anti-MPL Anticorps

Profil protéine

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Alternative names and synonyms associated with MPL

• MPL proto-oncogene, thrombopoietin receptor (MPL) anticorps
• myeloproliferative leukemia virus oncogene (Mpl) anticorps
• MPL proto-oncogene, thrombopoietin receptor (Mpl) anticorps
• MPL proto-oncogene, thrombopoietin receptor (mpl) anticorps

• c-mpl anticorps
• c-mpl-I anticorps
• c-mpl-II anticorps
• CD110 anticorps
• hlb219 anticorps
• Afficher tous les alias de synonymes
• MPL anticorps
• mpll anticorps
• MPLV anticorps
• THCYT2 anticorps
• TPO-R anticorps
• tpor anticorps
• tpor.b anticorps

Protein level used designations for MPL

TPO-R , myeloproliferative leukemia protein , proto-oncogene c-Mpl , thrombopoietin receptor , myeloproliferative leukemia virus oncogene , thrombopoietin receptor-like , cytokine receptor , myeloproliferative leukemia virus oncogene, like , thrombopoietin receptor c-mpl