anti-Humain IL21 anticorps pour Biochemical Assay

Recommended IL21 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 21 (IL21) Anticorps
  • IL-21
  • Za11
  • interleukin 21
  • IL21
  • Il21
Reactivité
Humain
212
108
29
9
4
4
4
1
1
Hôte
Souris
177
74
39
10
5
Clonalité
Monoclonal
Conjugué
Cet anticorp IL21 est conjugé à/à la PE
24
13
12
12
10
9
6
5
5
5
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
201
138
52
48
33
24
15
13
10
7
6
6
5
4
3
3
2
1
1
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Request

Recevoir ce produit gratuitement

Envoyez-nous votre proposition de validation. J'aimerais valider ce produit

Savoir plus

Images

N° du produit ABIN2663780
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN2665141 BCA Mouse IgG1 kappa Connectez-vous pour afficher 3A3-N2 4
1 ABIN2666226 BCA Mouse IgG1 kappa Connectez-vous pour afficher 7H20-I19-M3 4
1 ABIN2663781 BCA PE Mouse IgG2b kappa Connectez-vous pour afficher 4BG1 6

General

Antigène Interleukin 21 (IL21) Anticorps
Reactivité Humain
(212), (108), (29), (9), (4), (4), (4), (1), (1)
Hôte Souris
(177), (74), (39), (10), (5)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp IL21 est conjugé à/à la PE
(24), (13), (12), (12), (10), (9), (6), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(201), (138), (52), (48), (33), (24), (15), (13), (10), (7), (6), (6), (5), (4), (3), (3), (2), (1), (1)
Pubmed 6 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IL21 anticorps

Détail du antigène IL21 Information d'application Stockage References for anti-IL21 antibody (ABIN2663780) Images
Purification The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Clone 4BG1
Isotype IgG2b kappa
Plasmids, Primers & others

Détail du antigène IL21

Détail du produit anti-IL21 anticorps Information d'application Stockage References for anti-IL21 antibody (ABIN2663780) Images Haut de la page
Antigène
Autre désignation IL-21 (IL21 Antibody Extrait)
Sujet Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Pathways Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response

Information d'application

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Stockage References for anti-IL21 antibody (ABIN2663780) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Information d'application References for anti-IL21 antibody (ABIN2663780) Images Haut de la page
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Protect from prolonged exposure to light. Do not freeze.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL21 antibody (ABIN2663780)

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Information d'application Stockage Images Haut de la page
Background publications

Rahman, Nara, Onoda, Araki, Li, Hoshino, Asao: "Cloning and characterization of an isoform of interleukin-21." dans: FEBS letters, Vol. 581, Issue 21, pp. 4001-9, 2007

Onoda, Rahman, Nara, Araki, Makabe, Tsumoto, Kumagai, Kudo, Ishii, Tanaka, Sugamura, Hayasaka, Asao: "Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets." dans: International immunology, Vol. 19, Issue 10, pp. 1191-9, 2007

Parrish-Novak, Foster, Holly, Clegg: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." dans: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001

Dumoutier, Van Roost, Colau, Renauld: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000

Parrish-Novak, Dillon, Nelson, Hammond, Sprecher, Gross, Johnston, Madden, Xu, West, Schrader, Burkhead, Heipel, Brandt, Kuijper, Kramer, Conklin, Presnell, Berry, Shiota, Bort, Hambly, Mudri, Clegg et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." dans: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000

Images

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Information d'application Stockage References for anti-IL21 antibody (ABIN2663780) Haut de la page
Images (Fournisseur)
Flow Cytometry (FACS) image for anti-Interleukin 21 (IL21) antibody (PE) (ABIN2663780) anti-Interleukin 21 (IL21) antibody (PE)