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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. dans Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1, and ATF3 during gastrulation.
CREB1 promoted progression of ovarian cancer cells.DQ786243 promoted ovarian cancer-cell growth through miR-506-dependent CREB1 regulation.MiR-506 regulated CREB1 expression by targeting to its 3'-UTR.
GM-CSF-induced CREB is a driver of pancreatic cancer in smokers
CREB1-induced FOXD2-AS1 contributed to glioma progression by upregulating AKT1 via competitively binding to miR-185.
we demonstrated that CREB1 is a downstream target of miR-590-3p and UCA1 activates CREB1 expression by sponging to miR-590-3p.
Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 x 10-4; rs6785, P=6.33 x 10-5), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 x 10-5; rs6785, P=2.44 x 10-5) and MDD
The present results suggested that miR101 may serve a role in colon cancer by directly targeting CREB1. Collectively, the present study may contribute to the development of improved diagnosis and prognostics for colon cancer.
This review focus is on ERK1/2 and/or p38 MAPK-dependent CREB activation associated with various diseases to provide insights for basic and clinical researchers.
Shortwave exposure (27 MHz, with an average power density of 10 and 30 mW/cm2) impaired rats' spatial learning and memory and caused a series of dose-dependent pathophysiological changes. Moreover, NMDAR-related CREB pathway suppression might be involved in shortwave-induced structural and functional impairments in the rat hippocampus.
our data suggest that over expression of CREB may contribute to progression of glioma and knockdown of CREB expression may serve as a novel target for therapy
Data report crystal structures of a complex containing the CRTC2 CREB binding domain, the CREB basic leucine zipper domain and a CRE-containing DNA. CRTC and CREB form a 2:2 complex on CRE-containing DNA, and CRTC interacts with both CREB and DNA through highly conserved residues. Structural studies revealed that both interactions are crucial for the complex assembly and CREB stabilization on DNA.
Studied role of cAMP responsive element binding protein 1 (CREB) in regulation of cullin 4A (CUL4A) transcription thru binding of CUL4A promoter.
CREB role in the Th1/Th2 cell mediated immune responses in leprosy.
CREB1 may not play major role in the pathophysiology of Alzheimer's disease in Han Chinese.
Our results provide evidence that SETD2 and CREB1 contribute to cisplatin cytotoxicity in non-small cell lung cancer via regulation of the ERK signaling pathway, and their inactivation may lead to cisplatin resistance
High CREB1 expression is associated with Neuroblastoma.
This study demonstrates that the presence of rs928413(G) allele in the IL33 promoter results in its increased activity in a human lung carcinoma cell line due to binding of the cAMP (cyclic adenosine monophosphate) response element binding protein 1 (CREB1) transcription factor. The results offer a tentative explanation for the negative effect of rs928413 on asthma development.
findings illustrate the significance of CREB-KDM4B-STAT3 signaling cascade in DNA damage response, and highlight that KDM4B may potentially be a novel oncotarget for colorectal cancer radiotherapy.
CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells.
ethanol-induced eIF2alpha phosphorylation stimulates COX-2 expression and PGE2 production which induces the BACE1 expression and Abeta production via EP-2 receptor-dependent PKA/CREB pathway.
Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli.
The cAMP/Creb axis as a potentially actionable therapeutic vulnerability in p53-deficient tumors such as OS.
Study in a phosphorylation-competent p300 (G442S) knock-in mouse model that ectopically expresses p300 phosphorylation in a homologous site to CREB binding protein Ser436 suggest that a single phosphorylation change in p300 has the capability to modulate hippocampal neurogenesis, Creb binding, and associative fear memory.
iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.
Microglial CREB phosphorylation induced by amyloid beta-protein (1-42,) induces transient memory deficits.
In model of vascular injury lncRNA-SRA promoted vascular smooth muscle cell proliferation by activating the MEK-ERK-CREB pathway.
Specific Alternative cleavage and polyadenylation (APA) regulatory events can impact expression of two molecules with known functions during Hippocampal Long-Term Potentiation, including 3'UTR APA of Notch1 and intronic APA of Creb1.
Selective disruption of CREB function in medial prefrontal cortex (mPFC) engram cells after mild conditioning impairs remote memory expression. Memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.
The Cklfsf2b gene is regulated by GATA-1 and CREB protein, binding to their respective binding elements present in the 2-kb upstream promoter sequence.
CREB-mediated signaling plays an important role in early stages of cortical neuron differentiation.
AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the PKA/CREB pathway.
CREB and YAP form a positive feedback loop that is critical to maintain the stability of phosphorylated CREB and promote neurite outgrowth.
exogenous BDNF mitigates neuronal metabolic defects following mechanical injury by promoting the phospho CREB accumulation in mitochondrial inner membrane and matrix, which is regulated by MPTP opening.
The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated vascular dementia that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction.
Data show that cAMP-response-element binding protein (CREB) is a central molecular node in the circuit responses after stroke that lead to recovery from motor deficits.
copper chelators regulate the balance between amyloidogenic and nonamyloidogenic processing of AbetaPP via promoting ADAM10 expression through MT1/2 /CREB-dependent signaling pathways.
Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model.
These findings suggest that dendritic region-specific morphological changes in CA1 neurons by constitutive activation of CREB may contribute to improved learning and STM.
Data indicate that Ser738/742-to-glutamate protein kinase D mutant increased AngII-induced CREB protein and activating transcription factor 2 phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2
the p38-MAPK/CREB pathway plays a critical role in TNFalpha-induced VCAM-1 expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein