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anti-Human IL13 Receptor alpha 1 Anticorps:
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Human Polyclonal IL13 Receptor alpha 1 Primary Antibody pour CyTOF, FACS - ABIN4900025
Kajiwara, Shinazawa, Morishima, Yanagihara: Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood. dans Cellular immunology 2004
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Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour IHC (p) - ABIN1383688
Joshi, Plautz, Puri: Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas. dans Cancer research 2000
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Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour EIA, FACS - ABIN5540413
Kunii, Nemoto, Kanaya, Tsubahara, Shimauchi: Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13. dans Journal of periodontal research 2005
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Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour FACS - ABIN4897071
Kong, Sengupta, Tyler, Bais, Ma, Doucette, Zhou, Sahin, Carter, Brem, Junghans, Sampath: Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2012
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Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour CyTOF, FACS - ABIN4900024
Bellini, Marini, Bianchetti, Barczyk, Schmidt, Mattoli: Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. dans Mucosal immunology 2012
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Human Polyclonal IL13 Receptor alpha 1 Primary Antibody pour WB - ABIN6681910
Du, Ma, Zhu, Li, Wang, Li, Chen, Shang, Zhang, Zhao: Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model. dans European journal of pharmacology 2017
Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour IHC (p) - ABIN1383689
Andrews, Rosa, Daines, Khurana Hershey: Reconstitution of a functional human type II IL-4/IL-13 receptor in mouse B cells: demonstration of species specificity. dans Journal of immunology (Baltimore, Md. : 1950) 2001
Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour FACS - ABIN4897070
Biancheri, Di Sabatino, Ammoscato, Facciotti, Caprioli, Curciarello, Hoque, Ghanbari, Joe-Njoku, Giuffrida, Rovedatti, Geginat, Corazza, MacDonald: Absence of a role for interleukin-13 in inflammatory bowel disease. dans European journal of immunology 2014
Human Monoclonal IL13 Receptor alpha 1 Primary Antibody pour FACS - ABIN4897069
Takenouchi, Hirai, Sakuragi, Yagita, Hamada, Kato: Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2011
IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.
High IL13RA1 expression is associated with Invasive breast Cancer.
in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism.
these data suggest that microRNA-143 suppresses IL-13 activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes
IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair.
required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4
analysis of IL-4 and IL-13 receptors in cancer biology and discussion of pre-clinical and clinical studies pertaining to recombinant immunotoxins designed to target these receptors [review]
review of IL-4 and IL-13 receptor structure, receptor regulation, signaling and experimental therapeutics [review]
Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer.
Data show that high expression of interleukin-4 receptor IL-4Ralpha correlated with increased recurrence, while interleukin-13 receptor IL-13Ralpha1 had an inverse relationship to recurrence and survival in oral cavity squamous cell carcinoma patients.
miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1.
MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1.
Expression of IL-4, IL-4R, and IL-13R are involved in the process of local metastases in colorectal cancer, while IL-13 expression has an impact on survival.
In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease.
In Korean asthmatic children, increased serum IgE level was a multi-locus interaction between IL-4Ralpha, IL-13, IL-13Ralpha1, CD14, and CTLA4 polymorphisms. The combination of CTLA4/IL-13 and IL-13/IL-13Ralpha1 polymorphisms showed strong synergistic effects.
The data provide evidence for codiffusion of IL-4-A647 bound IL-4Ralpha and the type II subunit IL-13Ralpha1 fused to enhanced green fluorescent protein.
the combination of rs3091307 GG/ rs2265753 GG (IL-13/IL-13Ralpha1) conveyed a significantly higher risk for developing atopic dermatitis
These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production
IL-13 receptor alpha 1 (IL-13Ralpha1) dendritic cell are able to take up antigen from the peritoneum and carry it to the the thymus.
Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice.
Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1.
findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice
These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion.
These data establish for the first time a molecular mechanism by which Mac-1 regulates the signaling activity of IL-13 in macrophages.
CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls
IL-13Ralpha1 is a surface marker for M2 macrophages influencing their differentiation and function.
in neonatal mice, IL-12 uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 differentiation
Expression of IL-13Ralpha1 on dopaminergic neurons can increase their susceptibility to oxidative stress-mediated damage, thereby contributing to their preferential loss.
The extracellular and transmembrane domains of the gammaC and interleukin (IL)-13 receptor alpha1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13
IL-13Ralpha1 is the key receptor mediating airway hypersensitivity responses, mucus production, and transforming growth factor (TGF)-beta induction in response to aeroallergens.
The loss of IL-13Ralpha1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes.
a central role for the IL-13/IL-13Ralpha1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of cystic fibrosis transmembrane conductance regulator
peaks of upregulation in allergic bronchial asthma at 6 hours and 3-12 hours after the last antigen inhalation
IL-13R alpha 1 is required for allergen-induced airway hyperreactivity and mucus production but not for alternative macrophage activation.
IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor have direct roles in asthma pathogenesis
Differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity.
in mouse, Il13ra1 is required for allergen-induced airway hyperreactivity, mucus hypersecretion, and fibrosis but not for alternative macrophage activation.
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
, IL-13 receptor subunit alpha-1
, IL-13R subunit alpha-1
, IL13 receptor alpha-1 chain
, bB128O4.2.1 (interleukin 13 receptor, alpha 1)
, cancer/testis antigen 19
, interleukin-13 receptor subunit alpha-1
, interleukin-13-binding protein
, novel cytokine receptor 4
, interleukin 13 receptor alpha 1
, interleukin 13 receptor alpha chain 1
, interleukin 13 receptor, alpha 1
, interleukin-13 receptor subunit alpha-1-like