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Human Monoclonal IKBKE Primary Antibody pour ELISA, WB - ABIN969213
Boehm, Zhao, Yao, Kim, Firestein, Dunn, Sjostrom, Garraway, Weremowicz, Richardson, Greulich, Stewart, Mulvey, Shen, Ambrogio, Hirozane-Kishikawa, Hill, Vidal, Meyerson, Grenier, Hinkle, Root et al.: Integrative genomic approaches identify IKBKE as a breast cancer oncogene. ... dans Cell 2007
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Human Polyclonal IKBKE Primary Antibody pour ELISA, WB - ABIN4224388
Rajsbaum, Versteeg, Schmid, Maestre, Belicha-Villanueva, Martínez-Romero, Patel, Morrison, Pisanelli, Miorin, Laurent-Rolle, Moulton, Stein, Fernandez-Sesma, tenOever, García-Sastre: Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. dans Immunity 2014
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Human Monoclonal IKBKE Primary Antibody pour ELISA, WB - ABIN966381
Luttjeboer, Harada, Hughes, Johnson, Lilford, Mol: Tubal flushing for subfertility. dans Cochrane database of systematic reviews (Online) 2007
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Human Polyclonal IKBKE Primary Antibody pour ELISA, IHC - ABIN4324306
Péant, Diallo, Lessard, Delvoye, Le Page, Saad, Mes-Masson: Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. dans Molecular cancer research : MCR 2007
Human Polyclonal IKBKE Primary Antibody pour ICC, IF - ABIN4324307
Sun, Sammut, Wang, Kurihara, Windle, Roodman, Galson: TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013
Studied association between nuclear factor kappa beta1/IKK epsilon (NF-kappaB1 (Montrer NFKB1 Anticorps)/IKKepsilon) gene expression and clinical activity in rheumatoid arthritis (RA). Found there were significant differences in NF-kappaB1 (Montrer NFKB1 Anticorps) and IKKepsilon gene expression (P = .001 and P = .029, respectively) between RA patients with clinical activity and clinical remission.
IKBKE plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.
Inverse association between IKKepsilon and lymph node metastasis in breast cancer.
YPEL5 silencing enhanced the induction of IFNB1 (Montrer IFNB1 Anticorps) by pattern recognition receptors and phosphorylation of TBK1 (Montrer TBK1 Anticorps)/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
results demonstrate that Sphingosine 1-phosphate lyase (SPL (Montrer SGPL1 Anticorps)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (Montrer SGPL1 Anticorps), which provides a mechanistic understanding of the pro-IFN activity of SPL (Montrer SGPL1 Anticorps)
Virus-activated kinase IKKepsilon phosphorylated YAP (Montrer YAP1 Anticorps) at Ser403 and thereby triggered degradation of YAP (Montrer YAP1 Anticorps) in lysosomes and, consequently, relief of YAP (Montrer YAP1 Anticorps)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (Montrer YAP1 Anticorps) negatively regulates miR (Montrer MLXIP Anticorps)-let-7b/i by overexpressing and silencing YAP1 (Montrer YAP1 Anticorps) expression. In addition, miR (Montrer MLXIP Anticorps)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (Montrer YAP1 Anticorps) and suppresses the transportation of YAP1 (Montrer YAP1 Anticorps) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (Montrer YAP1 Anticorps) upward arrow-->miR (Montrer MLXIP Anticorps)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1 (Montrer TBK1 Anticorps)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
IKKepsilon promotes NFATc1 (Montrer NFATC1 Anticorps) phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B (Montrer PDE3B Anticorps), IKKepsilon and TBK1 (Montrer TBK1 Anticorps) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (Montrer APPL1 Anticorps) in TLR3 (Montrer TLR3 Anticorps)/4-dependent TBK1 (Montrer TBK1 Anticorps) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (Montrer ARNTL Anticorps) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (Montrer MLXIP Anticorps)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (Montrer NFKB1 Anticorps) pathway by abolishing IKK-beta (Montrer IKBKB Anticorps) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase