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anti-Mouse (Murine) LEF1 Anticorps:
anti-Rat (Rattus) LEF1 Anticorps:
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Human Polyclonal LEF1 Primary Antibody pour IF (p), IHC (p) - ABIN735248
Song, Man, Wang, Bai, Wei, Liu, Liu, Gu, Wang: The Regenerating Spinal Cord of Gecko Maintains Unaltered Expression of ?-Catenin Following Tail Amputation. dans Journal of molecular neuroscience : MN 2014
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Human Monoclonal LEF1 Primary Antibody pour RNAi, ELISA - ABIN565556
Hebenstreit, Giaisi, Treiber, Zhang, Mi, Horejs-Hoeck, Andersen, Krammer, Duschl, Li-Weber: LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. dans The Journal of biological chemistry 2008
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Human Polyclonal LEF1 Primary Antibody pour ELISA, WB - ABIN188546
Yasumoto, Takeda, Saito, Watanabe, Takahashi, Shibahara: Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling. dans The EMBO journal 2002
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Dog (Canine) Polyclonal LEF1 Primary Antibody pour ELISA, WB - ABIN547651
Radtke, Clevers: Self-renewal and cancer of the gut: two sides of a coin. dans Science (New York, N.Y.) 2005
Human Polyclonal LEF1 Primary Antibody pour IF (p), IHC (p) - ABIN1387756
Fu, Huang, Wang, Chen, Huang, Lu, Liang, Zhang: Proteome Profile and Quantitative Proteomic Analysis of Buffalo (Bubalusbubalis) Follicular Fluid during Follicle Development. dans International journal of molecular sciences 2016
Human Polyclonal LEF1 Primary Antibody pour ICC, IF - ABIN4330626
Asplund, Gry Björklund, Sundquist, Strömberg, Edlund, Ostman, Nilsson, Pontén, Lundeberg: Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma. dans The British journal of dermatology 2008
Data suggest that LEF1-dependent genes in zebrafish hypothalamus are associated with anxiety; LEF1 null mutant zebrafish exhibit increased anxiety.
mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 expression) in zebrafish embryos.
Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt/beta-catenin effector Lef1.
Lef1 has a role in regulating Dusp6 in formation of the zebrafish posterior lateral line primordium
Nlk2 is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.
Data conclude that lef1-mediated Wnt signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.
Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a in regulating lef1.
high-affinity binding sites for Tcf/Lef1 within the boz promoter region
Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis.
Domain-specific regulation of foxP2 CNS expression by lef1.
Skeletal muscle stem cells underwent a switch from beta-catenin-Lef1 to Smad3-Lef1 interactions during the postnatal switch from proliferation to quiescence, with beta-catenin-Lef1 interactions recurring during damage-induced reactivation.
Convergence of the BMP and WNT pathways at the level of the T-cell factor/lymphoid enhancer factor gene Lef1.
High LEF1 expression is associated with Melanoma.
we identified CYGB as an important regulator of osteosarcoma (OS) extravasation and highlighted the importance of the LEF1-CYGB regulatory axis in OS metastasis to the lungs.
Lef1 and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
Data (including data from studies using transgenic/knockout mice) suggest that expression of Lef1 in hypothalamus inhibits anxiety and regulates neurogenesis; expression of Lef1 in hypothalamus is required for neurogenesis.
Uncovering a Pitx2-Sox2-Lef-1 transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.
this study shows that the transcription factors Tcf1 and Lef1 suppress CD4+ T lineage genes in CD8+ T cells through intrinsic histone deacetylase activity
leukemic stem cells are therefore more sensitive to loss of Tcf1 and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.
Sp5/8 bind directly to GC boxes in Wnt target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin to target gene enhancers.
This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of Natural Killer T cells.
this study gives new insights into transcriptional regulating mechanisms of Wnt-mediated Isl1 expression during cardiomyocyte differentiation.
data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.
These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.
TDG, as a new coactivator, promotes beta-catenin/TCFs transactivation and functionally cooperates with CBP in canonical Wnt signaling.
TCF-1 and LEF-1 adopted distinct genetic 'wiring' to promote the CD4(+) T cell fate and establish CD8(+) T cell identity.
Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.
Activation of beta-catenin/TCF signaling by lysophosphatidic acid may be involved in neurogenesis by controlling the survival of neural precursors.
LEF-1 induces epithelial-mesenchymal transition in a b-catenin- independent manner.
data demonstrate that Lef-1 is an important factor for HSC and progenitor function and that its stem cell regulatory role depends on its DNA binding ability
Tcf/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt/beta-catenin signalling and to trigger tissue-specific responses.
Interaction of Xom and LEF1/TCF-factors is essential for ventral cell fate determination and LEF1/TCF factors may function as a point of convergence to mediate the combined signaling of Wnt/beta-catenin and BMP4/Xom pathways during early embryogenesis.
LEF1 could enhance the self-renewal ability.
Comparison of beta-Catenin and LEF1 Immunohistochemical Stains in Desmoid-type Fibromatosis and its Selected Mimickers, With Unexpected Finding of LEF1 Positivity in Scars.
Study revealed that miR300 expression was significantly decreased in hepatocellular carcinoma (HCC) cell lines compared with normal liver cells. LEF1 which was verified as a direct target gene of miR300, promoted cell proliferation, migration and invasion and mediates the effects of miR300. Low expression of miR300 and high expression of LEF1 in HCC tissues is associated with poor prognosis of patients with HCC.
These results provide new insight into the mechanisms underlying hyperactivation of the Wnt/beta-catenin pathway in hepatocellular carcinoma, as well the oncogenic ability of TFAP4 to enhance the tumor-forming ability of hepatocellular carcinoma cells via its binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1).
High LEF1 expression is associated with Drug Resistance in Colorectal Cancer.
The expression of LEF1 associated positively with TCF1 (TCF7) and clinical progression of nasopharyngeal carcinoma, predicting poor prognosis.
Sinonasal glomangiopericytomas (sinonasal-type hemangiopericytomas) with CTNNB1 exon 3 mutation and LEF1 expression in tumor cells.
Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis.
LEF-1 and CDX2 performed at least as well as beta-catenin, if not better, as a diagnostic marker for pilomatrical carcinomas
study identifies a novel mechanism of hepatocellular carcinoma inhibition through beta-catenin-independent Wnt signalling, which is regulated by WT1-associated LEF1 repression. The study also highlights mangiferin as a promising Wnt inhibitor for HCC treatment.
High LEF1 expression is associated with papillary thyroid carcinoma.
LEF1 was consistently expressed in the tubal-peritoneal junctions and all tubal intraepithelial lesions, independent of p53 status.
these data suggest that LEF1 rather has tumor suppressive functions and attenuates aggressiveness in a subset of RMS.
Positive LEF-1 favors a benign neoplasm.
Results show that high enhancer-binding factor-1 (LEF1) expression is associated with poor survival for chronic lymphocytic leukemia (CLL) patients.
Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation
Data indicate that microRNA miR-27a directly targets GSK-3beta and increases expression of beta-catenin and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells.
and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio tRNA modification, are up-regulated in human breast cancers and sustain metastasis.
MicroRNA-557 might work as a tumor suppressor by negatively regulating the expression of lymphocyte enhancement factor 1 in lung cancer cells.
The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
lymphoid enhancer binding factor-1
, lymphoid enhancer-binding factor 1
, lymphoid enhancer-binding factor 1-like
, lymphoid enhancer binding factor 1 short isoform
, T cell-specific transcription factor 1-alpha
, lymphiod enhancer binding factor 1
, transcription factor LEF-1
, lymphoid enhancer binding factor 1