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Study concludes that lethal giant larvae 1 is essential for radial glial cell development and neural migration during cerebral cortex development.
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Study showed that Lgl bound with aPKC and PAR-6B competing against PAR-3A in PAR complex which resulted in pleural mesothelial cell (PMCs) polarity loss, and Lgl1 knockdown maintained the PMC polarity and attenuated pleural fibrosis.
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Data establish Lgl1 as a suppressor of gliomagenesis and positive regulator of asymmetric division and differentiation in the healthy and demyelinated murine brain.
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Ablation of Llgl1 gene Results in Severe Brain Malformation.
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Lgl1 is required for the development of the olfactory bulb.
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results suggest that neural stem cell-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1-dependent global and cell intrinsic mechanisms.
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These results reveal a novel role for Lgl-1 in the regulation of virus-specific T-cell responses and antitumor immunity.
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Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1)-Pax2 protein knockout embryos.
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Lgl1 forms two distinct complexes in vivo, Lgl1-NMIIA and Lgl1-Par6alpha-aPKCzeta, and that the formation of these complexes is affected by the phosphorylation state of Lgl1.
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Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.
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Collectively these findings indicate that Lgl1 regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.
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This is the first study to demonstrate the involvement of Dlg1, Scrib, and Lgl1 in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.
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Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
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mgl-1 mRNA is developmentally expressed in CNS, craniofacial region, eyes, limbs, and the gut
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results reveal a critical role for mammalian Lgl1 in regulating of proliferation, differentiation, and tissue organization and demonstrate a potential causative role of disruption of cell polarity in neoplastic transformation of neuroepithelial cells.
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Early branching morphogenesis in the lung and kidney is stimulated by retinoic acid, and retinoic acid response elements in the Lgl1 promoter are identified.