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Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305061
DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. dans The Journal of experimental medicine 1993
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Mouse (Murine) IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305060
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. dans The Journal of experimental medicine 1992
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Human IL12B Protein expressed in Human Cells - ABIN2648866
Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. dans Nature immunology 2015
This data demonstrates that low serum IL-12 levels may be associated with high risk human papillomavirus (hrHPV)susceptibility but are not associated with IL-12 gene polymorphisms; furthermore, IL-12 and IL12R gene polymorphisms may not contribute susceptibility to hrHPV in rural women from Luohe, Henan, China.
Polymorphism rs17860508, a 4bp microinsertion combined with an AA/GC transition, in IL2B promoter region, is not a risk factor for colorectal cancer in Bulgarian patients.
This study shows a preliminary evidence that the amino acid genotype of rs3212227 single nucleotide polymorphism in the IL12B gene might be associated with a lower risk for delayed graft function after kidney transplantation.
High IL-12/23p40 expression is associated with Alzheimer's Disease.
We describe here three new patients with BCG-osis due to complete IL-12p40 deficiency caused by a novel recurrent homozygous mutation of IL12B.
Our results suggest that sex-specific effects of IL12B polymorphisms, rs17860508 and rs3212227, on genetic predisposition and disease course of relapsing-remitting multiple sclerosis , is probably mediated by their gender-dependent functional effect on IL-12p40-containing cytokines.
3' untranslated region A>C (rs3212227) polymorphism of Interleukin 12B gene is associated with Hodgkin's lymphoma.
IL-12 and IL-23 heterodimers are increased in Giant-cell arteritis (GCA) lesions and decrease with glucocorticoid treatment. p19 and p35 subunits are much more abundant than p40, indicating an independent role for these subunits or their potential association with alternative subunits.
Study in family members of Egyptian hepatitis C virus (HCV) infected patients revealed that IL-12B gene polymorphism has no role in intrafamilial susceptibility of HCV transmission. The distribution of the functional 1188 A\C polymorphism of IL-12B gene for C/C, A/C and A/A genotypes was not significantly different among the studied groups.
Sialidase-deficient Porphyromonas gingivalis strain is more easily cleared by attenuating CR3 activation, reducing the inhibition of lncRNA GAS5, inducing less miR-21 and more IL-12 in macrophages.
IL-6 might promote the immune response to hepatitis B vaccination in infants whose mothers were HBsAg-positive, while IL-12 might inhibit the immune response. IL-6 and IL-12 would affect the immune response to hepatitis B vaccination in infants of HBsAg-positive mothers at the same time.
Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB.
showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population
Study confirms an association between IL12B and IL23R genetic polymorphism and psoriasis vulgaris (with a protective effect of minor alleles).
IL-12 B gene AA genotype presented more frequently in late stages of Hepatitis C virus chronically ill patients, while, CC genotype had no significant association with staging of liver disease and had low frequency especially in late stages of liver disease.
IL-12 receptor signalling in keratinocytes initiates a protective transcriptional programme that limits skin inflammation.
Frequency of IL-12B AA (rs6871626) genotype was increased in Ankylosing Spondylitis patients. Interleukin IL-12B AA (rs6871626) gene polymorphisms could serve as promising biomarkers for diagnosis and prognosis in Ankylosing Spondylitis patients.
The demonstrated allelic expression imbalance supports the idea that the IL12B risk haplotype confers susceptibility not only to Crohn's disease onset but to also relapse through increased IL12B mRNA expression.
the present study IL-12B gene status was evaluated in 50 new sputum smear-positive pulmonary tuberculosis patients.
The rs17860508 polymorphism in the IL12B promoter region may influence the risk of developing ovarian endometriosis by altering the endometrial expression of IL12B of in Northern Chinese women.
these findings identify CNBP as important regulator of c-Rel-dependent IL-12beta gene transcription and Th1 immunity.
This report shows that in the absence of both STAT6 and IL-12p40 signaling, Leishmania major-infected BALB/c mice remain susceptible to infection but demonstrate higher tolerance to pathogenic threat as they display smaller footpad lesions compared to IL-12p40-/- mice.
In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the IL-6 and IL-12p40.
Results show the overproduction of IL-12/23p40 in dendritic cells, leading to Th1 and Th17 programs in a mouse model of Yersinia enterocolitica-induced reactive arthritis.
this study demonstrates that regulation of IL-12p40 by hypoxia-inducible factor-1alpha controls Th1/Th17 responses to prevent mucosal inflammation
the nuclear localized CA-VI B selectively promotes IL-12 expression by interaction with protein arginine N-methyltransferase 5 (PRMT5), which reduces symmetric dimethylation of histone H3 arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate chromatin accessibility, selectively enhancing c-Rel binding to the Il12b promoter.
The authors found that the expressions of the mRNAs of both IL-12p35 and IL-12p40 were significantly reduced in the oxygen-induced retinopathy retinas compared to that of the room air-raised control. The results suggest that IL-12 plays important roles in inhibiting pathological retinal neovascularization.
High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.(
IL-12p40 depletion in mice could promote ectopic bone formation.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
this study shows that a systemic IL-12 primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 production is inhibited by TLR stimulation from the plasma membrane
Furthermore, IL-12p40-/- mice showed decreased sensitization to inhaled cockroach antigen after PVM infection when compared to wild-type mice.
Irradiation-induced IL-6 can decrease IL-12 production through the inhibition of C-Rel phosphorylation by the IL-6/STAT3 signaling pathway.
The IL-12 response by dendritic cells against S. aureus is highly growth phase dependent.
The study demonstrate a protective role of IL-12Rbeta2 in relapsing-remitting experimental autoimmune encephalomyelitis.
Interleukin-12/23p40 plays an essential role in the development of graft-versus-host disease in mice.
the PI3K pathway mediated IL-12 inhibition but did not interfere with the inhibition of IL-23 or stimulation of IL-10.
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-12p40, IL-1beta, and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1.
The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12]
Lipopolysaccharide stimulation up-regulates the secretion of cytokines, including interleukin-12, by bovine polymorphonuclear neutrophil leukocytes.
study investigated hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS and IL-12p40 genes downstream of p38
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7/8 and TLR-9 stimulation, which could potentially affect their response to vaccination and viral infection.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 subunit p40
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, interleukin-12 subunit beta
, natural killer cell stimulatory factor, 40 kD subunit
, IL-12 p40
, IL-23 subunit p40
, interleukin-12 p40
, interleukin-12 p40 subunit
, IL-12 p40 subunit
, interleukin 12 p40.b
, interleukin 12B
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, interleukin 12 40kDa subunit
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, Interleukin-12 subunit beta