Aperçu des produits pour Leptin Receptor Protéines (LEPR)

Human Leptin Receptor (LEPR) interaction partners

1. Studied association of genetic polymorphisms in fatty acid binding protein 2, leptin receptor, and fat mass and obesity-associated protein with weight loss in obese individuals who had undergone bariatric surgery.

2. Low LEPR expression is associated with Meningioma.

3. Overexpression of leptin and LEPR improved the therapeutic efficacy of neoadjuvant chemotherapy for patients with breast cancer, especially for those with HER2+ subtype. Overexpression of leptin and LEPR was distinct among the different molecular subtypes of breast cancer.

4. there was no association of LEPR-rs1137101 with total energy intake and percentage of energy from macronutrients or ultra-processed foods in pregnant women

5. LEPR K109R might be a susceptible factor for NAFLD in Southeast Asian population. And LEPR Q223R might be a susceptible factor for NAFLD in Chinese population.

6. C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor.

7. Studied possibility of using pediatric body mass index as a biomarker for obesity due to leptin, leptin receptor, and melanocortin 4 receptor (MC4R) deficiency. Data showed that early childhood BMI is useful in distinguishing between patients with a functional relevant homozygous or compound heterozygous mutation in leptin or leptin receptor gene from patients with a heterozygous mutations in MC4R gene.

8. findings demonstrated that ERalpha, but not ERbeta, is involved in leptin-induced ovarian cancer in an E2-independent manner, providing new evidence for cancer progression in obesity-associated ovarian cancer.

9. High expression of Leptin and Its Receptor is associated with Astrocytoma and Oligodendroglioma.

10. In ethnic groups with essential hypertension (EH), LEPR rs1137101 locus is associated with EH among ethnic Hans, while LEPR rs7555955 locus is associated with EH among ethnic Mongolians.

11. Waist/hip ratio (W/H ratio), leptin serum levels and triglycerides appeared to be associated with PCOS but, aside from W/H ratio (AA s GG p = 0.009), this association also occurred for controls. No significant association in the leptin gene polymorphic locus rs1137101 with PCOS was seen in the results of the present study. In the control group, BMI, W/H ratio, leptin, Insulin, and HOMA-IR were significantly higher in the

12. Novel LEPR mutations have been identified in Pakistani families with morbid childhood obesity.

13. Leptin and SLeptinR[ serum Leptin receptor] are independently and inversely associated with GDM [of gestational diabetes mellitus]. Lower levels of these peptides may play an important role in the pathophysiology of GDM and pre-diabetic state in post-puerperium.

14. Loss-of-function mutation in the LEPR segregated with early-onset severe obesity and hyperphagia in an extended consanguineous family.

15. A significant association between LEPR single nucleoitde polymorphism rs8179183 and overweight/obesity in Chinese Han adolescents.

16. LEP 3'UTR A/C and LEPR K109R polymorphisms were associated with Leptin levels and obesity in Tunisian volunteers.

17. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median. The risk allele (G) of variant rs1177681 was also associated with excess weight in subjects with a daily frequency of refined cereal consumption above the median.

18. we report several associations between maternal and fetal LEPR common SNPs and gestational glycemic traits. These associations were nominally significant before correction for multiple comparisons.

19. reveal that breast cancer stem cell (BCSC) in triple-negative breast cancer depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.

20. LEPR rs1137101 and PPARG-2 rs1801282 had weak and medium negative effects on zBMI, respectively, and may slightly protect against childhood obesity.

Mouse (Murine) Leptin Receptor (LEPR) interaction partners

1. Endothelial leptin/Akt/mTor signaling contributes to cardiac fibrosis and functional deterioration by suppressing endothelial autophagy and promoting endothelial dysfunction in a chronic pressure overload model.

2. These results suggest a mechanism for leptin resistance through activation of Mmp-2 and subsequent cleavage of the extracellular domain of the leptin receptor.

3. Findings reveal a compensatory role for hepatic LEPR in HCC development of IL-6Ralpha-deficient mice and suggest hepatocyte-specific leptin signaling as promoter of HCC under obese conditions.

