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anti-Mouse (Murine) WNT16 Anticorps:
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Human Monoclonal WNT16 Primary Antibody pour WB - ABIN967363
Cadigan, Nusse: Wnt signaling: a common theme in animal development. dans Genes & development 1998
Show all 5 Pubmed References
Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1
Wnt16 controls a novel genetic regulatory network required for HSC specification
genomic analysis of conserved sequences between human, rat, and zebrafish WNT16
GC treatment with dexamethasone (DEX) decreased Wnt16 mRNA levels in murine bone marrow stromal cells (mBMSCs) time- and dose-dependently.
WNT16 is a crucial regulator of cortical bone thickness in young adult and old mice. New treatment strategies targeting the adult regulation of WNT16 might be useful to reduce fracture risk at cortical bone sites.
Glucocorticoids (GC) treatment decreases Wnt16 mRNA levels in bone and WNT16 overexpression partly protects against GC-induced bone loss.
A large number of Mef2c targets overlapped with genes down-regulated by Wnt16 and Mef2c itself was transcriptionally repressed by Wnt16 suggesting that Mef2c plays a role in Wnt16-mediated transcriptional regulation.
that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength
WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis.
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
Describe TGFbeta-Wnt16-Notch signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta activity in MGP-null VSMCs as a critical mediator of chondrogenesis.
Wnt5a abrogated the inhibitory effects of Wnt16 on Rankl-induced osteoclastogenesis
These findings suggest that WNT16 acting via canonical WNT signaling regulates mechanical strain-induced periosteal bone formation and bone size.
Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility.
Wnt16 is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/beta-catenin pathway.
Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb.
Study identified two rare variants in functional regions of WNT16 (rs190011371 in WNT16b 3'UTR and rs570754792 in the SOST TATA box) found present in women with low BMD.
there was a significant difference in the genotypic frequencies of rs2707466 between hypertrophic and atrophic hip OA in males, with overrepresentation of G alleles in the hypertrophic phenotype. An association in the same direction was observed between these alleles and the type of knee OA, with G alleles being more common in the hypertrophic than in atrophic knee phenotypes
WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a process enhanced by SFRP2, coordinated by the co-receptor LRP6 but subject to abrogation by DKK1.
the upregulation of autophagy-related gene (Atg) and wingless/int1 (Wnt) signaling during BMP-2-mediated human osteoblastic differentiation, was examined.
PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
ThE findingS suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition.
Although in vitro studies demonstrated no differences in expressions of wild-type and mutant forms of IDUA and WNT16B proteins, in silico analyses predicts that WNT16 rs2707466 directly abolishes a phosphorylation site, which could cause a deleterious effect on WNT16 protein.
MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16
Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content.
ALL cells expressing WNT16 are sensitive to endoplasmic reticulum stress, and show enhanced killing after addition of chloroquine.
loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass.
variants at WNT16 were more strongly related to upper limb-bone mineral density, than to bone mineral density at the other sites.
Increased translation of WNT16 can thus lead to an increased inhibitory action of WNT16 on canonical WNT signaling.
Common missense polymorphisms of the WNT16 gene are associated with bone mineral density at the hip, calcaneal ultrasound and the buckling ratio of the femoral neck, as well as with hip fractures in individuals under 80 years of age.
Estrogen/progesterone treatment of mature myometrial cells induced expression of WNT11 and WNT16, which remained constitutively elevated in leiomyoma tissues.
results suggest synergistic effects of WNT16a insertion and the at-risk 'T' allele of TCF7L2 (rs7903146) for elevating the expression of TCF7L2 in human pancreas which may affect the regulation of downstream target genes involved in the development of T2D
Analyses of femoral neck BMD also supported association with SNPs in WNT16 and ESR1/C6orf97
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
wingless-type MMTV integration site family, member 16
, protein Wnt-16
, protein Wnt-16-like
, wingless-type MMTV integration site family member 16
, wingless-type MMTV integration site family member 16b
, wingless-related MMTV integration site 16