anti-Souris IL12RB1 anticorps pour Flow Cytometry

Recommended IL12RB1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 12 Receptor beta 1 (IL12RB1) Anticorps
  • Il12rb
  • IL12RB1
  • IL-12R
  • CD212
  • IL-12R-BETA1
  • IL12RB
  • IL-12R[b]
  • interleukin 12 receptor subunit beta 1
  • interleukin 12 receptor, beta 1
  • Il12rb1
  • IL12RB1
Reactivité
Souris
119
30
23
1
Hôte
Souris
79
41
22
1
Clonalité
Monoclonal
Conjugué
Cet anticorp IL12RB1 est conjugé à/à la Biotin
10
8
7
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
71
50
34
20
13
8
7
6
4
3
3
2
1
1
1
Options
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N° du produit ABIN2689093
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
9.362139 ABIN4897371 FACS PE Goat IgG AA 32-561 Connectez-vous pour afficher Polyclonal 0
9.362139 ABIN4897369 FACS Fluorescein Goat IgG AA 32-561 Connectez-vous pour afficher Polyclonal 0
1 ABIN596137 FACS CF Goat IgG Extracellular Domain Connectez-vous pour afficher Polyclonal 0
1 ABIN596138 FACS PE Goat IgG Extracellular Domain Connectez-vous pour afficher Polyclonal 0
1 ABIN2287660 FACS PE Goat IgG Connectez-vous pour afficher Polyclonal 0
1 ABIN2287658 FACS Carboxyfluorescein (CFS) Goat IgG Connectez-vous pour afficher Polyclonal 0

General

Antigène Interleukin 12 Receptor beta 1 (IL12RB1) Anticorps
Reactivité Souris
(119), (30), (23), (1)
Hôte Souris
(79), (41), (22), (1)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp IL12RB1 est conjugé à/à la Biotin
(10), (8), (7), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(71), (50), (34), (20), (13), (8), (7), (6), (4), (3), (3), (2), (1), (1), (1)
Pubmed 8 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IL12RB1 anticorps

Détail du antigène IL12RB1 Information d'application Stockage References for anti-IL12RB1 antibody (ABIN2689093) Images
Marque BD Pharmingen™
Attributs du produit The 114 antibody reacts with mouse CD212 (the β1 subunit of IL-12Rβ1), originally termed IL-12Rβ, of the mouse IL-12 receptor complex. The IL-12Rβ1 subunit associates with a β2 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12Rβ2 binds both to IL-12 p40 and IL-12 p35. IL-12Rβ1 is required for high affinity binding of IL-12 but IL-12Rβ2 is required for signaling. IL-12Rβ1 has more recently been described to bind IL-23, a heterodimer formed of the p40 subunit from IL-12, and p19. The cytoplasmic regions of the β1 and β2 subunits contain the box1 and box2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. IL-12Rβ1 are primarily expressed by activated T cells and NK cells. Experiments with IL-12Rβ1 deficient mice have shown that IL-12Rβ1 is necessary for mouse T and NK cell responsiveness to IL-12 p75. The 114 antibody was generated by immunizing IL-12Rβ1 deficient mice of (129 x BALB/c)F1 background with mouse Ba/F3 cells that were stably transfected with IL-12Rβ1.

BD Pharmingen™ Biotin Mouse Anti-Mouse CD212 - Biotin - Clone 114 - Isotype Mouse IgG2a, κ - Reactivity Ms - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogène IL-12Rbeta1 Transfected Cell Line
Clone 114
Isotype IgG2a, kappa
Plasmids, Primers & others

Détail du antigène IL12RB1

Détail du produit anti-IL12RB1 anticorps Information d'application Stockage References for anti-IL12RB1 antibody (ABIN2689093) Images Haut de la page
Antigène
Autre désignation CD212 (IL12RB1 Antibody Extrait)
Sujet Synonyms: IL-12 Receptor β1 chain
Pathways Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation

Information d'application

Détail du produit anti-IL12RB1 anticorps Détail du antigène IL12RB1 Stockage References for anti-IL12RB1 antibody (ABIN2689093) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-IL12RB1 anticorps Détail du antigène IL12RB1 Information d'application References for anti-IL12RB1 antibody (ABIN2689093) Images Haut de la page
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Stock 4 °C
Stockage commentaire Store undiluted at 4°C.

References for anti-IL12RB1 antibody (ABIN2689093)

Détail du produit anti-IL12RB1 anticorps Détail du antigène IL12RB1 Information d'application Stockage Images Haut de la page
Produit citée dans:

Wu, Wang, Gadina, OShea, Presky, Magram: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, 2000

Wang, Wilkinson, Podlaski, Wu, Stern, Presky, Magram: "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." dans: European journal of immunology, Vol. 29, Issue 6, pp. 2007-13, 1999

Gately, Renzetti, Magram, Stern, Adorini, Gubler, Presky: "The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses." dans: Annual review of immunology, Vol. 16, pp. 495-521, 1998

Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, 1998

Wu, Ferrante, Gately, Magram: "Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 4, pp. 1658-65, 1997

Presky, Yang, Minetti, Chua, Nabavi, Wu, Gately, Gubler: "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 24, pp. 14002-7, 1997

Chua, Wilkinson, Presky, Gubler: "Cloning and characterization of a mouse IL-12 receptor-beta component." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 9, pp. 4286-94, 1995

Stahl, Yancopoulos: "The alphas, betas, and kinases of cytokine receptor complexes." dans: Cell, Vol. 74, Issue 4, pp. 587-90, 1993