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Src kinase (Montrer CSK Protéines) activation by nitric oxide promotes resistance to anoikis in tumor cell lines.
RANKL (Montrer TNFSF11 Protéines) and Src has an unrecognized role in osteocyte survival.
These interactions are required for SRC-induced activation of VAV (Montrer VAV1 Protéines) and the subsequent engagement of a JIP1 (Montrer MAPK8IP1 Protéines)-tethered JNK (Montrer MAPK8 Protéines) signaling module.
Elevated retinoic acid-inducible gene 1 (Montrer RARRES3 Protéines) (RIG-I (Montrer DDX58 Protéines)) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 (Montrer STAT3 Protéines) by competitive binding to STAT3 (Montrer STAT3 Protéines).
Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src
unlike c-fos-/- mice, c-src-/- mice demonstrated activated, mature osteoblasts, and parallel layers of cement lines in the superficial bone matrix, indicating the new bones were piled up to older bone.
TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.
We conclude that pp60(Src) can directly inhibit DDAH (Montrer DDAH2 Protéines) II and this is involved in the increased ADMA levels that enhance eNOS (Montrer NOS3 Protéines) uncoupling during the development of acute lung injury (ALI).
Ambra1 (Montrer AMBRA1 Protéines) binds to both FAK (Montrer PTK2 Protéines) and Src in cancer cells. When FAK (Montrer PTK2 Protéines) is present, Ambra1 (Montrer AMBRA1 Protéines) is recruited to focal adhesions, promoting FAK (Montrer PTK2 Protéines)-regulated cancer cell direction-sensing and invasion. However, when Ambra1 (Montrer AMBRA1 Protéines) cannot bind to FAK (Montrer PTK2 Protéines), abnormally high levels of phospho-Src and phospho-FAK (Montrer PTK2 Protéines) accumulate at focal adhesions, positively regulating adhesion and invasive migration.
Thus we propose that Cx43 (Montrer GJA1 Protéines) might enhance the activation of Nrf2 (Montrer NFE2L2 Protéines)/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2 (Montrer NFE2L2 Protéines), and then reduce expression of FN, ICAM-1 (Montrer ICAM1 Protéines) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Src overexpression alone activated the Jun N-terminal Kinase (JNK (Montrer MAPK8 Protéines)) signalling pathway to promote actin (Montrer ACTB Protéines) cytoskeletal and cell polarity defects and drive apoptosis in in a whole epithelial tissue context in the Drosophila eye, whereas, in cooperation with RasACT, JNK (Montrer MAPK8 Protéines) led to a loss of differentiation and an invasive phenotype.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (Montrer TMOD4 Protéines) (CP) alphabeta heterodimer, which regulates actin (Montrer ACTB Protéines) filament (F-actin (Montrer ACTB Protéines)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (Montrer MAPK8 Protéines) activation.
Dumbfounded/Neph1 (Montrer NEPH1 Protéines), a key diaphragm constituent, is a target of the Src kinase (Montrer CSK Protéines) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (Montrer NEPH1 Protéines) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A (Montrer PPP2R2B Protéines)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
This study shows that Leu33Pro polymorphism of integrin beta 3 (Montrer ITGB3 Protéines) modulates platelet Src pY418 and focal adhesion kinase pY397 phosphorylation in response to abnormally high shear stress. Whereas physiological shear stress does not affect platelet signaling, abnormally high-shear stress considerably elevates Src and FAK (Montrer PTK2 Protéines) phosphorylation in both Pro33 and Leu33 platelets.
High SRC expression is associated with lung adenocarcinoma.
While activation in c-Src is strictly controlled by ATP-binding and phosphorylation, the authors find that activating conformational transitions are spontaneously sampled in Hsp90 (Montrer HSP90 Protéines)-dependent Src mutants.
High SRC expression is associated with gastric cancer cell migration.
Src kinase (Montrer CSK Protéines) mediates UV-induced TRPV1 (Montrer TRPV1 Protéines) trafficking into cell membrane in HaCaT keratinocytes.
Src and Aurora-A (Montrer AURKA Protéines) interact upon Golgi ribbon fragmentation; Src phosphorylates Aurora-A (Montrer AURKA Protéines) at tyrosine 148 and this specific phosphorylation is required for Aurora-A (Montrer AURKA Protéines) localization at the centrosomes.
Study demonstrated that c-Src contributed to hypoxic microenvironment-rendered paclitaxel resistance in human epithelial ovarian cancer cells by G2/M phase arrest deterioration, and through c-Src suppression, FV-429 was capable of reversing the resistance by blocking c-Src/Stat3 (Montrer STAT3 Protéines)/HIF-1alpha (Montrer HIF1A Protéines) pathway.
Data demonstrated that the Src/Fn14 (Montrer TNFRSF12A Protéines)/NF-kappaB (Montrer NFKB1 Protéines) axis plays a critical role in NSCLC metastasis.
Results suggest that Src promotes EGF (Montrer EGF Protéines)-stimulated EMT (Montrer ITK Protéines) and migration by upregulation of ZEB1 and ZEB2 (Montrer ZEB2 Protéines) through AKT (Montrer AKT1 Protéines) signaling pathway in gastric cancer cells.
RhoA (Montrer RHOA Protéines) and membrane fluidity mediates the spatially polarized Src/FAK (Montrer PTK2 Protéines) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (Montrer TMPRSS5 Protéines)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (Montrer TGFB1 Protéines)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (Montrer PTK2 Protéines)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (Montrer ATP1A1 Protéines) activity and SFK signaling.
Src kinase (Montrer CSK Protéines) mediates hypoxia-induced caspase-1 (Montrer CASP1 Protéines) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (Montrer ATP1A1 Protéines) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase