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anti-Mouse (Murine) IL15 Anticorps:
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Human Monoclonal IL15 Primary Antibody pour FACS - ABIN4897621
Anguille, Van Acker, Van den Bergh, Willemen, Goossens, Van Tendeloo, Smits, Berneman, Lion: Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. dans PLoS ONE 2015
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Human Monoclonal IL15 Primary Antibody pour CyTOF, FACS - ABIN4900390
Marra, Mathew, Grigoriadis, Wu, Kyle-Cezar, Watkins, Rashid, De Rinaldis, Hessey, Gazinska, Hayday, Tutt: IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. dans Cancer research 2014
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Human Monoclonal IL15 Primary Antibody pour CyTOF, FACS - ABIN4900389
Ong, Hamid, Travers, Strickland, Al Kerithy, Boguniewicz, Leung: Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. dans Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Monoclonal IL15 Primary Antibody pour - ABIN1383961
Bernard, Harb, Mortier, Quéméner, Meloen, Vermot-Desroches, Wijdeness, van Dijken, Grötzinger, Slootstra, Plet, Jacques: Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. dans The Journal of biological chemistry 2004
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Human Polyclonal IL15 Primary Antibody pour FACS, WB - ABIN4900388
Tejman-Yarden, Zlotnik, Lewis, Etzion, Chaimovitz, Douvdevani: Renal cells express a functional interleukin-15 receptor. dans Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005
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Human Monoclonal IL15 Primary Antibody pour FACS - ABIN4897620
Ferlazzo, Pack, Thomas, Paludan, Schmid, Strowig, Bougras, Muller, Moretta, Münz: Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. dans Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal IL15 Primary Antibody pour ELISA, WB - ABIN4324547
Schneider, Mohebiany, Ifergan, Beauseigle, Duquette, Prat, Arbour: B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. dans Journal of immunology (Baltimore, Md. : 1950) 2011
Human Polyclonal IL15 Primary Antibody pour Func, IHC (p) - ABIN2474939
Miller: T4 DNA polymerase (gene 43) is required in vivo for repair of gaps in recombinants. dans Journal of virology 1975
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Human Monoclonal IL15 Primary Antibody pour FACS - ABIN4897618
Pangrazzi, Meryk, Naismith, Koziel, Lair, Krismer, Trieb, Grubeck-Loebenstein: "Inflamm-aging" influences immune cell survival factors in human bone marrow. dans European journal of immunology 2017
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (Montrer CD3 Anticorps)(-) CD8 (Montrer CD8A Anticorps)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (Montrer IFNG Anticorps), and that IL-15 elicits IFN-gamma (Montrer IFNG Anticorps) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (Montrer CD8A Anticorps) antigen, IFN-gamma (Montrer IFNG Anticorps)]
These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated allergic airway disease, which can be regulated by CD8 (Montrer CD8A Anticorps)(+) T cells.
IL-15 induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 is associated with the development of important side effects mainly mediated by IFN-gamma (Montrer IFNG Anticorps)-producing T-cells
findings indicated that IL-15 plays an important role in preventing leukemia development.
NK cells activated by IL-4 (Montrer IL4 Anticorps) in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
Genetic ablation of the IL2Rbeta chain on CD8 (Montrer CD8A Anticorps)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (Montrer CD244 Anticorps) and Tim-3 (Montrer HAVCR2 Anticorps); precludes terminal differentiation of highly defective PD-1 (Montrer PDCD1 Anticorps)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (Montrer IL7 Anticorps)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 (Montrer IL2 Anticorps) and IL-15 as instigators of CD8 (Montrer CD8A Anticorps)(+) T-cell exhaustion during chronic viral infe...
aerobic interval training enhanced the anti-inflammatory indices IL-10 (Montrer IL10 Anticorps)/TNF-alpha (Montrer TNF Anticorps) ratio and IL-15 expression in skeletal muscle in tumor-bearing mice.
this study reveals the function of IL-15 in astrocyte survival via Akt (Montrer AKT1 Anticorps) phosphorylation in response to OGD (Montrer FGFR1 Anticorps)-induced damage.
Our new compelling findings have established the critical roles of both IL-7 (Montrer IL7 Anticorps) and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 (Montrer IL7 Anticorps) and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.
results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease
homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment.
this review will focus on IL-15 biology in NK cells and proposes the development novel therapies aimed at this pathway in humans
IL-15 levels were found to be elevated in depressed patients with asthma.
this paper show that IL-15 boosts the function and migration of human terminally differentiated CD8 (Montrer CD8A Anticorps)+ T cells by inducing a unique gene signature
inhibits the Ca(2 (Montrer CA2 Anticorps)+)-induced differentiation of keratinocytes, mainly via the attenuation of Ca(2 (Montrer CA2 Anticorps)+)-stimulated PI3K (Montrer PIK3CA Anticorps)-AKT (Montrer AKT1 Anticorps) signalling
The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33 (Montrer CD33 Anticorps)(+) HL-60 targets and increased NK survival and proliferation.
In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway.
n this study, authors compared the concentrations of IL-15 and IL-7 (Montrer IL7 Anticorps) in the plasma of MDS (Montrer PAFAH1B1 Anticorps) patients (n = 20) compared with that in the plasma of healthy controls (n = 20). Results indicated that exposure to high levels of IL-15 may be involved in the T cell phenotype conversion observed in MDS (Montrer PAFAH1B1 Anticorps).
the critical role played by IL-7 and IL-15 in T cell homeostasis and how these cytokines could be used to improve immune reconstitution after allogeneic SCT.
Downregulation of Hsc70 (Montrer HSPA8 Anticorps), Hsp70 (Montrer HSP70 Anticorps), and IL-15 expression at gene and/or protein levels might support the retention of fertilization products in cases of missed abortion and blighted ovum.
The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of sustained virological response to pegIFN-alpha/RBV therapy.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (Montrer FYN Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) pathways
IFN-gamma (Montrer IFNG Anticorps) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (Montrer IFNG Anticorps) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (Montrer BCL2 Anticorps).
IL 15 generates a dramatic expansion of short-lived memory CD8 (Montrer CD8A Anticorps) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (Montrer CD4 Anticorps)(+) and CD8 (Montrer CD8A Anticorps)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (Montrer CD4 Anticorps) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (Montrer CD4 Anticorps) on memory CD4 (Montrer CD4 Anticorps) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.