-
CREB and YAP form a positive feedback loop that is critical to maintain the stability of phosphorylated CREB and promote neurite outgrowth.
-
exogenous BDNF mitigates neuronal metabolic defects following mechanical injury by promoting the phospho CREB accumulation in mitochondrial inner membrane and matrix, which is regulated by MPTP opening.
-
High CREB1 expression is associated with Neuroblastoma.
-
The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated vascular dementia that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction.
-
Data show that cAMP-response-element binding protein (CREB) is a central molecular node in the circuit responses after stroke that lead to recovery from motor deficits.
-
copper chelators regulate the balance between amyloidogenic and nonamyloidogenic processing of AbetaPP via promoting ADAM10 expression through MT1/2 /CREB-dependent signaling pathways.
-
Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model.
-
Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli.
-
These findings suggest that dendritic region-specific morphological changes in CA1 neurons by constitutive activation of CREB may contribute to improved learning and STM.
-
this study shows that CREB is a critical regulator of dendritic cells during the germinal center response
-
FXR exerts its function in L cells through interacting with CREB, a crucial transcriptional regulator of cAMP-CREB signaling pathway, to inhibit its transcriptional activity. Targeting FXR to rescue GLP-1 secretion may be a promising strategy for type II diabetes.
-
Antioxidative and Anti-Melanogenic Activities of Bamboo Stems (Phyllostachys nigra variety henosis) via PKA/CREB-Mediated MITF Downregulation in B16F10 Melanoma Cells
-
Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model
-
The absence of gut microbiota from birth was shown to be associated with decreased CREB expression, followed by decreases of protein kinase C beta (PRKCB) and AMPA receptors expression, and an increase of phosphorylation CREB (pCREB) expression.
-
Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor in modulating anxiety-related behaviors.
-
Significant CREB activation in almost the whole amygdala and hippocampus was observed after unconditioned stimulus-retrieval, but conditioned stimulus-retrieval only stimulated CREB activation in the lateral amygdala and the CA3 of hippocampus. In addition, propranolol, a beta-adrenergic receptor antagonist, treatment suppressed memory retrieval-induced CREB activation.
-
Curc-mPEG454 reverses HFD-induced hepatic steatosis via the activation of CREB inhibition.
-
Neuron-specific, adult-deletion of CREB1 alters hippocampal structures and causes neuropathological changes resembling aging brain.
-
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
-
the requirement of Creb1 for normal mammalian lung morphogenesis is not dependent upon its expression in lung epithelium or mesenchyme, nor its role in musculoskeletal development.
