714261 IF (p) IHC (p) WB Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN746500 IHC (p) WB Biotin Rabbit IgG pTyr992 Polyclonal 0
1 ABIN746483 IF (p) IHC (p) WB Rabbit IgG pSer1119 Polyclonal 0
1 ABIN746498 IF (p) IHC (p) WB Rabbit IgG pTyr992 Polyclonal 0

General

Antigène TEK Tyrosine Kinase, Endothelial (TEK) Anticorps
Épitope AA 450-500
(29), (25), (22), (20), (16), (14), (11), (10), (10), (8), (8), (8), (6), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(288), (163), (100), (9), (8)
Hôte Lapin
(236), (64), (10), (3), (2), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp TEK est non-conjugé
(21), (14), (10), (8), (8), (8), (8), (8), (8), (7), (6), (4), (4), (4), (4), (4), (4), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(173), (128), (69), (52), (48), (21), (21), (19), (16), (12), (8), (6), (6), (3)
Pubmed 4 références disponible
Fournisseur

Détail du produit anti-TEK anticorps

Détail du antigène TEK Information d'application Stockage References for anti-TEK antibody (ABIN674649) Images
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic peptide derived from human Tie2
Isotype IgG
Plasmids, Primers & others

Détail du antigène TEK

Détail du produit anti-TEK anticorps Information d'application Stockage References for anti-TEK antibody (ABIN674649) Images Haut de la page
Antigène
Autre désignation Tie2/Cd202b (TEK Antibody Extrait)
Sujet

Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.

Subcellular location: Extracellular

Synonyms: TIE2, VMCM, TIE-2, VMCM1, CD22B, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p14 TEK, TEK

ID gène 7010
UniProt Q02763
Pathways Signalisation RTK, Growth Factor Binding

Information d'application

Détail du produit anti-TEK anticorps Détail du antigène TEK Stockage References for anti-TEK antibody (ABIN674649) Images Haut de la page
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Stockage

Détail du produit anti-TEK anticorps Détail du antigène TEK Information d'application References for anti-TEK antibody (ABIN674649) Images Haut de la page
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

References for anti-TEK antibody (ABIN674649)

Détail du produit anti-TEK anticorps Détail du antigène TEK Information d'application Stockage Images Haut de la page
Produit citée dans:

Li, Liu, Liu, Wang, Zhang, Chen, Hui: "Expression of angiopoietins in central nervous system hemangioblastomas is associated with cyst formation." dans: Neuroscience letters, Vol. 639, pp. 120-125, 2017 Méthode utilisée: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Échantillon (espèces): Human). Détails: Sample: tumor

Xiang, Hu, Shen, Liu, Hua, Zan, Zu, Cui, Ye: "Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats." dans: Neuroscience letters, Vol. 644, pp. 62-66, 2017 Méthode utilisée: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Échantillon (espèces): Rat (Rattus)). Détails: Sample: brain

Tekari, Chan, Sakai, Grad, Gantenbein: "Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells." dans: Stem cell research & therapy, Vol. 7, Issue 1, pp. 75, 2016 Méthode utilisée: Flow Cytometry (FACS) (Échantillon (espèces): Cow (Bovine)).

Zhao, Hu, Xiang, Gu, Jin, Hua, Zhang, Liu, Zan, Zhang, Zu, Yang, Shi, Zhu, Xu, Cui, Ye: "Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke." dans: Brain research, 2015 Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Rat (Rattus)). Détails: Sample: Brain

Images

Détail du produit anti-TEK anticorps Détail du antigène TEK Information d'application Stockage References for anti-TEK antibody (ABIN674649) Haut de la page
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 450-500) antibody (ABIN674649) Formalin-fixed and paraffin embedded rat retina tissue labeled with Anti TIE2/CD202b ...