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Human CD36 Protein expressed in Human Cells - ABIN2003345
Xu, Efremov, Li, Lai, Dao, Lim, Cao: Probing the cytoadherence of malaria infected red blood cells under flow. dans PLoS ONE 2013
We identified CD36 as one of the most significantly upregulated lipid-related genes in senescent cells. We showed that overexpression of CD36 in proliferating cells resulted in a senescence-like phenotype. We hypothesize that CD36 overexpression leads to changes in membrane remodeling and plausibly mediate SASP (Montrer ASPRV1 Protéines) release.
Our findings indicated that hepatic stellate cells-derived COMP (Montrer COMP Protéines) collaborated with CD36 and subsequently played an essential role in MEK (Montrer MAP2K1 Protéines)/ERK (Montrer EPHB2 Protéines) and PI3K (Montrer PIK3CA Protéines)/AKT (Montrer AKT1 Protéines)-mediated hepatocellular carcinoma (HCC (Montrer FAM126A Protéines)) progression. COMP (Montrer COMP Protéines) might act as a promising target for the diagnosis and treatment of aggressive HCC (Montrer FAM126A Protéines).
Study shows the CD36 expression level downregulated in the lung cancer. Further, results found that the high methylation of CD36 corresponding to its low expression in lung cancer played an important role in the procession of lung cancer.
The rs7755 and rs3211956 loci polymorphisms of CD36 gene and genotype E2/E3, E3/E4, E4/E4 of ApoE (Montrer APOE Protéines) gene, and E2 and E4 alleles were statistically related with Alzheimer disease.
This study suggests that T2D patients with different genotypes at CD36, NOS3 and PPARG (Montrer PPARG Protéines) respond differentially to intervention of omega-3 supplements in blood lipid profiles.
Gene expressions of YKL-40 (Montrer CHI3L1 Protéines) and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma (Montrer PPARG Protéines) and YKL-40 (Montrer CHI3L1 Protéines) was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls
genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (Montrer TAS1R2 Protéines) (rs35874116), and TAS2R38 (Montrer TAS2R38 Protéines) (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS]
CD36 is important for muscle glucose metabolism and optimal insulin (Montrer INS Protéines) responsiveness.
Significant up-regulation of PBMCs CAP1 (Montrer PRSS8 Protéines), CD36 mRNA and plasma resistin (Montrer RETN Protéines) found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin (Montrer RETN Protéines) could be able to exert its effects stronger on cells with up-regulated CAP1 (Montrer PRSS8 Protéines) mRNA thus contributing atherosclerosis development.
CD36, also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs (Montrer FAS Protéines), is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 (Montrer SCD Protéines) inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 knockdown breast cancer cells
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (Montrer CD47 Protéines)-dependent manner
Niacin Reduces serum level and adipose mRNA expression of leptin (Montrer LEP Protéines) and up-regulates PPARgamma (Montrer PPARG Protéines) and CD36 mRNA expression in hypercholesterolemic rabbits.
SIRT1 (Montrer SIRT1 Protéines) upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF-kappaB (Montrer NFKB1 Protéines) pathway in mouse Kupffer cells.
Cd36 deficiency led to reduced expression of phagocytosis receptor Mertk (Montrer MERTK Protéines) and nuclear receptor Nr4a1 (Montrer NR4A1 Protéines) in cardiac macrophages, the latter previously shown to be required for phagocyte survival.
CD36 plays an important proinflammatory role in ConA-induced liver injury by promoting hepatic inflammation and mediating the proapoptotic effect of chemokine (Montrer CCL1 Protéines) CXCL10 (Montrer CXCL10 Protéines), and therefore, may be a potential therapeutic target for immune-mediated hepatitis
both paracrine and endocrine effects of adiponectin may contribute to reduced reactive oxygen species generation and apoptosis after MI/R, in a CD36-dependent manner
Overexpressing STAMP2 (Montrer STEAP4 Protéines) attenuates adipose tissue angiogenesis and insulin (Montrer INS Protéines) resistance in diabetic ApoE (Montrer APOE Protéines)(-/-) /LDLR (Montrer LDLR Protéines)(-/-) mouse via a PPARgamma (Montrer PPARG Protéines)/CD36 pathway.
This study demonstrated the CD36 deletion in mice (CD36(-/-) mice) resulted in an attenuated progression of chronic epilepsy compared with wild-type (WT) mice.
TMP upregulated the protein stability of ABCA1 (Montrer ABCA1 Protéines) without affecting ABCG1 (Montrer ABCG1 Protéines). Accordingly, TMP regulated the expression of SR-A (Montrer MSR1 Protéines), CD36, ABCA1 (Montrer ABCA1 Protéines) and ABCG1 (Montrer ABCG1 Protéines) in aortas of ApoE (Montrer APOE Protéines)-/- mice, which resembled the findings observed in macrophages.
atherogenic condition could activate eosinophils and modulate the phenotype of macrophages (from M2 to M1 phenotype), in part, through the CD36 receptor signaling
CD36 plays a role in the perception of specific odour-active volatile compounds in the nasal cavity.
These results suggest that increased expression of hepatic CD36 and SREBP-1 (Montrer SREBF1 Protéines) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
The findings of this study indicated that Cd36 is a candidate lipid sensor involved in the sensory detection of fatty acid in zebrafish.
Zebrafish Cd36 is a microbial-binding molecule.
The putative role for Cd36 in immune responses of fish in the context of other members of the scavenger receptor class B family, is discussed.
CD36 plays a vital role in the LPS (Montrer IRF6 Protéines)-induced activation of downstream signaling cascades and mediates E. coli phagocytosis via TLR4 (Montrer TLR4 Protéines) in pGMECs, which offers a novel treatment strategy for mastitis
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS IV
, PAS-4 protein
, cluster determinant 36
, fatty acid translocase
, glycoprotein IIIb
, leukocyte differentiation antigen CD36
, platelet glycoprotein 4
, platelet glycoprotein IV
, scavenger receptor class B, member 3
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, CD36 antigen
, collagen type I receptor, thrombospondin receptor