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anti-Human PKC alpha Anticorps:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody pour ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. dans Neuron 1999
Show all 14 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody pour IF, IP - ABIN967750
Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. dans The Journal of comparative neurology 2008
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Chicken Monoclonal PKC alpha Primary Antibody pour IF, IP - ABIN967751
Nishizuka: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. dans Nature 1988
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Chicken Monoclonal PKC alpha Primary Antibody pour ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. dans The Journal of biological chemistry 2001
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Human Polyclonal PKC alpha Primary Antibody pour WB - ABIN3043549
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. dans Japanese journal of clinical oncology 2015
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Human Polyclonal PKC alpha Primary Antibody pour IHC (p), WB - ABIN3043025
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. dans International immunopharmacology 2015
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Human Polyclonal PKC alpha Primary Antibody pour IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. dans Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Human Monoclonal PKC alpha Primary Antibody pour ICS - ABIN1177145
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. dans The Biochemical journal 2003
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (Montrer CDK2 Anticorps), leading to shortening of G1 and S phases
Neural induction by Syn4 (Montrer SNTG1 Anticorps) through the PKC (Montrer PKC Anticorps) pathway requires inhibition of PKCdelta (Montrer PKCd Anticorps) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (Montrer PKC Anticorps) of the KCNE1 (Montrer KCNE1 Anticorps) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (Montrer PKC Anticorps) in Kv4.3 (Montrer KCND3 Anticorps)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
PRKCA is a recurrently mutated oncogene (Montrer RAB1A Anticorps) in human chordoid glioma.
Our study showed that PKCalpha modulated cell resistance to apoptosis by stimulating NF-kappaB (Montrer NFKB1 Anticorps) activation and thus promoted the tumorigenesis of bladder cancer.
PKCalpha translocation may occur as an early event in radiation-induced bystander responses.
our study indicated that PKC alpha and beta appeared coping with oncogenic Ras or mutated Akt to maintain the balance of the homeostasis in cancer cells. Once these PKC isoforms were suppressed, the redox state in the cancer cells was disrupted, which elicited persistent oncogenic stress and subsequent apoptotic crisis.
high expression of both PLCE1 (Montrer PLCE1 Anticorps) and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
In nasopharyngeal carcinoma, PKCalpha is linked to the invasion of adjacent tissues, especially in the skull base. Down-regulation of PKCalpha is a risk factor for regional lymph node metastasis.
LAV-BPIFB4 (Montrer BPIFB4 Anticorps) isoform modulates eNOS (Montrer NOS3 Anticorps) signalling through Ca2 (Montrer CA2 Anticorps)+/PKC-alpha-dependent mechanism.
Studied interactions between protein kinase C alpha (PKCalpha), FOXC2 (Montrer FOXC2 Anticorps), and p120-catenin (CTNND1 (Montrer CTNND1 Anticorps)) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2 (Montrer FOXC2 Anticorps), which in turn represses the expression of p120-catenin (Montrer CTNND1 Anticorps), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Phosphorylated PKCalpha is elevated in epidermis genetically deleted of DLX3 (Montrer DLX3 Anticorps) and the hyperproliferative response to TPA (Montrer PLAT Anticorps) is increased, suggesting that the homeobox protein indirectly regulates the activity in the pathway, possibly through an effect on reduced phosphatase expression
Results show that PKCalpha expression is under the regulation of miR (Montrer MLXIP Anticorps)-142-3p contributing to reduced osteoclasts survival.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC (Montrer PLC Anticorps)) and protein kinase C (PKC (Montrer PKC Anticorps)).
However, the mechanism that induces release of IL-6 (Montrer IL6 Anticorps) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (Montrer IL6 Anticorps) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC (Montrer PKC Anticorps), and cAMP response element-binding protein signal transduction pathway.
protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 (Montrer MAPK7 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) is activated in response to PDGF (Montrer PDGFA Anticorps)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (Montrer MAP3K2 Anticorps), Mek1 (Montrer MAP2K1 Anticorps)/2, Mek5 (Montrer MAP2K5 Anticorps), PI3-kinase (Montrer PIK3CA Anticorps) and protein kinase C (PKC (Montrer PKC Anticorps)).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (Montrer SYT1 Anticorps) phosphorylation is an essential step in PKC (Montrer PKC Anticorps)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (Montrer PKC Anticorps) substrates, Munc13-1 (Montrer UNC13A Anticorps) and Munc18-1 (Montrer STXBP1 Anticorps).
These data indicate that LPA increases CCN2 (Montrer CTGF Anticorps) expression through the activation of PKC (Montrer PKC Anticorps) and PKA. Thus, the regulatory functions of the PKC (Montrer PKC Anticorps) and PKA pathways are implicated in the LPA-induced increase in CCN2 (Montrer CTGF Anticorps) expression
PKC (Montrer PKC Anticorps) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (Montrer GRM5 Anticorps) and AMPA (Montrer GRIA3 Anticorps)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (Montrer CA2 Anticorps)+-sensitivity, structure and kinetics are brought about through PKC (Montrer PKC Anticorps) phosphorylation of cardiac troponin T (Montrer TNNT2 Anticorps).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (Montrer TIMP2 Anticorps) expression by NF-kappaB (Montrer NFKB1 Anticorps)-MT1-MMP (Montrer MMP14 Anticorps)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (Montrer ASS1 Anticorps) Ser (Montrer SIGLEC1 Anticorps)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (Montrer TUBB Anticorps).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (Montrer Akap6 Anticorps)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps)
By regulating VEGFR2 (Montrer KDR Anticorps) expression and activation, PKC-epsilon (Montrer PRKCE Anticorps) expression is critical for activation of Akt (Montrer AKT1 Anticorps) and eNOS (Montrer NOS3 Anticorps) by VEGF (Montrer VEGFA Anticorps) and contributes to VEGF (Montrer VEGFA Anticorps)-stimulated Erk (Montrer MAPK1 Anticorps) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (Montrer CA2 Anticorps)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (Montrer PPP1R14A Anticorps) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (Montrer ESR1 Anticorps).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha