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anti-Human PKC alpha Anticorps:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody pour ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. dans Neuron 1999
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Human Polyclonal PKC alpha Primary Antibody pour IHC (p), WB - ABIN3043025
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. dans Japanese journal of clinical oncology 2015
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Human Polyclonal PKC alpha Primary Antibody pour WB - ABIN3043549
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. dans International immunopharmacology 2015
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Chicken Monoclonal PKC alpha Primary Antibody pour ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. dans The Journal of biological chemistry 2001
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Mammalian Monoclonal PKC alpha Primary Antibody pour IHC (fro), WB - ABIN2476256
Donovan, Lansu, Williams, Denning, Gentile: Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase C? consensus site. dans Molecular pharmacology 2012
Human Monoclonal PKC alpha Primary Antibody pour ICS - ABIN1177144
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. dans The Biochemical journal 2003
Human Polyclonal PKC alpha Primary Antibody pour FACS, IF - ABIN391001
Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. dans The Journal of biological chemistry 2011
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (Montrer CDK2 Anticorps), leading to shortening of G1 and S phases
Neural induction by Syn4 (Montrer SNTG1 Anticorps) through the PKC pathway requires inhibition of PKCdelta (Montrer PKCd Anticorps) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 (Montrer KCNE1 Anticorps) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3 (Montrer KCND3 Anticorps)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2 (Montrer PCP2 Anticorps).
Modeling of the different conformations of PRKACA (Montrer PRKACA Anticorps)-DNAJB1 (Montrer DNAJB1 Anticorps) Chimeric Kinase revealed no obvious steric interactions of the J-domain with the rest of the RIIbeta (Montrer PRKAR2B Anticorps) holoenzyme.
PKC activation triggers down-regulation of Kv1.3 by inducing a clathrin-mediated endocytic event that targets the channel to lysosomal-degradative compartments.
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
results could not only better explain the role of PI-PLCbeta1/PKC-alpha signaling in erythropoiesis but also lead to a better comprehension of the lenalidomide effect on del(5q) MDS (Montrer PAFAH1B1 Anticorps) and pave the way to innovative, targeted therapies.
A characteristic di-leucine motif (SVRPLL) in the C-terminal cytoplasmic region of ATP11C becomes functional upon PKCalpha activation. Moreover, endocytosis of ATP11C is induced by Ca(2 (Montrer CA2 Anticorps)+)-signaling via Gq-coupled receptors.
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure
our results demonstrate that Pc-induced expression of HO-1 (Montrer HMOX1 Anticorps) is mediated by the PKCA-Nrf-2 (Montrer GABPA Anticorps)/HO-1 (Montrer HMOX1 Anticorps) pathway, and inhibits UVB-induced apoptotic cell death in primary skin cells.
Regulation of vascular smooth muscle cell calcification by syndecan-4 (Montrer SDC4 Anticorps)/FGF-2 (Montrer FGF2 Anticorps)/PKCalpha signalling and cross-talk with TGF-beta1 (Montrer TGFB1 Anticorps).
this study reveals a protective role for miR (Montrer MLXIP Anticorps)-706 by blocking the oxidative stress-induced (Montrer SQSTM1 Anticorps) activation of PKCalpha/TAOK1 (Montrer TAOK1 Anticorps). Our results further identify a major implication for miR (Montrer MLXIP Anticorps)-706 in preventing hepatic fibrogenesis and suggest that miR (Montrer MLXIP Anticorps)-706 may be a suitable molecular target for anti-fibrosis therapy.
We also discuss the contribution of PKC (Montrer PRRT2 Anticorps) enzymes to pancreatic diseases, including insulin (Montrer INS Anticorps) resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer
Deleting the Prkca gene, which encodes PKCalpha, reverses diabetes-induced autophagy impairment, cellular organelle stress and apoptosis, leading to an NTD reduction. PKCalpha increases the expression of miR-129-2, which is a negative regulator of autophagy. miR-129-2 represses autophagy by directly targeting PGC-1alpha, a positive regulator for mitochondrial function, which is disturbed by maternal diabetes.
This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 (Montrer SLC38A3 Anticorps) transporters in astrocytes in situ.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC).
LAV-BPIFB4 (Montrer BPIFB4 Anticorps) isoform modulates eNOS (Montrer NOS3 Anticorps) signalling through Ca2 (Montrer CA2 Anticorps)+/PKC-alpha-dependent mechanism.
However, the mechanism that induces release of IL-6 (Montrer IL6 Anticorps) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (Montrer IL6 Anticorps) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
PKC activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (Montrer GRM5 Anticorps) and AMPA (Montrer GRIA3 Anticorps)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (Montrer CA2 Anticorps)+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T (Montrer TNNT2 Anticorps).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (Montrer TIMP2 Anticorps) expression by NF-kappaB (Montrer NFKB1 Anticorps)-MT1-MMP (Montrer MMP14 Anticorps)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (Montrer ASS1 Anticorps) Ser (Montrer SIGLEC1 Anticorps)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (Montrer TUBB Anticorps).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (Montrer Akap6 Anticorps)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (Montrer CDK7 Anticorps) Calpha (Montrer PRKACA Anticorps)
By regulating VEGFR2 (Montrer KDR Anticorps) expression and activation, PKC-epsilon (Montrer PRKCE Anticorps) expression is critical for activation of Akt (Montrer AKT1 Anticorps) and eNOS (Montrer NOS3 Anticorps) by VEGF (Montrer VEGFA Anticorps) and contributes to VEGF (Montrer VEGFA Anticorps)-stimulated Erk (Montrer MAPK1 Anticorps) activation, whereas PKC-alpha has opposite effects.
High PKC alpha expression is associated with retinal neovascularization.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (Montrer CA2 Anticorps)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (Montrer PPP1R14A Anticorps) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (Montrer ESR1 Anticorps).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha