Profil protéine

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.

Alternative names and synonyms associated with IL12RB2

• interleukin 12 receptor subunit beta 2 (IL12RB2) anticorps
• interleukin 12 receptor, beta 2 (Il12rb2) anticorps
• interleukin 12 receptor subunit beta 2 (Il12rb2) anticorps

• A930027I18Rik anticorps
• Ifnm anticorps
• IL-12RB2 anticorps
• IL12RB2 anticorps

Protein level used designations for IL12RB2

interleukin 12 receptor, beta 2 , interleukin 12 receptor beta-2 , interleukin-12 receptor subunit beta-2 , interleukin-12 receptor subunit beta-2-like , IL-12 receptor subunit beta-2 , IL-12R subunit beta-2 , IL-12R-beta-2 , interferon response to microorganisms , interleukin-12 receptor beta-2 chain , IL-12RB2 , interleukin-12 receptor beta 2 , IL-12 receptor beta-2