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anti-Human VEGFC Anticorps:
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Human Polyclonal VEGFC Primary Antibody pour IHC (fro), IHC (p) - ABIN258871
Zampell, Yan, Avraham, Daluvoy, Weitman, Mehrara: HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
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Human Polyclonal VEGFC Primary Antibody pour IF (p), IHC (p) - ABIN731723
Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2012
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Human Monoclonal VEGFC Primary Antibody pour ICC, IHC (fro) - ABIN438679
Moussai, Mitsui, Pettersen, Pierson, Shah, Suárez-Fariñas, Cardinale, Bluth, Krueger, Carucci: The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C. dans The Journal of investigative dermatology 2010
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Human Polyclonal VEGFC Primary Antibody pour FACS, IHC (p) - ABIN650694
Yan, Zhu, Yu, Ji, Zhang, Ji, Yan, Chen, Liu, Yin, Lin: Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis. dans World journal of gastroenterology : WJG 2004
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Rat (Rattus) Polyclonal VEGFC Primary Antibody pour IP, ELISA - ABIN1589911
Maertens, Erpicum, Detry, Blacher, Lenoir, Carnet, Péqueux, Cataldo, Lecomte, Paupert, Noel: Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis. dans PLoS ONE 2014
Vegfc acts through ERK (Montrer MAPK1 Anticorps) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (Montrer MT2 Anticorps) in angiogenesis, but also propose Mt2 (Montrer MT2 Anticorps) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (Montrer MAFB Anticorps) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (Montrer CCBE1 Anticorps), and Vegfc-driven sprouting is enhanced by local Ccbe1 (Montrer CCBE1 Anticorps) overexpression. Moreover, Vegfc- and Vegfr3 (Montrer FLT4 Anticorps)-dependent Erk (Montrer MAPK1 Anticorps) signaling is impaired in the absence of Ccbe1 (Montrer CCBE1 Anticorps).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (Montrer FLT4 Anticorps) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.
VEGF-C and VEGF-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (Montrer RLN1 Anticorps) and recombinant human relaxin-2 (Montrer RLN1 Anticorps) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
High expression of VEGF-C in the primary tumour may be a good determinant for detection of occult tumour cells in the lymph nodes of OSCC cases.
document for the first time that CCL5 (Montrer CCL5 Anticorps) induces tumor lymphangiogenesis by the induction of VEGF-C in human cancer cells.
Data suggest that the BRG1 (Montrer SMARCA4 Anticorps)/STAT3 (Montrer STAT3 Anticorps)/VEGFC in tumor-associated lymphangiogenesis might lead to the discovery of novel therapeutic targets in the treatment of cancers with BRG1 (Montrer SMARCA4 Anticorps) loss of function.
Studied the effect of recombinant human vascular endothelial growth factor (VEGF)-C on lymphangiogenesis, inflammation, and fibrosis in the mouse kidney using the unilateral ureteral obstruction (UUO); lymphangiogenesis was significantly induced in the UUO+VEGF-C group. In lymphatic endothelial cells, VEGF-C increased the activity and proliferation of such cells and expression of VCAM-1.
In multivariate analysis, only serum VEGF-A (Montrer VEGFA Anticorps) correlated to diabetes duration, whereas VEGF-C only correlated to HbA1c and fasting blood glucose.
This study reports that human dendritic cells produce VEGF-C, a cytokine with potent pro-lymphangiogenic activity when stimulated with IFN-gamma (Montrer IFNG Anticorps)
Association of coexpressed high levels of VEGF-C and active MMP-9 (Montrer MMP9 Anticorps) with lymphatic spreading and local invasiveness of Papillary thyroid carcinoma (PTC (Montrer F9 Anticorps)) suggests their potential usefulness as predictive biomarkers of aggressive PTC (Montrer F9 Anticorps) behavior.
Data show that VEGF-C, VEGF-D (Montrer Figf Anticorps), and VEGFR-3 (Montrer FLT4 Anticorps) were expressed in a substantial percentage of breast carcinomas.
By treating LECs with VEGF (Montrer VEGFA Anticorps)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (Montrer JUN Anticorps)' transcription factors that showed a rapid transient upregulation VEGFR-3 (Montrer FLT4 Anticorps) stimulation. these results reveal an important and unanticipated role of HOXD10 (Montrer HOXD10 Anticorps) in the regulation of VEGFR-3 (Montrer FLT4 Anticorps) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (Montrer Adamts2 Anticorps) and CCBE1 (Montrer CCBE1 Anticorps) spatially and temporally patterns developing lymphatics, and one in which VEGFD (Montrer Figf Anticorps) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (Montrer IL6 Anticorps)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (Montrer SRC Anticorps)-FAK (Montrer PTK2 Anticorps)-STAT3 (Montrer STAT3 Anticorps) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (Montrer HPSE Anticorps)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (Montrer SDC1 Anticorps)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (Montrer SDC1 Anticorps)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X (Montrer MT1X Anticorps) metallothioneins (MTs (Montrer NEU2 Anticorps)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (Montrer TGFB1 Anticorps) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
MT1-MMP (Montrer MMP14 Anticorps) directly cleaves LYVE-1 (Montrer LYVE1 Anticorps) on lymphatic endothelial cells to inhibit LYVE-1 (Montrer LYVE1 Anticorps)-mediated lymphangiogenic responses and restrains the production of VEGF-C.
HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (Montrer FGF1 Anticorps)-C production from macrophages through Toll-like receptor 4 (Montrer TLR4 Anticorps)-dependent signal pathway
Results showed that the VEGF-C/VEGFR-3 (Montrer FLT4 Anticorps) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184