Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Human TCF7L2 Protein expressed in Wheat germ - ABIN1322376
Shitashige, Satow, Honda, Ono, Hirohashi, Yamada: Regulation of Wnt signaling by the nuclear pore complex. dans Gastroenterology 2008
TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and primary adipocyte stem cells and th (Montrer INS Protéines)at TCF7L2 expression is required for the regulation of Wnt signaling during adipogenesis.
Data (including data from studies in transgenic mice) suggest that inactivation of Tcf7l2 in pancreatic pericytes is associated with impaired expression of genes required for pancreatic beta-cell function and maturity of isolated pancreatic islets. Transgenic mice in which Tcf7l2 is selectively inactivated in pancreatic pericytes exhibit glucose intolerance.
TCF7L2 does not affect oligodendrocyte precursor cells during remyelination.
the inhibition of beta-catenin's TCF (Montrer HNF4A Protéines)-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells.
Findings demonstrate an alpha cell-autonomous role for Tcf7l2 in the control of pancreatic glucagon (Montrer GCG Protéines) secretion and the maintenance of alpha cell mass and function.
Suggest transcription factor 7-like 2 is a possible regulator of glucagon-like peptide 1 receptor (Montrer GLP1R Protéines) expression in endothelial/smooth muscle cells in diabetic mice.
along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
TCF7L2 mediates canonic Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signaling and c-Myc (Montrer MYC Protéines) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) to c-Myc (Montrer MYC Protéines) axis can be explored for preventing and treating heart failure.
These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.
Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.
Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.
In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.
Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.
This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (Montrer WNT2 Protéines) signaling in the intestine during zebrafish organogenesis.
XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (Montrer CHRD Protéines) in organizer cells at the gastrula stage
regulation of XTcf-4 by canonical wnt (Montrer WNT2 Protéines)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (Montrer HNF4A Protéines) binding site within its own promoter
TCF7L2 mRNA expression is downregulated in humans with impaired glucose tolerance and adipocyte insulin (Montrer INS Protéines) resistance.
PGC-1alpha induction during differentiation is required for both mitochondrial biogenesis and commitment to the hepatocytic lineage, and TCF7L2 repression is sufficient to increase PGC-1alpha expression, mitochondrial biogenesis and OXPHOS activity.
Silencing the tcf4 (Montrer TCF4 Protéines) gene confers sensitivity to oxaliplatin in colorectal cancer cells.
GRbeta bound to the N-terminus domain of TCF-4 (Montrer TCF4 Protéines) its influence on Wnt (Montrer WNT2 Protéines) signaling required both ligand- and DNA-binding domains. This is enough to maintain the TCF (Montrer HNF4A Protéines)/LEF activity at a high level in the absence of beta-catenin (Montrer CTNNB1 Protéines) stabilization.
TRIB2 (Montrer TRIB2 Protéines) negatively regulates Wnt (Montrer WNT2 Protéines) activity through a reduction in protein stability of TCF4 (Montrer TCF4 Protéines) and beta-Catenin (Montrer CTNNB1 Protéines)
CtBP physically interacted with TCF-4, and this interaction was significantly inhibited in the presence of MTOB. The above findings point to a novel role of CtBPs in the promotion of CSC growth and self-renewal
Our data revealed that low TCF4 (Montrer TCF4 Protéines) protein expression was a useful predictive factor of good tumor response to nCRT and good outcomes in patients with LARC (Montrer CCL20 Protéines).
These results indicate that a dynamic interplay of TCF (Montrer HNF4A Protéines) transcription factors governs MYC (Montrer MYC Protéines) gene expression in colorectal cancers.
KLF5 (Montrer KLF5 Protéines) facilitates lysophosphatidic acid -induced interaction between beta-catenin (Montrer CTNNB1 Protéines) and TCF4 (Montrer TCF4 Protéines).
The E3 ligase RNF43 (Montrer RNF43 Protéines) inhibits Wnt (Montrer WNT2 Protéines) signaling downstream of mutated beta-catenin (Montrer CTNNB1 Protéines) by sequestering TCF4 (Montrer TCF4 Protéines) to the nuclear membrane.
findings report an independent confirmation of the association of the TCF7L2 (Montrer TCF4 Protéines) gene with milk yield and composition traits.
Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (Montrer WFS1 Protéines), FTO (Montrer FTO Protéines), SLC30A8 (Montrer SLC30A8 Protéines), and GCKR (Montrer GCKR Protéines), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
transcription factor 7-like 2 (T-cell specific, HMG-box)
, HMG box transcription factor 4
, T-cell factor 4
, T-cell-specific transcription factor 4
, transcription factor 7-like 2
, transcription factor 7-like 2, T-cell specific, HMG-box
, transcription factor tcf4
, T-cell factor XTCF-4A
, transcription factor Tcf4
, T-cell factor-4 variant A
, T-cell factor-4 variant B
, T-cell factor-4 variant C
, T-cell factor-4 variant D
, T-cell factor-4 variant E
, T-cell factor-4 variant F
, T-cell factor-4 variant G
, T-cell factor-4 variant H
, T-cell factor-4 variant I
, T-cell factor-4 variant J
, T-cell factor-4 variant K
, T-cell factor-4 variant L
, T-cell factor-4 variant M
, T-cell factor-4 variant X2