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Polymorphisms of the OSMR rs2292016 locus are related to the development and outcome of DCM.
Missense mutatios were found in exon 10 of the oncostatin-M specific receptor beta subunit (OSMR) gene in all of the six patients from family 1, and in exon 14 of the OSMR gene in all of the four patients from family 2.
The PLAC1 (Montrer PLAC1 Protéines) expression has been demonstrated for the first time in cervical cancers. This preliminary study has further revealed a complex relationship between PLAC1 (Montrer PLAC1 Protéines) expression, cervical cancer histologic type, p53 (Montrer TP53 Protéines), and HPV type that requires further investigation.
OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability
OSM and OSMR are highly expressed in inflammatory bowel disease intestinal mucosa compared to control mucosa. Intestinal stromal cells express abundant OSMR.
OSM:OSMR interactions are able to induce EMT (Montrer ITK Protéines), increased cancer stem cell-like properties and enhanced lung colonisation in SCC (Montrer CYP11A1 Protéines) cells
the RET (Montrer RET Protéines) p.S891A mutation combined with OSMR p.G513D may underlie a novel phenotype manifesting as familial medullary thyroid carcinoma and cutaneous amyloidosis
this study offers new findings on the molecular genetics and disease relevance of mutations in OSMR in Familial primary localized cutaneous amyloidosis.
Oncostatin M (Montrer OSM Protéines) and interleukin-31 (Montrer IL31 Protéines): Cytokines, receptors, signal transduction and physiology.
primary localized cutaneous amyloidosis has a missense mutation in oncostatin M receptor beta
Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis.
In astrocytes but not microglia, phosphorylation of STAT1 (Montrer STAT1 Protéines) and STAT3 (Montrer STAT3 Protéines) occurred in response to OSM (Montrer OSM Protéines), whereas both microglia and astrocytes responded to hyper-IL-6 (IL-6 (Montrer IL6 Protéines) linked to the soluble IL-6 (Montrer IL6 Protéines) receptor).
OSM (Montrer OSM Protéines) signaling via OSMR in synovial fibroblasts has the potential to contribute significantly to joint destruction in inflammatory arthritis.
defects in OSM (Montrer OSM Protéines) signaling promote the deterioration of high-fat diet-induced obesity and related metabolic disorders
Data indicate that OSM (Montrer OSM Protéines) receptor beta subunit (Montrer POLG Protéines)-deficient (OSMRbeta(-/-)) mice exhibited phenotypic changes in adipose tissue macrophages (ATMs) to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin (Montrer INS Protéines) resistance.
These data indicate that the transient RANKL (Montrer TNFSF11 Protéines) induction by intermittent PTH (Montrer PTH Protéines) administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction.
Bone formation can be stimulated independently of bone resorption and provide new insights into OSMR signaling.
Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IL-31 receptor subunit beta
, IL-31R subunit beta
, interleukin-31 receptor subunit beta
, oncostatin-M specific receptor beta subunit
, oncostatin-M-specific receptor subunit beta
, oncostatin receptor
, oncostatin-M specific receptor subunit beta
, oncostatin M specific receptor