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CREB-mediated signaling plays an important role in early stages of cortical neuron differentiation.
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AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the PKA/CREB pathway.
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CREB and YAP form a positive feedback loop that is critical to maintain the stability of phosphorylated CREB and promote neurite outgrowth.
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exogenous BDNF mitigates neuronal metabolic defects following mechanical injury by promoting the phospho CREB accumulation in mitochondrial inner membrane and matrix, which is regulated by MPTP opening.
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High CREB1 expression is associated with Neuroblastoma.
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The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated vascular dementia that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction.
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Data show that cAMP-response-element binding protein (CREB) is a central molecular node in the circuit responses after stroke that lead to recovery from motor deficits.
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copper chelators regulate the balance between amyloidogenic and nonamyloidogenic processing of AbetaPP via promoting ADAM10 expression through MT1/2 /CREB-dependent signaling pathways.
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Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model.
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Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli.
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These findings suggest that dendritic region-specific morphological changes in CA1 neurons by constitutive activation of CREB may contribute to improved learning and STM.
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this study shows that CREB is a critical regulator of dendritic cells during the germinal center response
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FXR exerts its function in L cells through interacting with CREB, a crucial transcriptional regulator of cAMP-CREB signaling pathway, to inhibit its transcriptional activity. Targeting FXR to rescue GLP-1 secretion may be a promising strategy for type II diabetes.
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Antioxidative and Anti-Melanogenic Activities of Bamboo Stems (Phyllostachys nigra variety henosis) via PKA/CREB-Mediated MITF Downregulation in B16F10 Melanoma Cells
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Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model
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The absence of gut microbiota from birth was shown to be associated with decreased CREB expression, followed by decreases of protein kinase C beta (PRKCB) and AMPA receptors expression, and an increase of phosphorylation CREB (pCREB) expression.
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Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor in modulating anxiety-related behaviors.
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Significant CREB activation in almost the whole amygdala and hippocampus was observed after unconditioned stimulus-retrieval, but conditioned stimulus-retrieval only stimulated CREB activation in the lateral amygdala and the CA3 of hippocampus. In addition, propranolol, a beta-adrenergic receptor antagonist, treatment suppressed memory retrieval-induced CREB activation.
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Curc-mPEG454 reverses HFD-induced hepatic steatosis via the activation of CREB inhibition.
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Neuron-specific, adult-deletion of CREB1 alters hippocampal structures and causes neuropathological changes resembling aging brain.
