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Human SOCS3 Protein expressed in Wheat germ - ABIN1320930
Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. dans Molecular vision 2014
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (Montrer STAT3 Protéines)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (Montrer TRPM7 Protéines) regulates exocrine pancreatic development via the Mg(2 (Montrer MCOLN1 Protéines)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (Montrer MAPK1 Protéines) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (Montrer SOCS1 Protéines) and SOCS3 proteins.
Low SOCS3 expression is associated with invasion and lymph node metastasis in gastric cancer.
Results show the CAT haplotype in SOCS3 was associated with metabolic syndrome (MetS (Montrer ETV3 Protéines)) in Mexican Mestizos, and type 2 diabetes in Mexican Amerindians.
SOCS3 overexpression decreased JAK (Montrer JAK3 Protéines)-STAT3 (Montrer STAT3 Protéines) signaling pathway activity, declined Bcl-2 (Montrer BCL2 Protéines) expression, inhibited cell proliferation, elevated cell apoptosis, and enhanced Adriamycin sensitivity in T24 cells
miR203 expression may be upregulated by IL17 (Montrer IL17A Protéines) stimulation, and miR203 is a positive regulator of IL17induced VEGF (Montrer VEGFA Protéines) secretion.
SOCS3 DNA methylation (Montrer HELLS Protéines) is associated with body weight and moderates the effect of cumulative stress on obesity.
SOCS3 was targeted by miR30a- 5p in allergic rhinitis
Cellular viability was significantly decreased, whereas IL6 (Montrer IL6 Protéines) and TNFalpha (Montrer TNF Protéines) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.
this study shows that Nrf2 (Montrer GABPA Protéines) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (Montrer JAK2 Protéines)/STAT3 (Montrer STAT3 Protéines) cascade
SOCS-1 (Montrer SOCS1 Protéines), SOCS-2 (Montrer SOCS2 Protéines), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Our study showed that the expressions of HER2 (Montrer ERBB2 Protéines), STAT3 (Montrer STAT3 Protéines), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (Montrer ERBB2 Protéines) and STAT3 (Montrer STAT3 Protéines) and lower expression of SOCS3 predict poor prognosis of OC.
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 (Montrer STAT3 Protéines) and TNF receptor-associated factor 2 (Montrer TRAF2 Protéines), suggesting mechanisms by which SOCS3 inhibits IL-6 (Montrer IL6 Protéines) and TNF-alpha (Montrer TNF Protéines) signaling.
SOCS3 is an important negative regulator of insulin (Montrer INS Protéines) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (Montrer IL10 Protéines) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Our findings suggest a role for murine cytomegalovirus (MCMV)-related stimulation of SOCS1 (Montrer SOCS1 Protéines) and SOCS3 in the progression of retinal disease during ocular, but not systemic, MCMV infection.
Lentivirusmediated overexpression of SOCS3 was revealed to ameliorate neutrophilic airway inflammation by inhibiting pulmonary Th17 responses in mice with chronic Pseudomonas aeruginosa lung infections.
These data demonstrate that loss of SOCS3 in cardiomyocytes promotes deoxycorticosterone-acetate -salt-induced cardiac remodeling and inflammation.
In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation.
SOCS3 was upregulated in lung CD4 (Montrer CD4 Protéines)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (Montrer IL6 Protéines) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (Montrer TCF3 Protéines) activated expression of the transcription factor Spi-B (Montrer SPIB Protéines) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (Montrer FOXP3 Protéines) expression. These findings demonstrate that the balance of Id3 (Montrer ID3 Protéines) and E47 (Montrer TCF3 Protéines) controls the maintenance of Foxp3 (Montrer FOXP3 Protéines) expression in Treg cells and, thus, contributes to Treg cell plasticity.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3