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study focused on IL-6 (Montrer IL6 Protéines) and activation of its receptors gp80 (Montrer CLU Protéines) and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (Montrer FBXL15 Protéines) Kit, Unifast, and Duralay on control of inflammation
an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation.
The sgp130, IL-6 (Montrer IL6 Protéines), and sIL (Montrer PMEL Protéines)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (Montrer IL6 Protéines) trans-signaling pathway to the pathophysiology of DR.
This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (Montrer HELLS Protéines) consisting of deactivated Cas9 (dCas9) nuclease (Montrer DCLRE1C Protéines) and catalytic domain of the DNA methyltransferase (Montrer DNMT1 Protéines) DNMT3A (Montrer DNMT3A Protéines) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (Montrer HELLS Protéines) of a wider promoter region of the target loci IL6ST and BACH2 (Montrer BACH2 Protéines) decreased their expression
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (Montrer IL6 Protéines) trans-signaling.
Data indicate possible associations between pretransplant levels of CRP (Montrer CRP Protéines)/IL-6 /IL-6 (Montrer IL6 Protéines) receptor /gp130 and posttransplant outcomes.
Soluble glycoprotein 130 and hsp27 (Montrer HSPB1 Protéines) are novel candidate biomarkers for diagnosing Chronic Heart Failure with preserved ejection fraction and thus warrant further investigation; neither dpp4 (Montrer DPP4 Protéines) nor CTSS (Montrer CTSS Protéines) showed promise as biomarkers of Chronic Heart Failure.
Intracellular p19 (Montrer CDKN2D Protéines) associated with the cytokine receptor (Montrer EBI3 Protéines) subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3 (Montrer STAT3 Protéines)) signaling
High serum GP130 levels were associated with Chronic Spontaneous Urticaria.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
Blocking IL-6 (Montrer IL6 Protéines) trans-signaling in the CNS abrogates the ability of IL-6 (Montrer IL6 Protéines) to suppress feeding. Furthermore, gp130 (Montrer LRPPRC Protéines) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (Montrer LRPPRC Protéines) in the PVH attenuates the beneficial central IL-6 (Montrer IL6 Protéines) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (Montrer LRPPRC Protéines)-dependent STAT3 (Montrer STAT3 Protéines) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6/gp130 signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (Montrer LRPPRC Protéines)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (Montrer INS Protéines) resistance.
differences exist in the expression of receptors utilized by the IL-6 (Montrer IL6 Protéines)/gp130 (Montrer LRPPRC Protéines) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (Montrer OSM Protéines) by astrocytes versus microglia
Deregulation of gp130 (Montrer LRPPRC Protéines)/STAT3 (Montrer STAT3 Protéines) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
IL-6sR and gp130 (Montrer ANPEP Protéines), but not IL-6R alpha (Montrer IL6R Protéines), play important roles in regulation of granulosa cell survival
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
, IL-6 receptor subunit beta
, IL-6R subunit beta
, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
, interleukin receptor beta chain
, interleukin-6 receptor subunit beta
, membrane glycoprotein 130
, membrane glycoprotein gp130
, oncostatin-M receptor subunit alpha
, interleukin-6 signal transducer
, interleukin 6 signal transducer
, glycoprotein 130
, LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta
, interleukin 6 signal transducer (gp130, oncostatin M receptor)
, interleukin 6 signal transducer receptor