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anti-Human IL2 Anticorps:
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Human Monoclonal IL2 Primary Antibody pour FACS, WB - ABIN1383940
de Jong, Brouwer, Kuiper, Hooibrink, Miedema, van Lier: Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets. dans Journal of immunology (Baltimore, Md. : 1950) 1992
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Human Monoclonal IL2 Primary Antibody pour CyTOF, FACS - ABIN4899552
Locci, Wu, Arumemi, Mikulski, Dahlberg, Miller, Crotty: Activin A programs the differentiation of human TFH cells. dans Nature immunology 2016
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Mouse (Murine) Polyclonal IL2 Primary Antibody pour WB - ABIN3043201
Hu, Jing, Wang, Zhang, Yong, Wang: The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D-Galactose-induced aged rat model. dans BMC complementary and alternative medicine 2015
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Rat (Rattus) Polyclonal IL2 Primary Antibody pour WB - ABIN3042519
Zhong, Shen, Sun, Wang, Zhang, Sun: Additive effects of ulinastatin and docetaxel on growth of breast cancer xenograft in nude mice and expression of PGE2, IL-10, and IL-2 in primary breast cancer cells. dans Cancer biotherapy & radiopharmaceuticals 2012
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Human Monoclonal IL2 Primary Antibody pour FACS - ABIN4896310
Arneja, Johnson, Gabrovsek, Lauffenburger, White: Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. dans Journal of immunology (Baltimore, Md. : 1950) 2013
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Human Monoclonal IL2 Primary Antibody pour ICS, Neut - ABIN1176901
Andersson, Abrams, Björk, Funa, Litton, Agren, Andersson: Concomitant in vivo production of 19 different cytokines in human tonsils. dans Immunology 1995
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Mouse (Murine) Monoclonal IL2 Primary Antibody pour FACS, IP - ABIN2689749
Abrams: Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. dans Current protocols in immunology / edited by John E. Coligan ... [et al.] 2008
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Human Polyclonal IL2 Primary Antibody pour ELISA, WB - ABIN5518852
Gong, Wang, Yuan, Li, Gu, Zhao, Zhang, Jia, Feng, Liu: Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of Scutellaria barbata D. Don in Lewis-Bearing C57BL/6 Mice. dans Evidence-based complementary and alternative medicine : eCAM 2015
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Human Monoclonal IL2 Primary Antibody pour FACS - ABIN1383941
North, Webster, Farrant: Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic') and CD28- ('suppressor') CD8+ subsets. dans Clinical and experimental immunology 1998
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Human Monoclonal IL2 Primary Antibody pour FACS - ABIN4896309
Alisa, Ives, Pathan, Navarrete, Williams, Bertoletti, Behboudi: Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2005
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IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
p.81delThr in IL-2 in Hominides superfamily interfered with interaction of IL-2 and IL-2Ralpha and led to overall decrease in lymphocyte counts in this superfamily of primates in comparison with other primates.
there might be a relationship between IL-2 expression levels in CD4+ T cells and rejection episodes in kidney transplant recipients
Measuring IL-2 and IL-8 in the serum may be a surrogate marker of the immunosuppressive status of kidney transplant recipients
Our study shows that miRNA-146a and miRNA-155, in association with TNF-alpha and IL-2, provide pathways involved in the progress of gastritis in neoplastic processes induced by H. pylori infection.
The efficacy of future regimens may be improved by providing posttransfer support with IL2 or IL15.
This study was performed to assess potential association of autoimmune hepatitis with interleukin-2 gene single nucleotide polymorphisms
Among infants, an HSP90B1 gene-region variant is associated with BCG-induced IL-2 production and may be associated with protection from TB disease. HSP90B1 knockdown in human monocyte-like cell lines did not influence TLR2 surface localization nor Mtb replication. Together, these data suggest that HSP90B1 regulates T-cell, but not monocyte, responses to mycobacteria in humans.
Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling.
this reduction in UBASH3A, as a consequence of the minor allele at rs1893592, resulted in increased secretion of IL-2, a key cytokine that is required for T-cell activation and function but is deficient in some type 1 diabetes (T1D). Our study provides new mechanistic insights into how rs1893592 affects T1D and autoimmunity and how interactions between multiple T1D-associated, noncoding variants influence the disease risk
the co-culture with human T lymphocytes induce the in vitro maturation of human intestinal organoids, and identify STAT3-activating interleukin-2 (IL-2) as the major factor inducing maturation.
This study emphasized on the bone marrow and blood plasma levels of IL-2 in aplastic anaemia and their relationship with disease severity. The results indicate towards the fact that IL-2 may have an important association with the marrow failure of AAA patients and thus can help in disease development. Further study is necessary for better understanding.
The present study demonstrated no association between IL-2 (T-330G), IL-16 (T-295C), and IL-17 (A-7383G) genotypes and CP in an Iranian population.
In contrast with some reports involving the correlation between polymorphisms of the TGF-beta1 and IL-2 genes and inhibitor development in the world, no statistically significant differences in analysis of the alleles and genotypes for TGF-beta and IL-2 genes were found between the inhibitor and non-inhibitor Iranian patients
The current study highlights the possible involvement of the IL-2-330T/G Single Nucleotide Polymorphism in susceptibility to B-Cell Non-Hodgkin Lymphoma . Moreover, IL-10-1082A/G is not a molecular susceptibility marker for B-Cell Non-Hodgkin Lymphoma in Egyptians.
interleukin-2 (IL-2) is a non-pancreatic autoimmune target in type 1 diabetes
The IL-2 AC genotype and C allele of IL-2 (-330A>C) gene polymorphisms could be potential protective factors and might reduce the risk of oral cancer in Indian population.
Data show that GIF (ORF117 ) serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2).
CD4(+) T cells showed the greatest increase (threefold) in ORMDL3 expression in individuals carrying the asthma-risk alleles, where ORMDL3 negatively regulated interleukin-2 production. The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus.
The main mechanism of elimination of mesenchymal stromal cells is cytotoxicity of NK cells that depended on IL-2 production.
Uremia patients receiving maintenance hemodialysis with hospitalacquired infection had increased serum inflammatory factors and high throughput hemodialysis significantly decreased CRP, IL2 and TNFalpha levels in the serum, suggesting that high throughput hemodialysis may be beneficial for the prevention of the infections in uremia patients.
Bivariate genomic footprinting elucidated the c-Maf transcription-factor network...and led to the identification and validation of c-Maf as a negative regulator of IL-2.
Here we focus on the cytokines implicated in thymic development of Treg(T lymphocytes (Treg) expressing the transcription factor Foxp3), with a particular emphasis on the roles of interleukin-2 and IL-15
The authors established that OX40L/OX40 interaction was required and sufficient to induce regulatory T-cell proliferation in vivo independent of PKC- status. Although PKC- is dispensable for T-cell receptor-independent regulatory T-cell proliferation per se, it is essential for optimum IL-2 production by effector T-cells.
Study using a mouse model with reduced IL-2 signaling revealed that IL-2, possibly through the positioning of the genome organizer SATB1, modulates thymic-derived Treg cell epigenetic identity prior to Foxp3 expression.
These studies demonstrate that Th1 CD4(+) T cells require IL-2 for lung T resident memory cell development.
Because IL-2 production was limited to cells receiving the strongest T cell receptor (TCR) signals, a direct link between TCR-signal strength, IL-2 production, and T cell fate determination has been established.
These data highlights the existence of IL-2 trans-presentation between NK cells in the local microenvironment where the availability of IL-2 is limited.
Each mutation decreased STAT5 binding and altered IL-2-induced Il2ra gene expression, revealing that individual elements within the superenhancer were not functionally redundant and that all were required for normal gene expression.
Deleting IL-2 in CD11c(high)MHCII(+) cells induces spontaneous colitis resembling human inflammatory bowel disease.
a significant increase in plasma levels of IL-2, IFN-g and TNF-g was revealed as assessed by ELISA. In conclusion, the results of the present study indicate that MENK has a cytotoxic effect on B16 melanoma cells in vitro and in vivo, and suggest a potential mechanism for these bioactivities.
WASp knockout mice controlled growth of A20 lymphoma cells that naturally produced IL-2.
Tumor growth delays observed by tumor irradiation combined with MVA-MUC1-IL-2 vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA empty vector.
IL-2 signalling is essential to prevent deletion of CD4SP CCR7+ Helios+ thymocytes at a later developmental stage than Card11 is required to prevent deletion. The deletion prevented by IL-2 signalling occurs in a Foxp3-independent manner.
in vivo targeting of the TNF superfamily receptor TNFRSF25 using the TL1A-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice; transplantation of Treg-expanded donor cells facilitated transplant tolerance without GVHD, with complete sparing of graft-versus-malignancy.
IL-2 and IL-6 work together to enhance influenza-specific CD8 T cell generation responding to live influenza virus in aged mice and humans
Genetic ablation of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 as instigators of CD8(+) T-cell exhaustion during chronic viral infe...
this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target. Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions.
Data show that PTEN plays a key role in Th17 cell differentiation by blocking IL-2 expression.
AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.
We observed that besides TCR stimulation Tregs require IL-2 for activation.
a parameter of early mRNA expression during intestinal ischemia reperfusion injury
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein