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Human TCF7L2 Protein expressed in Wheat germ - ABIN1322376
Shitashige, Satow, Honda, Ono, Hirohashi, Yamada: Regulation of Wnt signaling by the nuclear pore complex. dans Gastroenterology 2008
This work identified Tcf7L2 as the principal transcription factor mediating canonical Wnt (Montrer WNT2 Protéines) signalling in the embryonic neocortex.
TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and primary adipocyte stem cells and th (Montrer INS Protéines)at TCF7L2 expression is required for the regulation of Wnt signaling during adipogenesis.
Data (including data from studies in transgenic mice) suggest that inactivation of Tcf7l2 in pancreatic pericytes is associated with impaired expression of genes required for pancreatic beta-cell function and maturity of isolated pancreatic islets. Transgenic mice in which Tcf7l2 is selectively inactivated in pancreatic pericytes exhibit glucose intolerance.
TCF7L2 does not affect oligodendrocyte precursor cells during remyelination.
the inhibition of beta-catenin's TCF (Montrer HNF4A Protéines)-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells.
Findings demonstrate an alpha cell-autonomous role for Tcf7l2 in the control of pancreatic glucagon (Montrer GCG Protéines) secretion and the maintenance of alpha cell mass and function.
Suggest transcription factor 7-like 2 is a possible regulator of glucagon-like peptide 1 receptor (Montrer GLP1R Protéines) expression in endothelial/smooth muscle cells in diabetic mice.
along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
TCF7L2 mediates canonic Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signaling and c-Myc (Montrer MYC Protéines) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) to c-Myc (Montrer MYC Protéines) axis can be explored for preventing and treating heart failure.
These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.
Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.
In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.
Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.
This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (Montrer WNT2 Protéines) signaling in the intestine during zebrafish organogenesis.
XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (Montrer CHRD Protéines) in organizer cells at the gastrula stage
regulation of XTcf-4 by canonical wnt (Montrer WNT2 Protéines)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (Montrer HNF4A Protéines) binding site within its own promoter
a considerable connection of DEFB1 (Montrer DEFB1 Protéines) and TCF7L2 gene polymorphisms with nephrolithiasis
stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins.
Study showed the association of TCF7L2 SNPs (rs7903146, rs12255372, and rs10885406) with high total cholesterol/high-density lipoproteins ratio. Findings highlight the influence of TCF7L2 SNPs on altered lipid profile in the Balinese, which may further link to the risk of cardiovascular diseases.
TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to diabetic nephropathy in Chinese Han population, but rs290487 is not. The strong linkage disequilibrium existed between the 2 single nucleotide polymorphisms and haplotype T-T (rs7903146-rs290487) increased the susceptibility to diabetic nephropathy.
the T risk allele of the rs7903146 in the TCF7L2 gene increases the risk of type 2 diabetes, was determined.
Common variation at TCF7L2 influences acute responses to both glipizide and metformin in people without diabetes and highlight altered incretin signaling as a potential mechanism by which TCF7L2 variation increases T2D risk.
No correlation between the studied polymorphisms of the TCF7L2 gene and GDM was observed.
Type 1 diabetes mellitus patients carriers of the TCF7L2 variant had a milder immunologic and metabolic phenotype at type 1 diabetes diagnosis, which could be partly driven by type 2 diabetes-like pathogenic mechanisms.
The SNPs in TCF7L2 and HHEX were genotyped by polymerase chain reaction-restriction fragment length polymorphism. There were no significant differences in the distribution of genotypes and alleles between polycystic ovary syndrome cases and controls
TCF7L2 mRNA expression is downregulated in humans with impaired glucose tolerance and adipocyte insulin (Montrer INS Protéines) resistance.
findings report an independent confirmation of the association of the TCF7L2 (Montrer TCF4 Protéines) gene with milk yield and composition traits.
Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (Montrer WFS1 Protéines), FTO (Montrer FTO Protéines), SLC30A8 (Montrer SLC30A8 Protéines), and GCKR (Montrer GCKR Protéines), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
transcription factor 7-like 2 (T-cell specific, HMG-box)
, HMG box transcription factor 4
, T-cell factor 4
, T-cell-specific transcription factor 4
, transcription factor 7-like 2
, transcription factor 7-like 2, T-cell specific, HMG-box
, transcription factor tcf4
, T-cell factor XTCF-4A
, transcription factor Tcf4
, T-cell factor-4 variant A
, T-cell factor-4 variant B
, T-cell factor-4 variant C
, T-cell factor-4 variant D
, T-cell factor-4 variant E
, T-cell factor-4 variant F
, T-cell factor-4 variant G
, T-cell factor-4 variant H
, T-cell factor-4 variant I
, T-cell factor-4 variant J
, T-cell factor-4 variant K
, T-cell factor-4 variant L
, T-cell factor-4 variant M
, T-cell factor-4 variant X2