4. LepR expression is required for the full anorexic effect of amylin; however, the neuronal activation in the area postrema seems to depend on the type of LepR mutation.

5. The dysfunction caused by LEPR deletion in somatotropes begins as early as neonatal development and involves developing GH and prolactin cells (somatolactotropes).

6. Insulin and leptin do not exert redundant control of dopamine neuron-mediated modulation of energy balance. Furthermore, neither leptin nor insulin plays a critical role in the modulation of dopamine neurons regarding hedonic feeding behavior or anxiety-related behavior.

7. Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.

8. LepR mutation could result in follicle loss and activation of PTEN/PI3K/Akt/mTOR pathway in adult female mice, independent of insulin signaling pathway.

9. Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes hyperphagia with body weight gain.

10. The authors show that the preoptic area leptin-Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis.

11. These lines of evidence suggest that downregulation of Ob-R and kisspeptin/GPR54 in the murine hypothalamus may contribute to male hypogonadism caused by high-fat diet-induced obesity.

12. Knockin of Lepr in beta cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia.

13. Abnormal sex hormone levels of Y123F mice were due to not only decreased gonadotropin levels in the central nervous system, but also ovarian hormone synthase abnormalities in the peripheral gonads.

14. Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.

15. Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin-receptor (Lep/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3) in hypothalamic neurons.

16. Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin signaling.

17. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus.

18. Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake.

19. This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals.

20. Neurotensin-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.

Pig (Porcine) Leptin Receptor (LEPR) interaction partners

1. polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs

2. study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function

3. LEPR showed a lower variability than LEP in the different analysed populations, especially in the Iberian breed that showed no variability

4. Superactive human leptin antagonist reverses leptin-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin receptors.

5. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

6. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

7. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

8. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin

9. Leptin and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

10. These data suggest that leptin might have a direct effect on porcine follicles and plays an important role in the follicular development.

11. Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.

12. results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake

13. These results of the current study indicated that the c.2002C>T SNP of LEPR has a strong effect on BF, fat area ratios and LEPC.

14. The differences in luteal function in leptin resistance genotype and lean genotype swine due to leptin receptor polymorphism are reported.

15. Conceptus viability and growth were found to be related to the placental expression of the vascular endothelial growth factor A (VEGFA) and leptin (LEP) genes.

16. A polymorphism in LEPR decreased the yield of premium cuts of meat.

17. 87C>T polymorphism is associated with body weight and back fat thickness

18. The objective of this study was to investigate the effect of FABP3 and LEPR genetic variations as well as their mRNA expression on the intramuscular fat content trait in a three-generation of Korean native pig and Yorkshire crossed animals.

19. These results indicate that both leptin and OB-Rb are synthesized in the porcine hypothalamus and participate in control of reproduction during the oestrous cycle and early pregnancy.

20. Data show that treatment with GH or IGF-I reduced leptin receptor expression, and increased Phosphorylation of ERK1/2 in response to acute leptin.

Cow (Bovine) Leptin Receptor (LEPR) interaction partners

1. Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively.

2. I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression

3. The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

4. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

5. The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

6. The leptin and receptor gene markers would be useful for marker-assisted selection.

7. The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.

8. The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.

9. the possible involvement of locally produced leptin/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.

10. findings indicate that acetate and butyrate enhance leptin expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries

11. leptin receptor is expressed in the bovine corpus luteum and is modulated by leptin.

12. The results demonstrated that each Ob-R isoform mRNA was differentially expressed in various tissues of cattle, which may be involved in the difference of peripheral actions for leptin.

13. Lep may regulate gonadotroph function through autocrine/paracrine pathway in the bovine adenohypophysis.

14. Polymorphism in LEPR did not affect significantly any of the traits studied here: daily milk production, feed intake, and feed conversion, and weekly measures of live weight, BCS, or body energy traits

15. the LEPR gene is a strong candidate gene that affects growth traits in cattle.

Rhesus Monkey Leptin Receptor (LEPR) interaction partners

1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).