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anti-Mouse (Murine) WNT10A Anticorps:
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Human Polyclonal WNT10A Primary Antibody pour ELISA, WB - ABIN1003487
Kelly, Lai, Moon: Expression of wnt10a in the central nervous system of developing zebrafish. dans Developmental biology 1993
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Human Polyclonal WNT10A Primary Antibody pour WB - ABIN541359
Kirikoshi, Sekihara, Katoh: WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. dans Biochemical and biophysical research communications 2001
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Bat Polyclonal WNT10A Primary Antibody pour IHC (p) - ABIN188908
Hakim, Kosmehl, Sieg, Trenkle, Jacobsen, Attila Benedek, Ribbat, Driemel: Altered expression of cell-cell adhesion molecules β-catenin/E-cadherin and related Wnt-signaling pathway in sporadic and syndromal keratocystic odontogenic tumors. dans Clinical oral investigations 2011
WNT10a critical role in the stromagenesis and melanoma growth.
Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific differentiation defects that are mimicked by loss of the transcription factor KLF4.
Deletion of WNT10A resulted in the delayed wound healing associated with suppressed stromagenesis, especially in fibroblasts/myofibroblasts.
The authors conclude that inhibiting DNA methylation by 5-Aza-dC mutual-exclusively regulates the lineage determination of adipogenesis and osteoblastogenesis by demethylating Wnt10a gene and upregulating its expression.
Wnt10a/beta-catenin signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
WNT10A plays an important role in the pathogenesis of IPF via TGF-beta activation and it may also be a sensitive predictor for the onset of an AE-IPF.
Wnt10a regulates proliferation and apoptosis of embryonic palatal mesenchymal cells at least partially through the canonical Wnt/beta-catenin signaling pathway.
Data indicate that that Wnt10a regulates Dspp expression in mesenchymal cells.
Histone methyltransferase G9a represses adipogenesis by inhibiting PPARgamma expression and facilitating Wnt10a expression.
Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors.
WNT10A may be a novel angio/stromagenic growth factor
We performed molecular genetic testing for pathogenetic mutations in the WNT10A gene, which showed a heterozygous missense mutation in exon 2 and exon 4 both leading to amino acid substitution.
In 7 families afflicted with dental anomalies we detected 4 heterozygous missense variants in WNT10B. We performed whole exome sequencing in the patients who had WNT10B mutations and found no mutations in other known hypodontia-associated genes..They also show that WNT10B variants are associated not only with oligodontia and isolated tooth agenesis, but also with microdontia, short tooth roots, dental pulp stones
The study confirmed that Phe228Ile is the most frequent WNT10A variant in Caucasian populations, and that WNT10A mutations are associated with large variability in EDI.
Novel Wnt10A mutations (c.521T>C and c.653T>G) and EVC2 mutation (c.1472C>T) were identified in families with selective tooth agenesis. The Wnt10A c.521T>C mutation and the EVC2 c.1472C>T mutation were considered as pathogenic for affecting highly conserved amino acids, co-segregated with phenotype and predicted to be disease-causing by SIFT and PolyPhen2.
Significant associations were found between individual SNPs and SNP combinations in WNT10A, WNT10B and GREM2 SNPs with isolated tooth agenesis
WNT10A mutations in Schopf-Schulz-Passarge syndrome patients suggest phenotypic expression is not a result of the mutation alone, but is influenced by other currently unknown factors.
The distributions of WNT10A gene rs10177996 SNP among Han nationality in Urumqi area, Uygur nationality in Kashgar area and the reported European population are obviously different.
Polymorphisms in WNT10A is associated with maxillary lateral incisor agenesis.
No up-regulation of Wnt10A and IGF-1 mRNA was observed with 1,550-nm Er:Glass fractional laser treatment of androgenetic alopecia.
WNT10a rs201002930 significantly decreased the risk of cleft lip with cleft palate and cleft palate only.
WNT10A mutation is associated with tooth agenesis.
High WNT10A expression is associated with papillary thyroid carcinoma.
Mild to severe oligodontia was observed in all patients bearing biallelic WNT10A mutations.
The development of maxillary canine, maxillary second molar and mandibular second molar was statistically significantly delayed in patients with WNT10A variants compared with patients without variants. The impact of WNT10A variants on dental development increases with presence of the nonsense c.(321C>A p.(C107*)) variant and the number of missing teeth
Results from genetic analysis revealed that all seven individuals were homozygous or compound heterozygous for WNT10A mutations suggesting that tooth agenesis and/or peg-shaped crowns of primary mandibular incisors, severe oligodontia of permanent dentition as well as ectodermal symptoms of varying severity may be predictors of bi-allelic WNT10A mutations of importance for diagnosis, counselling and follow-up.
miR-378a-3p suppresses hepatic stellate cell activation, at least in part, via targeting of Wnt10a, supporting its potential utility as a novel therapeutic target for liver fibrosis.
risk of hypodontia may be related to the WNT10A polymorphism. Our results also confirm the importance of the Wnt pathway in tooth development.
WNT10A promotes the proliferation of DPCs and negatively regulates their odontoblastic differentiation.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
wingless-type MMTV integration site family, member 10A
, Wnt signaling ligand
, Wnt10a protein
, hypothetical protein
, WNT10A protein
, protein Wnt-10a-like
, protein Wnt-10a
, wingless related MMTV integration site 10a