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Mouse (Murine) Polyclonal KREMEN1 Primary Antibody pour CyTOF, FACS - ABIN4899514
Diarra, Stolina, Polzer, Zwerina, Ominsky, Dwyer, Korb, Smolen, Hoffmann, Scheinecker, van der Heide, Landewe, Lacey, Richards, Schett: Dickkopf-1 is a master regulator of joint remodeling. dans Nature medicine 2007
Structure of the dual-mode Wnt (Montrer WNT2 Anticorps) regulator Kremen1 and insight into ternary complex formation with LRP6 (Montrer LRP6 Anticorps) and DKK1 (Montrer DKK1 Anticorps) have been presented.
Ectodermal dysplasia including oligodontia is due to homozygosity for KREMEN1 p.F209S (c.626 T>C).
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 (Montrer DKK1 Anticorps) binding or by cancer mutations.
Six Dkk-1 (Montrer DKK1 Anticorps), three Sost (Montrer SOST Anticorps), one Kremen-1 and 10 LRP-5 (Montrer LRP5 Anticorps) polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction.
The mRNA expression levels of DKK-1 (Montrer DKK1 Anticorps) binding receptor LRP5 (Montrer LRP5 Anticorps)/6 and Krm1/2 in SCs (Montrer TWIST1 Anticorps) from patients with MM were significantly higher than those in myeloma cells and in SCs (Montrer TWIST1 Anticorps) from healthy donors.
This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population.
Kremen may not be essential for Dkk1 (Montrer DKK1 Anticorps)-mediated Wnt (Montrer WNT2 Anticorps) antagonism and Kremen may only play a role when cells express a high level of LRP5 (Montrer LRP5 Anticorps)/6
Functional characterization (Montrer DKK1 Anticorps)of related Kremen proteins i (Montrer WNT2 Anticorps)n mouse.
Kremen1 is expressed in prosensory cells during cochlear developme
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 (Montrer DKK1 Anticorps) binding
Kremen proteins are Dickkopf (Montrer DKK1 Anticorps) receptors that regulate Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signalling
Dkk1 (Montrer DKK1 Anticorps) and Kremen1 play roles in blastocyst activation and uterine receptivity during the window of implantation.
This study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 (Montrer DKK1 Anticorps) as negative regulators of Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling.
Data show that fish lacking Kremen1 protein develop more hair cells per neuromast compared to wild type fish.
Kremen1 modulates Wnt (Montrer WNT2 Anticorps) activity by restricting the range of secreted Dkk (Montrer DKK1 Anticorps) proteins during collective cell migration in the posterior lateral line primordium
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
kringle containing transmembrane protein 1
, kringle-containing transmembrane protein 1
, kremen 1
, kremen protein 1-like
, dickkopf receptor
, kremen protein 1
, kringle domain-containing transmembrane protein 1
, kringle-coding gene marking the eye and the nose
, kringle-containing protein marking the eye and the nose