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TAB3 Antigen Profile
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Alternative names and synonyms associated with TAB3
TGF-beta activated kinase 1 and MAP3K7 binding protein 3 (TAB3) ELISA Kit
TGF-beta activated kinase 1/MAP3K7 binding protein 3 (Tab3) ELISA Kit
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (LOC790559) ELISA Kit
MAP3K7IP3 ELISA Kit
NAP1 ELISA Kit
4921526G09Rik ELISA Kit
Map3k7ip3 ELISA Kit
mKIAA4135 ELISA Kit
Protein level used designations for TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3-like
, NF-kappa-B-activating protein 1
, NFkB activating protein 1
, TAK1-binding protein 3
, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
, TGF-beta-activated kinase 1-binding protein 3
, mitogen-activated protein kinase kinase kinase 7 interacting protein 3
, mitogen activated protein kinase kinase kinase 7 interacting protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3