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anti-Mouse (Murine) Leptin Anticorps:
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Mouse (Murine) Polyclonal Leptin Primary Antibody pour ELISA, WB - ABIN3043294
Cheng, Dai, Dai: Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213. dans Reproductive toxicology (Elmsford, N.Y.) 2010
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Human Polyclonal Leptin Primary Antibody pour ELISA - ABIN545653
Kazumi, Kawaguchi, Hirano, Yoshino: C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. dans Metabolism: clinical and experimental 2003
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Cow (Bovine) Polyclonal Leptin Primary Antibody pour IF (p), IHC (p) - ABIN668243
Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: MicroRNA-126 participates in lipid metabolism in mammary epithelial cells. dans Molecular and cellular endocrinology 2017
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Mouse (Murine) Polyclonal Leptin Primary Antibody pour ELISA, IHC (p) - ABIN5692873
Li, Zhao, Qi, Wang, Zhang, Li, Qin: lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma. dans International journal of oncology 2018
Human Monoclonal Leptin Primary Antibody pour ELISA, IF - ABIN1996123
Sun, Park, Gupta, Holland, Auerbach, Zhang, Goncalves Marangoni, Nicoloro, Czech, Varga, Ploug, An, Scherer: Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. dans Nature communications 2014
Cow (Bovine) Polyclonal Leptin Primary Antibody pour IHC, WB - ABIN2776943
Müller, Kowalewski, Reichler, Kollár, Balogh: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. dans Reproduction in domestic animals = Zuchthygiene 2017
Human Polyclonal Leptin Primary Antibody pour IHC (p), ELISA - ABIN2475317
Paracchini, Pedotti, Taioli: Genetics of leptin and obesity: a HuGE review. dans American journal of epidemiology 2005
GM3-related gangliosides play key roles in leptin and melanocortin signaling
leptin promotes locomotor functional recovery and suppresses neuronal impairment after spinal cord injury (SCI) , suggesting that leptin has a promising clinical therapeutic value for treatment of SCI
Findings identify a key role in thermoregulation for leptin-mediated suppression of thermal conduction via a mechanism that is independent of the thyroid axis.
Thus, leptin increases glucose uptake and enhances insulin signalling in red-type skeletal muscle via activation of sympathetic nerves and beta2-adrenergic receptor in muscle and in a manner independent of muscle AMP-activated protein kinase.
results suggest that the stimulation of D2R increases leptin production and may have a tissue-specific pro-inflammatory effect in adipocytes
We show that these neurons are dispensable for regulating food intake, but are required for coordinating hepatic glucose production and for the fasting-induced fall in leptin levels, independent of changes in fat mass. We also identify a role for sympathetic nervous system regulation of the inhibitory adrenergic receptor (ADRA2A) in regulating leptin production.
Studied role of leptin, iNOS and tenascin C in development of adipose tissue inflammation, extracellular matrix remodeling, and fibrosis in leptin knockout obese mice.
The authors show that the preoptic area leptin-Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis.
Results demonstrated that overexpressed cardiac leptin, coinciding with myocardial ischemia and reperfusion, potentiates myocardial remodeling. This occurs via cardiomyocyte hypertrophy and fibrosis, and leads to augmented post-myocardial infraction heart failure.
We demonstrated here that the in vivo administration of leptin significantly induces neutrophil recruitment to the peritoneal cavity. We propose here that this is an indirect effect of leptin, which requires peritoneal resident cell activation with the production of TNFalpha and CXCL1, mostly by resident monocytes/macrophages.
This study uncovers a developmental function of leptin that may be linked to the pathogenesis of neurological disorders and helps understanding how maternal environment can adversely impact offspring brain development.
Osteopontin overexpression in non-alcoholic steatohepatitis enhances leptin-mediated fibrogenesis via PI3K/Akt.
The study shows a novel role of leptin-induced P2X7r in modulating Glut4 induction and translocation in hepatic stellate cells, that are key to nonalcoholic steatohepatitis progression.
Leptin modulates adventitial pericyte functions by autocrine and paracrine signaling.
In C57bl/6 model, glycaemic index of maternal dietary carbohydrates differentially alters Fto and Lep expression in offspring.
A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models
Catalase overexpression modulates metabolic parameters in a new 'stress-less' leptin-deficient mouse model.
Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin levels and hepatic Angptl6 expression.
This study shows that prolonged exposure to high-fat diets in adulthood is associated with a gradually increasing DNA methylation level at the Leptin and Pparg2 promoters in a depot-specific manner.
the study reports a novel mechanistic pathway of leptin-mediated renal inflammation that is dependent on NOX-2-miR21 axis in ectopic manifestations underlying non-alcoholic fatty liver disease-induced co-morbidities
Serum leptin levels were increased in obese men.
