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anti-Human TICAM1 Anticorps:
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Human Polyclonal TICAM1 Primary Antibody pour ICC, IF - ABIN266066
Hoebe, Du, Georgel, Janssen, Tabeta, Kim, Goode, Lin, Mann, Mudd, Crozat, Sovath, Han, Beutler: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. dans Nature 2003
Show all 26 Pubmed References
Human Polyclonal TICAM1 Primary Antibody pour WB - ABIN1881885
Bin, Xu, Shu: TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. dans The Journal of biological chemistry 2003
Show all 5 Pubmed References
Human Polyclonal TICAM1 Primary Antibody pour IP, WB - ABIN1169062
Carty, Goodbody, Schröder, Stack, Moynagh, Bowie: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. dans Nature immunology 2006
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Human Polyclonal TICAM1 Primary Antibody pour ELISA, ICC - ABIN4362350
Shi, Kehrl: MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. dans The Journal of biological chemistry 2008
Human Polyclonal TICAM1 Primary Antibody pour ELISA, WB - ABIN4362353
Bowen, Minns, Johnson, Mitchell, Hutton, Evans: Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. dans Science signaling 2012
Data suggest that endosomal localization of TICAM2 (Montrer TICAM2 Anticorps) is essential for TLR4 (Montrer TLR4 Anticorps)-mediated type I interferon (Montrer IFNA Anticorps)-inducing signaling from endosomes; TICAM2 (Montrer TICAM2 Anticorps) acts as scaffold protein (Montrer HOMER1 Anticorps) and activates TICAM1; N-terminal myristoylation allows TICAM2 (Montrer TICAM2 Anticorps) to anchor to endosomal membrane. (TICAM2 (Montrer TICAM2 Anticorps) = toll like receptor adaptor molecule-2 (Montrer TICAM2 Anticorps); TICAM1 = toll like receptor adaptor molecule-1; TLR4 (Montrer TLR4 Anticorps) = toll-like receptor 4 (Montrer TLR4 Anticorps)) [REVIEW]
Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (Montrer IFNB1 Anticorps) (TRIF (Montrer TRIM69 Anticorps)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (Montrer TRIM69 Anticorps)/RIPK1 (Montrer RIPK1 Anticorps)/caspase-8 (Montrer CASP8 Anticorps) occurs in fibrillary platforms.
Therefore, Seneca Valley virus suppressed antiviral interferon (Montrer IFNA Anticorps) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (Montrer MAVS Anticorps), TRIF (Montrer TRIM69 Anticorps), and TANK by its 3C protease.
TRIF (Montrer TRIM69 Anticorps) gene may contribute to susceptibility of T2DM.
The NF-kappaB (Montrer NFKB1 Anticorps) activated by dsRNA appears not to be the canonical p65 (Montrer GORASP1 Anticorps)/p50 (Montrer CD40 Anticorps) heterodimers.
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (Montrer FOXE1 Anticorps)/HEMGN (Montrer HEMGN Anticorps), SERPINA5 (Montrer SERPINA5 Anticorps) (rs2069974), FTO (Montrer FTO Anticorps) (rs8047395), EVPL (Montrer EVPL Anticorps) (rs2071194), TICAM1 (rs8120) and SCARB1 (Montrer SCARB1 Anticorps) (rs11057820) genes. We found associations with SNPs in FOXE1 (Montrer FOXE1 Anticorps), SERPINA5 (Montrer SERPINA5 Anticorps), FTO (Montrer FTO Anticorps), TICAM1 and HSPA6 (Montrer HSPA6 Anticorps) and and follicular thyroid cancer
IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF (Montrer TRIM69 Anticorps).
TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT (Montrer CHPT1 Anticorps)-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line
involved in signaling that moderates the expression of heme oxygenase1 and il-8 (Montrer IL8 Anticorps) after keratinocytes exposure to dinitrochlorobenzene
Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (Montrer DEFB103A Anticorps) suppresses the polyI:C-induced TLR3 (Montrer TLR3 Anticorps) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (Montrer IFIH1 Anticorps)) and MAVS (IPS1/CARDIF (Montrer MAVS Anticorps)).
Versican (Montrer Vcan Anticorps) is produced by Trif (Montrer RNF138 Anticorps)- and type I interferon (Montrer IFNA Anticorps)-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs
TRIF (Montrer RNF138 Anticorps) contributes to murine host defense during the initial response to leptospiral infection
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (Montrer TRAF1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps)-regulated apoptosis and the p53 (Montrer TP53 Anticorps)/PCNA (Montrer PCNA Anticorps)- and ATM (Montrer ATM Anticorps)/ATR (Montrer ATR Anticorps)-Chk1 (Montrer CHEK1 Anticorps)/2-controlled DNA-damage response pathways.
Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (Montrer NCAM1 Anticorps) expression are regulated by both the MyD88 (Montrer MYD88 Anticorps)- and TRIF (Montrer RNF138 Anticorps)-dependent pathways.
TRIF (Montrer RNF138 Anticorps) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (Montrer FOSL1 Anticorps) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (Montrer TRAF3 Anticorps)), TIR domain-containing adapter inducing IFN-beta (Montrer IFNB1 Anticorps) (TRIF (Montrer RNF138 Anticorps)), and Tank-binding kinase 1 (TBK1 (Montrer TBK1 Anticorps)) via impairing K63-linked polyubiquitination of TRAF3 (Montrer TRAF3 Anticorps) and TRIF (Montrer RNF138 Anticorps).
These results suggested the importance of TRIF (Montrer RNF138 Anticorps) in TLR2 mediated foam cell formation via inflammatory mediators, including MCP-1 (Montrer CPT1B Anticorps).
DENV replication and IFNalpha/beta, TNF-alpha (Montrer TNF Anticorps), IL-12 (Montrer IL12A Anticorps) and IL-18 (Montrer IL18 Anticorps) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (Montrer RNF138 Anticorps), MYD88 (Montrer MYD88 Anticorps) or NF-kB inhibition
The authors demonstrate that, in addition to MyD88 (Montrer MYD88 Anticorps), Yersinia pseudotuberculosis inhibits TRIF (Montrer RNF138 Anticorps) signaling through the type III secretion system effector YopJ.
Results show that toll (Montrer TLR4 Anticorps)/IL-1 (Montrer IL1A Anticorps) domain-containing adaptor inducing IFN-beta (Montrer IFNB1 Anticorps) (TRIF (Montrer RNF138 Anticorps)) is essential for Toll (Montrer TLR4 Anticorps)-like receptors TLR3 (Montrer TLR3 Anticorps)- and TLR4 (Montrer TLR4 Anticorps)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
Inhibition of the Toll (Montrer TLR4 Anticorps)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (Montrer IFNB1 Anticorps) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.
3D-models of rohu TLR3 (Montrer TLR3 Anticorps)-TIR and zebrafish TRIF
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (Montrer NFKB1 Anticorps) and zebrafish type I IFN was described.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (Montrer NFKB1 Anticorps) response promoter
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
TIR domain-containing adapter molecule 1
, TIR domain containing adaptor inducing interferon-beta
, toll-interleukin I receptor domain containing adaptor molecule 1
, toll-like receptor adaptor molecule 1
, TIR domain-containing adapter molecule 1-like
, TIR domain-containing adapter protein inducing IFN-beta
, proline-rich, vinculin and TIR domain-containing protein B
, putative NF-kappa-B-activating protein 502H
, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
, TIR domain-containing adaptor inducing interferon-beta
, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
, TIR-domain containing adaptor inducing IFN-beta