Aperçu des produits pour anti-IL15RA (IL15RA) Anticorps

Human Interleukin 15 Receptor, alpha (IL15RA) interaction partners

1. IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation.

2. Data show that the response of NK cells activated by ULBP2 was augmented by an interaction between NKG2D ligand 2 protein (ULBP2)-bound natural killer group 2D (NKG2D) and IL- interleukin 15 receptor (IL-15R).

3. the combination of the oncolytic immunotherapy with anti-PD-1 antibody dramatically improves the therapeutic outcome compared to either anti-PD-1 alone or vvDD-IL15-Ralpha alone

4. Men with the IL-15Ralpha 1775AA genotype spent more time in light intensity physical activity (39.4 +/- 2.4 hr/week) than men with the CC genotype (28.6 +/- 2.3 hr/week, (p = .009).

5. circulating IL-15 and IL-15Ralpha concentrations are reduced in lean and obese physically active people

6. IL-15/IL-15Ralpha signaling pathway is activated in skeletal muscle in response to a session of resistance exercise.

7. IL-15 and IL-15Ralpha genes in samples from the Spanish Consortium for Genetics of Celiac Disease (CEGEC) collection, identifying two regulatory single-nucleotide polymorphisms (SNP) that might be associated with celiac disease

8. this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI enhances antitumor activity of anti-PD-1 treatment and is a promising approach to stimulate host immunity

9. this study describes variants of splicing of IL-15Ra expressed in intestinal epithelial cells, and identifies those variants with the ability of binding IL-15 and following the secretory pathway, as well as determines if any of these variants are regulated by methylation of DNA

10. 15Ralpha/15 complexes represent a potent adjuvant for augmenting the efficacy of adoptive immunotherapy. Such cell-bound or soluble 15Ralpha/15 complexes could be developed for use in combination immunotherapy approaches.

11. Report improved antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15/IL-15Ralpha mRNA-engineered designer DC.

12. The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery.

13. significant association of rs2228059 with ossification of the posterior longitudinal ligament of the spine in Chinese Han population

14. Report Il15Ralpha levels in synovial fluid from rheumatoid arthritis patients.

15. NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Ralpha expression

16. IRF-1 promotes LTx I/R injury via hepatocyte IL-15/IL-15Ralpha production and suggest that targeting IRF-1 and IL-15/IL-15Ralpha may be effective in reducing I/R injury associated with LTx.

17. Coexpression of IL15RA and IL15 was also sufficient to activate peripheral blood mononuclear cells.

18. Circulating levels of IL-15 and IL-15Ralpha seem to reflect visceral distribution of adipose tissue; epicardial fat may be a potential source of both IL-15 and IL-15Ralpha.

19. our study provides strong evidence that the functional IL-15RA rs2228059 A>C polymorphism may contribute to the risk of ESCC.

20. We show that a gene transfer approach using recombinant adenovirus to express IL-15 and IL-15Ralpha in murine TRAMP-C2 prostate or TS/A breast tumors induced antitumor immune responses

Mouse (Murine) Interleukin 15 Receptor, alpha (IL15RA) interaction partners

1. IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation.

2. data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion.

3. these data support that IL15RA plays a cell-autonomous role in osteoblast function and bone mineralization

4. IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes.

5. this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor

6. These data provide additional evidence to implicate IL-15Ralpha as a regulator of skeletal muscle phenotypes through effects on the mitochondrion, and suggest these effects are driven by alterations to the mitochondrial proteome.

7. Spontaneous cage activity was not different and IL-15 protein levels were lower in male and female mIl15ra(fl/fl)/Cre(+) mice.

8. Despite being protected against diet induced obesity, IL-15R alpha knockout mice are hyperglycemic and insulin-resistant.

9. Signaling through IL-15Ralpha regulates the development of gammadelta-17 cells early in ontogeny.

10. IL-15 directly induces pro-oxidative gene expression in primary myogenic cultures. Primary myogenic cultures require IL-15RA to respond to IL-15.

11. lower frequencies of IL-15Ralpha expression in PBMCs of Behcet's disease-like symptomatic mice

12. we found that aging-related functional NK cell deficiency was completely reversed by injecting soluble IL-15/IL-15Ralpha complexes.

13. Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.

14. a greater mitochondrial density and mitochondrial DNA content was found in fast muscles from IL-15-Receptor-alpha KO mice that was not due to the presence of smaller muscle fibers.

15. IL-15 is produced and secreted only as a heterodimer with IL-15Ralpha.

16. IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells.

17. Stage 3 thymic invariant natural killer NKT cells are specifically reduced in IL-15Ralpha-deficient mice, whereas the acquisition of natural killer (NK) receptors occurs at stage 3 IL15-dependent thymic cell development.

18. Different levels of IL-15 trans-presentation are required for different natural killer (NK) cell developmental events to reach full maturation status

19. IL-15 receptor alpha has a role in endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles

20. The disrupted circadian rhythm of temperature and activity in the IL15Ralpha KO mice after LPS suggests that upregulated IL15 receptors may serve a beneficial role to counteract the consequences of neuroinflammation.