Serum leptin is not directly related to blood pressure and hypertension, and the positive correlation between them may be explained largely by BMI and WHtR [waist-to-height ratio]
Leptin serum levels increased significantly with progression of chronic kidney disease.
Elevated levels of leptin, possibly in association with adiposity and lessened levels of zinc and tryptophan, impact the progression of obesity and mey contribute to the occurrence of sleep disorders.
Serum leptin may be related to the rate of fibrosis progression in nondiabetic patients with chronic HBV infection. Follow-up by serial measurement of serum leptin and HOMA-IR in non diabetic HBV-infected patients may be used as a non-invasive marker of early liver fibrosis.
This study showed that AA carriers of rs2278815 may be less susceptible to weight gain during LA, which makes this SNP a promising biomarker for clinical risk assessment and prediction of adverse effects.
Studied possibility of using pediatric body mass index as a biomarker for obesity due to leptin, leptin receptor, and melanocortin 4 receptor (MC4R) deficiency. Data showed that early childhood BMI is useful in distinguishing between patients with a functional relevant homozygous or compound heterozygous mutation in leptin or leptin receptor gene from patients with a heterozygous mutations in MC4R gene.
we detected that (1) maternal rs10954173 and fetal rs10244329 were associated with maternal fasting plasma insulin (FPI) although the effect of fetal rs10244329 may be not independent of maternal rs10244329, and (2) maternal rs12537573 was associated with maternal FPI and Homeostatic model assessment of insulin resistance.
findings demonstrated that ERalpha, but not ERbeta, is involved in leptin-induced ovarian cancer in an E2-independent manner, providing new evidence for cancer progression in obesity-associated ovarian cancer.
Leptin may up-regulate IL-6 production in vitro by binding with Ob-Rb in TMJ-SFs via the activation of the JAK2/STAT3, p38 MAPK or PI3K/Akt signalling pathways.
Adiponectin and leptin did not correlate with the stage of ovarian cancer and response to chemotherapy (paclitaxel/ carboplatin with or without bevacizumab).
findings provide evidence to support the hypothesis that functional ADIPOQ and LEP gene polymorphisms are associated with susceptibility to multiple sclerosis and its clinical forms.
Data clearly demonstrate that leptin is strongly involved in systemic autoimmune mechanisms and represents a valuable serological marker of systemic rheumatic diseases. [review]
Leptin and insulin levels were positively associated with cord blood mtDNA content.
Findings suggest that leptin (LEP) could be involved in the interplay between obesity and infertility [Review].
REVIEW: Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity
Individuals who drink less tea, carry AA genotype and have high serum leptin are more susceptible to cholesterol gallstones.
adipocyte-derived IL-6 and leptin promote PLOD2 expression by activating the JAK/STAT3 and PI3K/AKT signaling pathways
mechanisms for leptin and ghrelin regulation of tolerogenic functions of dendritic cells in pregnancy
The higher levels of leptin in the overweight and obese pregnant women seem to reflect the leptin resistance.
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.
Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.
These results indicate that leptin and its receptors are expressed in porcine luteal cells and suggest that estradiol and progesterone affect leptin mRNA expression and leptin secretion during the mid-luteal phase of the estrous cycle.
results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake
Linkage disequilibrium analysis among MC4R, LEP and H-FABP revealed that these genes were independent.
role of transcription factor p53 and the metabolic hormone leptin, in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells
The expression levels of leptin in the ovary during mid- and late-luteal phase of the oestrous cycle as well as during days 14-16 and 30-32 of pregnancy is reported.
These results suggest that SNP G-2863A is a potential DNA marker for backfat thickness and has a regulatory role in leptin transcription.
Increases in epicardial perivascular adipose tissue leptin exacerbate coronary endothelial dysfunction in MetS via a PKC-beta-dependent pathway.
These results indicate that both leptin and OB-Rb are synthesized in the porcine hypothalamus and participate in control of reproduction during the oestrous cycle and early pregnancy.
Consistent with this, leptin enhanced GnRH-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY) release.
It is an important regulator of metabolic efficiency, energy expenditure, food intake and body fat mass.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
Results indicated that leptin R25C genotype impacted most traits associated with fatness whereas feeding zilpaterol for 21 d affected weight gain positively but impacted other variables negatively.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin and receptor gene markers would be useful for marker-assisted selection.
A significant positive relationship exists between the T allele frequency in the bovine leptin C/T SNP and animal backfat, with TT, CT and CC animals having estimates of 6.79 +/- 0.02, 6.49 +/- 0.01 and 6.28 +/- 0.01 mm, respectively.
The impact of different alleles of DGAT1 and leptin on milk production in Giorlando cattle is reported.
The effects of dietary energy on the metabolism of ghrelin, leptin and growth hormone secretagogue receptor in blood and tissues of steers are reported.
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin.
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL, LEP, ADIP, INS and CORT concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of