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Human Leptin Receptor Protein expressed in Human - ABIN593497
Sato, Schehr, Ikegami: Leptin does not influence surfactant synthesis in fetal sheep and mice lungs. dans American journal of physiology. Lung cellular and molecular physiology 2011
Skeletal muscle leptin (Montrer LEP Protéines) receptors are up-regulated in response to severe energy deficit.
The leptin receptor polymorphism seems to affect neuroendocrine regulation of energy balance among adolescents with obesity.
Elevated serum leptin (Montrer LEP Protéines) level could be a predictor for arterial stiffness in hypertension patients.
LEP and LEPR single-nucleotide polymorphisms are not associated with genetic susceptibility to systemic lupus erythematosus.
Studied adiponectin (ADIPOQ), leptin (LEP (Montrer LEP Protéines)), leptin receptor (LEPR), and resistin (RETN (Montrer RETN Protéines)) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522CLEP (Montrer LEP Protéines) 2548GRETN (Montrer RETN Protéines) 420C
Study found an association between LEPR expression and malignant behavior of upper tract urothelial carcinoma. High LEPR expression is independently associated with poor recurrence-free and progression-free survival.
Mendelian randomization study estimating the causal effect of leptin (Montrer LEP Protéines) on Alzheimer disease (AD) did not find an effect of genetically predicted circulating leptin (Montrer LEP Protéines) and sOB-R levels on AD. As such, this study suggests that leptin (Montrer LEP Protéines) is unlikely to be a major contributor to AD, although the wide confidence intervals preclude a definitive assessment.
Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin (Montrer INS Protéines) Resistance in Spanish Female Obese Children.
Leptin (Montrer LEP Protéines), and leptin receptor polymorphisms and breast cancer risk in a Chinese cohort of women.
We demonstrate that leptin (Montrer LEP Protéines) stimulates the phosphorylation of STAT3 (Montrer STAT3 Protéines) in LEPRb-transfected non-cancer stem cells (CSCs) compared with non-transfected non-CSCs. The increased expression of LEPRb and STAT3 (Montrer STAT3 Protéines) activation recapitulated the phosphorylation status of STAT3 (Montrer STAT3 Protéines) in CSCs. Our data demonstrate that LEPRb-induced STAT3 (Montrer STAT3 Protéines) activation is essential for the induction and maintenance of triple-negative breast cancer CSCs.
Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin (Montrer LEP Protéines)-receptor (Lep (Montrer LEP Protéines)/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep (Montrer LEP Protéines)/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3 (Montrer ATF3 Protéines)) in hypothalamic neurons.
Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin (Montrer LEP Protéines) receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin (Montrer LEP Protéines) signaling.
The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus.
Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake.
This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals.
Neurotensin (Montrer NTS Protéines)-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.
Suggest that intact endothelial leptin (Montrer LEP Protéines) signaling limits neointima formation and that obesity represents a state of endothelial leptin (Montrer LEP Protéines) resistance.
Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (Montrer PDGFRA Protéines) signalling could be an effective way to treat bone marrow fibrosis.
Leptin (Montrer LEP Protéines) expression is regulated by DNA methylation (Montrer HELLS Protéines) in adipocytes.
Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1 (Montrer PRDM1 Protéines)).
polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
LEPR showed a lower variability than LEP (Montrer LEP Protéines) in the different analysed populations, especially in the Iberian breed that showed no variability
Superactive human leptin (Montrer LEP Protéines) antagonist reverses leptin (Montrer LEP Protéines)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (Montrer LEP Protéines) receptors.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (Montrer LEP Protéines)
Leptin (Montrer LEP Protéines) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (Montrer LEP Protéines) mRNA expression as well as E and P on leptin (Montrer LEP Protéines) secretion by those cells obtained in early pregnancy.
These data suggest that leptin (Montrer LEP Protéines) might have a direct effect on porcine follicles and plays an important role in the follicular development.
Here, the association between DGAT1 (Montrer DGAT1 Protéines) K232A, SCD1 (Montrer SCD Protéines) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (Montrer DGAT1 Protéines), SCD1 (Montrer SCD Protéines), and LEPR polymorphisms were GC/GC (Montrer GC Protéines), C, and C, respectively.
I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
The use of leptin (Montrer LEP Protéines), leptin receptor, and DGAT1 (Montrer DGAT1 Protéines) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin (Montrer LEP Protéines) and receptor gene markers would be useful for marker-assisted selection.
The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.
The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.
the possible involvement of locally produced leptin (Montrer LEP Protéines)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.
findings indicate that acetate and butyrate enhance leptin (Montrer LEP Protéines) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries
A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
, Leptin receptor (fatty)
, leptin receptor gene-related protein
, cytokine receptor
, leptin receptor long insert isoform
, leptin receptor