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anti-Human IGFBP5 Anticorps:
anti-Mouse (Murine) IGFBP5 Anticorps:
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Data suggest that IGFBP5 nuclear import is mediated by KPNA5 (Montrer KPNA5 Anticorps)/KPNB1 (Montrer KPNB1 Anticorps) complex; nuclear localization sequence of IGFBP5 is critical domain in this nuclear translocation. (IGFBP5 = insulin-like growth factor binding protein-5; KPNA5 (Montrer KPNA5 Anticorps) = karyopherin subunit alpha-5 (Montrer KPNA5 Anticorps); KPNB1 (Montrer KPNB1 Anticorps) = karyopherin subunit beta-1/importin-beta (Montrer KPNB1 Anticorps))
These results suggest that the C-terminus of IGFBP-5 exerts anti-cancer activity by inhibiting angiogenesis via regulation of the Akt (Montrer AKT1 Anticorps)/ERK (Montrer EPHB2 Anticorps) and NF-kB-VEGF (Montrer VEGFA Anticorps)/MMP-9 (Montrer MMP9 Anticorps) signaling pathway.
AMP (Montrer APRT Anticorps)-IBP5 markedly enhanced keratinocyte migration and proliferation. AMP (Montrer APRT Anticorps)-IBP5-induced keratinocyte activation was mediated by Mrg (Montrer FABP7 Anticorps) X1-X4 receptors with MAPK (Montrer MAPK1 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) pathways.
Factor Xa (Montrer F10 Anticorps) induced endothelial cell senescence through IGFBP-5.
Co-ordinated and reciprocal alteration in IGFBP-2 (Montrer IGFBP2 Anticorps) and -5 expression may play a role in the acquisition of endocrine resistance in breast cancer.
The findings suggest that miR (Montrer MLXIP Anticorps)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 (Montrer ADAMTS5 Anticorps) and IGFBP5.
MiR (Montrer MLXIP Anticorps)-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR (Montrer FRAP1 Anticorps)/STAT3 (Montrer STAT3 Anticorps) signaling.
dysregulation of DNMT3A (Montrer DNMT3A Anticorps) and IGFBP5 is relevant to preeclampsia. Thus, we propose that DNMT3A (Montrer DNMT3A Anticorps) and IGFBP5 can serve as potential markers and targets for the clinical diagnosis and therapy of preeclampsia.
IGFBP5 promoter and exon-I methylation did not have any differences between tumor and adjacent tissues so that IGFBP5 methylation did not change IGFBP5 gene regulation in breast cancer.
IGFBP5 promoted osteogenic differentiation potentials of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells via the JNK (Montrer MAPK8 Anticorps) and MEK (Montrer MAP2K1 Anticorps)/Erk (Montrer EPHB2 Anticorps) signalling pathways.
Data demonstrate that dysregulation of miR (Montrer MLXIP Anticorps)-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function.
proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R (Montrer IGF1R Anticorps) inhibitors
Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression
IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5 (Montrer DOK5 Anticorps). IGFBP-5 and DOK5 (Montrer DOK5 Anticorps) are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Igfbp2 (Montrer IGFBP2 Anticorps)-5 are expressed in distinct and complementary patterns during cochlear development.
indicate that Igf1 (Montrer IGF1 Anticorps) was highly expressed in the mesenchyme, Igf2 and Igf1r (Montrer IGF1R Anticorps) were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium.
we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 (Montrer IGFBP2 Anticorps) as candidate modifier genes of lung tumorigenesis.
investigated the effect of IGFBP5 induction on the progression of liver fibrosis caused by chronic cholangiopathy; expression of IGFBP5 in the Abcb4 (Montrer ABCB4 Anticorps)-/- mice reduces inflammation, oxidative stress, ECM (Montrer MMRN1 Anticorps) deposition and hepatocyte proliferation, thereby reducing liver fibrosis
c-Src (Montrer SRC Anticorps) and IL-6 (Montrer IL6 Anticorps) inhibit osteoblast differentiation and integrate IGFBP5 signalling
Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.
The present study revealed SNPs in exon 1 of IGFBP-5 gene (Montrer GPD1 Anticorps) in the Tibet Mini-pig, possibly providing more understanding of the mechanism of miniaturization
IGFBP-5 gene (Montrer GPD1 Anticorps) is associated with the variation in meat quality, especially in pH value together with other QTLs on chromosome 15.
Endogenous IGFBP-5 or transiently expressed IGFBP-5-EGFP is localized in the nuclei of VSMCs. It possesses transcription-regulatory activity that is IGF independent.
IGFBP5, an important component of IGF signaling pathway, contributes greatly to bovine muscle cell development. A mechanism that miR (Montrer MYLIP Anticorps)-143 can regulate the proliferation and differentiation of bovine MSCs through changing expression of IGFBP5 was elucidated by our study.
This study suggested that that higher level IGFBP-5 expression may have functional significance in lactation persistency.
follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 (Montrer IGFBP4 Anticorps) and -5
GH reduces mRNA and protein expression of IGFBP-5 in bovine mammary epithelial cells, but it does not affect the expression of IGFBP-3 (Montrer IGFBP3 Anticorps)
The transgene in the cell clones was examined by polymerase chain reaction to verify that exogenous DNA (pKAP6-1 and IGFBP-5) had integrated stably into GFb cells
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
, IGF-binding protein 5
, insulin-like growth factor-binding protein 5
, insulin-like growth factor binding protein-5
, insulin-like growth factor binding protein 5
, insulin-like growth factor binding protein 5a
, insulin-like growth factor binding protein 5b