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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. dans Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (Montrer AFT1 Protéines), and ATF3 (Montrer ATF3 Protéines) during gastrulation.
The authors conclude that taurodeoxycholic acid-induced DNA damage may depend on the activation of TGR5 (Montrer GPBAR1 Protéines), CREB and NOX5 (Montrer NOX5 Protéines)-S. It is possible that in Barrett's patients bile acids may activate NOX5 (Montrer NOX5 Protéines)-S and increase reactive oxygen species (ROS (Montrer ROS1 Protéines)) production via activation of TGR5 (Montrer GPBAR1 Protéines) and CREB. NOX5 (Montrer NOX5 Protéines)-S-derived ROS (Montrer ROS1 Protéines) may cause DNA damage, thereby contributing to the progression from Barrett's esophagus to esophageal adenocarcinoma.
The mechanism of CBP (Montrer CREBBP Protéines)-CREB association via their pKID/KIX domains studied by molecular dynamics free energy simulations has been reported.
Results indicate CREB1 as a critical transcription factor of RRM2 (Montrer RRM2 Protéines) which promotes tumor aggressiveness, and imply a significant correlation between CREB1 and RRM2 (Montrer RRM2 Protéines) in CRC (Montrer CALR Protéines) specimens.
Study suggest that both p300 (Montrer EP300 Protéines) and CREB are required for the function integrity of HIF-1alpha (Montrer HIF1A Protéines) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300 (Montrer EP300 Protéines), CREB and HIF-1alpha (Montrer HIF1A Protéines).
These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer
YAP (Montrer YAP1 Protéines)/ TAZ (Montrer TAZ Protéines) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (Montrer CCNE1 Protéines) and CREB
Data demonstrate that CREB is downregulated in glioma cells and is a direct target of miR (Montrer MLXIP Protéines)-433-3p. These findings indicate that CREB subsequently directly or indirectly modulates its target genes to control the cell growth and metastasis in glioma.
these studies demonstrate that transcription factors CREB and c-Myc (Montrer MYC Protéines) maintain the transcriptional activity of STING
GRK3 (Montrer ADRBK2 Protéines) is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells.
miR (Montrer MLXIP Protéines)-150 is a novel Wnt (Montrer WNT2 Protéines) effector that may significantly enhance epithelial-mesenchymal transition of colorectal cancer cells by targeting the CREB signaling pathway
Significant CREB activation in almost the whole amygdala and hippocampus was observed after unconditioned stimulus-retrieval, but conditioned stimulus-retrieval only stimulated CREB activation in the lateral amygdala and the CA3 (Montrer CA3 Protéines) of hippocampus. In addition, propranolol, a beta (Montrer SUCLA2 Protéines)-adrenergic receptor antagonist, treatment suppressed memory retrieval-induced CREB activation.
Curc-mPEG454 reverses HFD-induced hepatic steatosis via the activation of CREB inhibition.
Neuron-specific, adult-deletion of CREB1 alters hippocampal structures and causes neuropathological changes resembling aging brain.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
the requirement of Creb1 for normal mammalian lung morphogenesis is not dependent upon its expression in lung epithelium or mesenchyme, nor its role in musculoskeletal development.
data provide persuasive evidence towards the distinct roles of CREB within the dorsal and ventral hippocampus separately in mediating select nicotine withdrawal phenotypes.
phosphorylation of CREB is downregulated in the Muller glia.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB signaling.
Both CREB and deltaFosB play a role in the induction of this behavioural sensitization.
astrocytic IL-17A (Montrer IL17A Protéines) plays important roles in the maintenance of neuropathic pain through CaMKII (Montrer CAMK2G Protéines)/CREB signaling pathway in spinal cord.
Data indicate that Ser738/742-to-glutamate (Montrer GRIN2A Protéines) protein kinase D (Montrer PRKD1 Protéines) mutant increased AngII-induced CREB protein and activating transcription factor 2 (Montrer ATF2 Protéines) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (Montrer STAR Protéines) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (Montrer LYPLA1 Protéines)
the p38-MAPK (Montrer MAPK14 Protéines)/CREB pathway plays a critical role in TNFalpha (Montrer TNF Protéines)-induced VCAM-1 (Montrer VCAM1 Protéines) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (Montrer MAPK14 Protéines) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (Montrer MAPK14 Protéines) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein