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anti-Human PKC alpha Anticorps:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody pour ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. dans Neuron 1999
Show all 14 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody pour ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. dans The Journal of biological chemistry 2001
Show all 4 Pubmed References
Human Polyclonal PKC alpha Primary Antibody pour WB - ABIN3043549
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. dans Japanese journal of clinical oncology 2015
Show all 2 Pubmed References
Human Polyclonal PKC alpha Primary Antibody pour IHC (p), WB - ABIN3043025
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. dans International immunopharmacology 2015
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Human Polyclonal PKC alpha Primary Antibody pour IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. dans Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Mammalian Monoclonal PKC alpha Primary Antibody pour IHC (fro), WB - ABIN2476256
Donovan, Lansu, Williams, Denning, Gentile: Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase C? consensus site. dans Molecular pharmacology 2012
Human Monoclonal PKC alpha Primary Antibody pour ICS - ABIN1177144
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. dans The Biochemical journal 2003
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (Montrer CDK2 Anticorps), leading to shortening of G1 and S phases
Neural induction by Syn4 (Montrer SNTG1 Anticorps) through the PKC (Montrer PKC Anticorps) pathway requires inhibition of PKCdelta (Montrer PKCd Anticorps) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (Montrer PKC Anticorps) of the KCNE1 (Montrer KCNE1 Anticorps) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (Montrer PKC Anticorps) in Kv4.3 (Montrer KCND3 Anticorps)
Data show that PKC (Montrer PKC Anticorps) staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2 (Montrer PCP2 Anticorps).
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure
our results demonstrate that Pc-induced expression of HO-1 (Montrer HMOX1 Anticorps) is mediated by the PKCA-Nrf-2 (Montrer GABPA Anticorps)/HO-1 (Montrer HMOX1 Anticorps) pathway, and inhibits UVB-induced apoptotic cell death in primary skin cells.
Regulation of vascular smooth muscle cell calcification by syndecan-4 (Montrer SDC4 Anticorps)/FGF-2 (Montrer FGF2 Anticorps)/PKCalpha signalling and cross-talk with TGF-beta1 (Montrer TGFB1 Anticorps).
this study reveals a protective role for miR (Montrer MLXIP Anticorps)-706 by blocking the oxidative stress-induced (Montrer SQSTM1 Anticorps) activation of PKCalpha/TAOK1 (Montrer TAOK1 Anticorps). Our results further identify a major implication for miR (Montrer MLXIP Anticorps)-706 in preventing hepatic fibrogenesis and suggest that miR (Montrer MLXIP Anticorps)-706 may be a suitable molecular target for anti-fibrosis therapy.
We also discuss the contribution of PKC (Montrer PRRT2 Anticorps) enzymes to pancreatic diseases, including insulin (Montrer INS Anticorps) resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer
data provided evidence that increased Rack1 (Montrer GNB2L1 Anticorps)-mediated upregulation of PKC (Montrer PRRT2 Anticorps) kinase activity may be responsible for the development of chemoresistance in T-ALL-derived cell line potentially by reducing FEM1b (Montrer FEM1B Anticorps) and Apaf-1 (Montrer APAF1 Anticorps) level.
Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells has been summarized. (Review)
these data propose a mechanism where CD82 (Montrer CD82 Anticorps) membrane organization regulates sustained PKCalpha signaling that results in an aggressive leukemia phenotype. These observations suggest that the CD82 (Montrer CD82 Anticorps) scaffold may be a potential therapeutic target for attenuating aberrant signal transduction in acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)).
MiR (Montrer MLXIP Anticorps)-3148 may play an important role in the development of CTEPH. The key mechanisms for this miRNA may be hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-3148-AR-pathways in cancer or hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-3148-PRKCA-pathways in cancer/glioma/ErbB (Montrer EGFR Anticorps) signaling pathway.
PRKCA is a recurrently mutated oncogene (Montrer RAB1A Anticorps) in human chordoid glioma.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC (Montrer PLC Anticorps)) and protein kinase C (PKC (Montrer PKC Anticorps)).
LAV-BPIFB4 (Montrer BPIFB4 Anticorps) isoform modulates eNOS (Montrer NOS3 Anticorps) signalling through Ca2 (Montrer CA2 Anticorps)+/PKC-alpha-dependent mechanism.
However, the mechanism that induces release of IL-6 (Montrer IL6 Anticorps) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (Montrer IL6 Anticorps) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC (Montrer PKC Anticorps), and cAMP response element-binding protein signal transduction pathway.
protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 (Montrer MAPK7 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) is activated in response to PDGF (Montrer PDGFA Anticorps)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (Montrer MAP3K2 Anticorps), Mek1 (Montrer MAP2K1 Anticorps)/2, Mek5 (Montrer MAP2K5 Anticorps), PI3-kinase (Montrer PIK3CA Anticorps) and protein kinase C (PKC (Montrer PKC Anticorps)).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (Montrer SYT1 Anticorps) phosphorylation is an essential step in PKC (Montrer PKC Anticorps)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (Montrer PKC Anticorps) substrates, Munc13-1 (Montrer UNC13A Anticorps) and Munc18-1 (Montrer STXBP1 Anticorps).
These data indicate that LPA (Montrer LPA Anticorps) increases CCN2 (Montrer CTGF Anticorps) expression through the activation of PKC (Montrer PKC Anticorps) and PKA. Thus, the regulatory functions of the PKC (Montrer PKC Anticorps) and PKA pathways are implicated in the LPA (Montrer LPA Anticorps)-induced increase in CCN2 (Montrer CTGF Anticorps) expression
PKC (Montrer PKC Anticorps) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (Montrer GRM5 Anticorps) and AMPA (Montrer GRIA3 Anticorps)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (Montrer CA2 Anticorps)+-sensitivity, structure and kinetics are brought about through PKC (Montrer PKC Anticorps) phosphorylation of cardiac troponin T (Montrer TNNT2 Anticorps).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (Montrer TIMP2 Anticorps) expression by NF-kappaB (Montrer NFKB1 Anticorps)-MT1-MMP (Montrer MMP14 Anticorps)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (Montrer ASS1 Anticorps) Ser (Montrer SIGLEC1 Anticorps)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (Montrer TUBB Anticorps).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (Montrer Akap6 Anticorps)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps)
By regulating VEGFR2 (Montrer KDR Anticorps) expression and activation, PKC-epsilon (Montrer PRKCE Anticorps) expression is critical for activation of Akt (Montrer AKT1 Anticorps) and eNOS (Montrer NOS3 Anticorps) by VEGF (Montrer VEGFA Anticorps) and contributes to VEGF (Montrer VEGFA Anticorps)-stimulated Erk (Montrer MAPK1 Anticorps) activation, whereas PKC-alpha has opposite effects.
High PKC alpha expression is associated with retinal neovascularization.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (Montrer CA2 Anticorps)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (Montrer PPP1R14A Anticorps) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (Montrer ESR1 Anticorps).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha