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anti-Human IL21 Anticorps:
anti-Mouse (Murine) IL21 Anticorps:
anti-Rat (Rattus) IL21 Anticorps:
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Human Polyclonal IL21 Primary Antibody pour ICC, IF - ABIN315232
Liu, Xia, Wu, Wu, Tang, Chen, Xu, Cong, Xu, Liu: Anti-tumour necrosis factor therapy enhances mucosal healing through down-regulation of interleukin-21 expression and T helper type 17 cell infiltration in Crohn's disease. dans Clinical and experimental immunology 2013
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Human Polyclonal IL21 Primary Antibody pour ICC, ELISA - ABIN1002621
Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. dans Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Monoclonal IL21 Primary Antibody pour ELISA - ABIN2689755
Leonard, Spolski: Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. dans Nature reviews. Immunology 2005
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Human Monoclonal IL21 Primary Antibody pour ELISA - ABIN2689754
Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. dans Immunology 2004
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Mouse (Murine) Monoclonal IL21 Primary Antibody pour FACS - ABIN4896831
Carrier, Whitters, Miyashiro, LaBranche, Ramon, Benoit, Ryan, Keegan, Guay, Douhan, Collins, Dunussi-Joannopoulos, Medley: Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. dans European journal of immunology 2012
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Mouse (Murine) Monoclonal IL21 Primary Antibody pour FACS - ABIN4896832
Hondowicz, Batheja, Metzgar, Caton, Erikson: ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice. dans Journal of autoimmunity 2010
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Human Polyclonal IL21 Primary Antibody pour IF (p), IHC (p) - ABIN748133
Guan, Wang, Meng, Shi, Jiang, Xiao, Shi, Xu, Zhang: Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease. dans Cytokine 2015
Human Monoclonal IL21 Primary Antibody pour ICC, IF - ABIN4324913
Chen, Xiao, Lao, Wei, Liu, Zeng, Wang, Ouyang, Chen, Chan, Shi, Zheng, Kuang: Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. dans Cancer discovery 2016
Human Polyclonal IL21 Primary Antibody pour IHC (p), WB - ABIN2474979
Tripodo, Gri, Piccaluga, Frossi, Guarnotta, Piconese, Franco, Vetri, Pucillo, Florena, Colombo, Pileri: Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma. dans The American journal of pathology 2010
These results suggest that cetuximab treatment in combination with IL-21 adjuvant therapy in patients with EGFR-positive pancreatic cancer results in significant NK cell activation, irrespective of KRAS mutation status, and may be a potential therapeutic strategy
serum IL-21 (Montrer IL17C Anticorps) levels at 12 weeks treatment was significantly elevated, which can predict the EVR, and contributes to individualization of antiviral therapy in HBeAg-positive CHB+NAFLD (Montrer TSC2 Anticorps) patients.
IL-23 (Montrer IL23A Anticorps) activates gammadelta T cells in early stage PNS, which amplifies the Th17 cell population and leads to kidney injury through the secretion of IL-21 (Montrer IL17C Anticorps).
IL-21 (Montrer IL17C Anticorps) promotes the survival and CTLA-4 (Montrer CTLA4 Anticorps) expression of Tregs and enhanced the suppressive capacity of Tregs during HIV infection. These results broaden the understanding of HIV pathogenesis and provide critical information for HIV interventions.
IL-21 (Montrer IL17C Anticorps) are important in the pathophysiology of chronic rhinosinusitis with nasal polyposis
Data show that interleukin-21-primed cytotoxic T-cell lymphocytes (CTL) with cytotoxic T-lymphocyte associated protein 4 (CTLA-4 (Montrer CTLA4 Anticorps)) blockade is safe and produces durable clinical responses.
These results indicate that significant increased IL-21 (Montrer IL17C Anticorps) expression present within the adenoma/CRC (Montrer CALR Anticorps) microenvironment might have a potential predicating significance for survival time in patients with CRC (Montrer CALR Anticorps).
IL-21 (Montrer IL17C Anticorps) modulates the effector functions of T, B and NK cells, which not only have key roles in antitumoral and antiviral immunity but also in exerting major effects on inflammatory responses promoting the development of autoimmune diseases.
CCL21 (Montrer CCL21 Anticorps)/IL21 (Montrer IL17C Anticorps)-armed oncolytic adenovirus enhances antitumor activity against TERT (Montrer TERT Anticorps)-positive tumor cells.
Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 (Montrer IL2 Anticorps) and engineered K562 cells expressing membrane-bound IL-21 (Montrer IL17C Anticorps) for cancer immunotherapy.
IL-6 (Montrer IL6 Anticorps) is identified as a master regulator of IL-21 in effector CD8 (Montrer CD8A Anticorps)(+) T cells.
Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.
we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21
this study shows that IL-21 acts as a potent inhibitor of a IL-17A (Montrer IL17A Anticorps)-producing T-cell subset during Mycobacterium bovis Bacillus infection
IL-21 may play an important role in the pathogenesis of SSc (Montrer CYP11A1 Anticorps) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM (Montrer BLM Anticorps)-induced systemic sclerosis mouse model via Il21R (Montrer IL21R Anticorps).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (Montrer CD8A Anticorps) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (Montrer IL17A Anticorps)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (Montrer CD4 Anticorps) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (Montrer CD8A Anticorps) T cells is critical for CTL effector maturation whereas a lack of IL-21R (Montrer IL21R Anticorps) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (Montrer IL21R Anticorps), and a series of genes associated with TFH cell development and function.
The results revealed that the peak expression of IL6 (Montrer IL6 Anticorps) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform