anti-Souris IL21 anticorps pour Intracellular Flow Cytometry

Recommended IL21 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 21 (IL21) Anticorps
  • IL-21
  • Za11
  • interleukin 21
  • IL21
  • Il21
Reactivité
Souris
213
107
29
9
4
4
4
1
1
Hôte
Rat
177
75
38
10
5
Clonalité
Monoclonal
Conjugué
Cet anticorp IL21 est conjugé à/à la Alexa Fluor 647
24
14
12
12
10
8
6
5
5
5
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
1
Application
Intracellular Flow Cytometry (ICFC)
201
138
52
48
33
24
15
13
10
7
6
6
5
4
4
2
2
1
1
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Request

Recevoir ce produit gratuitement

Envoyez-nous votre proposition de validation. J'aimerais valider ce produit

Savoir plus

Images

N° du produit ABIN2657956
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN2666224 ICFC Biotin Mouse IgG1 kappa Connectez-vous pour afficher 7H20-I19-M3 4
1 ABIN2666225 ICFC Mouse IgG1 kappa Connectez-vous pour afficher 5H3-O12-L23 4

General

Antigène Interleukin 21 (IL21) Anticorps
Reactivité Souris
(213), (107), (29), (9), (4), (4), (4), (1), (1)
Hôte Rat
(177), (75), (38), (10), (5)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp IL21 est conjugé à/à la Alexa Fluor 647
(24), (14), (12), (12), (10), (8), (6), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application Intracellular Flow Cytometry (ICFC)
(201), (138), (52), (48), (33), (24), (15), (13), (10), (7), (6), (6), (5), (4), (4), (2), (2), (1), (1)
Pubmed 8 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IL21 anticorps

Détail du antigène IL21 Information d'application Stockage References for anti-IL21 antibody (ABIN2657956) Images
Purification The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Clone BL25168
Isotype IgG2b
Plasmids, Primers & others

Détail du antigène IL21

Détail du produit anti-IL21 anticorps Information d'application Stockage References for anti-IL21 antibody (ABIN2657956) Images Haut de la page
Antigène
Autre désignation IL-21 (IL21 Antibody Extrait)
Sujet IL-21 is a 17 kD member of the common γ chain family of cytokines and mainly produced by CD4+ T subsets, including Th17, follicular helper T cells (TFH), Th2, memory CD4+ T cells, and NKT cells. IL-21 signals through a heterodimeric receptor complex containing IL-21R and the common cytokine receptor γ chain (CD132). IL-21 has effects on T, B, NK, and myeloid cells, regulates both humoral and cell-mediated immunity. It has been reported that IL-21 is able to enhance the expansion of Th17 cells via the induction of IL-23R, cooperates with IL-7 or IL-15 to promote CD8+ T cell expansion. IL-21 is also known to regulate Ig production by driving the differentiation of B cells to antibody-producing plasma cells and involving in the development of follicular helper T cells (TFH). In addition, IL-21 exerts negative effect on lymphoid and myeloid cells, including induction of B cell apoptosis and inhibition of dendritic cell maturation and function. The type of actions mediated by IL-21 is presumably determined by its biological context, specific activation state of the target cells, as well as the cytokine milieu. IL-21/IL-21R system is involved in the pathogenesis of various autoimmune diseases and anti-tumor effects.
Pathways Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response

Information d'application

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Stockage References for anti-IL21 antibody (ABIN2657956) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Information d'application References for anti-IL21 antibody (ABIN2657956) Images Haut de la page
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Protect from prolonged exposure to light. Do not freeze.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C

References for anti-IL21 antibody (ABIN2657956)

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Information d'application Stockage Images Haut de la page
Background publications

Cedeno-Laurent, Opperman, Barthel, Kuchroo, Dimitroff: "Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 7, pp. 3127-37, 2012

Bauquet, Jin, Paterson, Mitsdoerffer, Ho, Sharpe, Kuchroo: "The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells." dans: Nature immunology, Vol. 10, Issue 2, pp. 167-75, 2009

Pot, Jin, Awasthi, Liu, Lai, Madan, Sharpe, Karp, Miaw, Ho, Kuchroo: "Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 797-801, 2009

Spolski, Kim, Zhu, Levy, Leonard: "IL-21 mediates suppressive effects via its induction of IL-10." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 5, pp. 2859-67, 2009

Suto, Kashiwakuma, Kagami, Hirose, Watanabe, Yokote, Saito, Nakayama, Grusby, Iwamoto, Nakajima: "Development and characterization of IL-21-producing CD4+ T cells." dans: The Journal of experimental medicine, Vol. 205, Issue 6, pp. 1369-79, 2008

Spolski, Leonard: "Interleukin-21: basic biology and implications for cancer and autoimmunity." dans: Annual review of immunology, Vol. 26, pp. 57-79, 2008

Korn, Bettelli, Gao, Awasthi, Jäger, Strom, Oukka, Kuchroo: "IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells." dans: Nature, Vol. 448, Issue 7152, pp. 484-7, 2007

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001

Images

Détail du produit anti-IL21 anticorps Détail du antigène IL21 Information d'application Stockage References for anti-IL21 antibody (ABIN2657956) Haut de la page
Images (Fournisseur)
Flow Cytometry (FACS) image for anti-Interleukin 21 (IL21) antibody (Alexa Fluor 647) (ABIN2657956) anti-Interleukin 21 (IL21) antibody (Alexa Fluor 647)
Flow Cytometry (FACS) image for anti-Interleukin 21 (IL21) antibody (Alexa Fluor 647) (ABIN2657956) anti-Interleukin 21 (IL21) antibody (Alexa Fluor 647) (Image 2)