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anti-Mouse (Murine) Phospholipase C beta 1 Anticorps:
anti-Human Phospholipase C beta 1 Anticorps:
anti-Rat (Rattus) Phospholipase C beta 1 Anticorps:
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Data show that phospholipase C (PLC)-beta1 (PLC-beta1) overexpression determines an increase in beta-catenin translocation and that PLC-beta1, inositol polyphosphate multikinase (IPMK) and beta-catenin are mediators of the same signaling pathway.
functions in plasma membrane remodeling, particularly caveolae formation
Plcb1 plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. (Review)
Unpredictable chronic mild stress mice exhibited lower nucleus accumbens (NAC) shell levels of phospholipase Cbeta.
Heightened PLCbeta1b activity observed in diseased myocardium contributes to pathology by PKCalpha-mediated contractile dysfunction.
inhibition of miR-214 in C2C12 cells significantly enhances the protein level of PLCbeta1 and promotes C2C12 BMP-2-induced osteogenesis by targeting PLCbeta1
Results indicate that PLC-beta1 signalling in the medial prefrontal cortex is required for working memory
In pro-B-lymphoblastic cells (Ba/F3), treated with H2O2, PI-PLCbeta1b conferred resistance to cell death, promoting cell cycle progression and cell proliferation and influencing the expression of cyclin A and E.
Tnis study demonistrated that plc beta1 distribuate in mice cerebellum.
Described is the interaction of nuclear PI-PLCbeta1b with a number of proteins involved in nuclear import, differentiation, mRNA processing, and apoptosis, thereby hinting at novel targets for therapeutic intervention in hematological malignancies.
PLCbeta coupling to D1 dopamine receptor regulates forward locomotion.
Defective PLCbeta1-mediated signalling during implantation is associated with the implantation failure, aberrant ovarian steroid signalling and endocannabinoid metabolism.
Galphaq-coupled Lpar1 regulates cell proliferation and migration by activating two distinct PLC-beta isozymes, PLC-beta1 and PLC-beta2, respectively.
These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
Demonstrate critical role of the glutamatergic system in the phenotype of the PLC-beta1 knockout mouse and highlight the role of these interconnected signalling pathways in schizophrenia-like behavioural disruption.
Regulation of nuclear phospholipase C, beta 1 (review)
Expression of Plcb1 was studied in a cell line during myoblast differentiation.
PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons.
phospholipase C, beta 1 signalling pathway plays a role in the development of normal cortical circuitry
nuclear PLCbeta1 up-regulated the expression of CD24. The correlation was strengthened by the observation that when PLCbeta1 expression was silenced by means of small interfering RNA, CD24 expression was down-regulated
rs1047383 in the PLCB1 gene is associated with cocaine dependence. PLCB1 expression is upregulated in the nucleus accumbens of cocaine abusers.
The intronic PLCB1 InDel is the first variant found in familial multiple papilloid adenomata-type multinodular goiter and in a subset of patients with sporadic multinodular goiter.
PLCbeta1 is a candidate signature gene for proneural subtype high-grade glioma.
Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
Phospholipase C beta connects G protein signaling with RNA interference. (Review)
The role of PLCb1 nuclear isoform is being analyzed in relation to the cell cycle regulation, the cell differentiation, and different physiopathological pathways focusing on the importance of the nuclear localization from both molecular and clinical point of view. (Review)
PI-PLCbeta1 is a modulator of hematopoiesis. [review]
Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease.
Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics.
The rs6108160 polymorphism in the PLCB1 gene reached statistical significance after antidepressant drug use.
results show that PI-PLCbeta1 quantification in MDS predicts the response to azacitidine and is associated with an increased myeloid differentiation.
one specific Egr-1 binding site was identified at nt-451/-419 and PLCB1 promoter activity was increased more than 5-fold
Cholesterol regulates HERG K+ channel activation by increasing phospholipase C beta1 expression
Our data indicate that the amplification of PLCb1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis.
PLCB1 is now reported in a number of different EIEE (early infantile epileptic encephalopathy) phenotypes and our report provides further evidence for phenotypic pleiotropy encountered in early infantile epilepsy syndromes.
Phospholipase C-beta1 and beta4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells.
Novel variations in PLCB1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI).
PLC-beta1 and DAGL-alpha are detected in discrete brain regions, with a marked predominance of pyramidal morphologies of positive cortical cells.[review]
nuclear PI-PLCb1 signalling is involved in diseases showing an altered myogenic differentiation and affecting the hematopoietic system.[review]
Interaction between PLCbeta1 and TRAX affect the function of TRAX as part of the machinery involved in RNA interference. [review]
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
phosphoinositide-specific phospholipase C beta 1
, phospholipase C, beta 1 (phosphoinositide-specific)
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1-like
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
, phosphoinositide phospholipase C
, phosphoinositide phospholipase C-beta-1
, phospholipase C-beta-1
, phospholipase C-beta-1a
, monophosphatidylinositol phosphodiesterase
, phosphoinositidase C
, phospholipase C-I
, triphosphoinositide phosphodiesterase
, Phospholipase C-beta1