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anti-Human STAT1 Anticorps:
anti-Mouse (Murine) STAT1 Anticorps:
anti-Rat (Rattus) STAT1 Anticorps:
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Human Monoclonal STAT1 Primary Antibody pour ICS - ABIN1177190
Tanaka, Saito, Kunisawa, Kurashima, Wake, Suzuki, Shultz, Kiyono, Ishikawa: Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. dans Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Polyclonal STAT1 Primary Antibody pour CyTOF, FACS - ABIN4900633
Noser, Mael, Sakuma, Ohmine, Marcato, Lee, Ikeda: The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells. dans Molecular therapy : the journal of the American Society of Gene Therapy 2007
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Human Polyclonal STAT1 Primary Antibody pour WB - ABIN1881847
Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein. dans The Journal of biological chemistry 2010
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Human Polyclonal STAT1 Primary Antibody pour IHC, WB - ABIN361958
Heim: The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. dans Journal of receptor and signal transduction research 1999
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Human Polyclonal STAT1 Primary Antibody pour IF (p), IHC (p) - ABIN674889
Wang, Wang, Song, Chu, Qu: Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. dans Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015
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Human Polyclonal STAT1 Primary Antibody pour IHC - ABIN967087
Schindler, Fu, Improta, Aebersold, Darnell: Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. dans Proceedings of the National Academy of Sciences of the United States of America 1992
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Human Monoclonal STAT1 Primary Antibody pour ICS - ABIN1177187
Townsend, Scarabelli, Davidson, Knight, Latchman, Stephanou: STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. dans The Journal of biological chemistry 2004
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Human Monoclonal STAT1 Primary Antibody pour ICS - ABIN1177188
Varinou, Ramsauer, Karaghiosoff, Kolbe, Pfeffer, Müller, Decker: Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. dans Immunity 2003
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Human Monoclonal STAT1 Primary Antibody pour IHC (p), IP - ABIN269146
Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation. dans International journal of molecular medicine 2003
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Human Polyclonal STAT1 Primary Antibody pour ELISA, ICC - ABIN6255991
Liu, Wu, Zhu, Li, Liu: IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species. dans International immunopharmacology 2018
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These results demonstrated that the IFNGinduced immunosuppressive properties of B7H1 (Montrer CD274 Anticorps) in human BM and WJMSCs were mediated by STAT1 signaling, and not by PI3K (Montrer PIK3CA Anticorps)/RACalpha (Montrer AKT1 Anticorps) serine/threonineprotein kinase signaling
STAT1 plays a pivotal role as a tumor suppressor in glioma.
the present study revealed a negative correlation between the expression of the STAT-1 gene and the glioma grade, as well as between STAT-1 and mutant p53 (Montrer TP53 Anticorps) expression. The negative correlation between STAT-1 and the pathological level of glioma suggested that STAT-1 may be associated with the occurrence and development of glioma, and may be a diagnostic biomarker and therapeutic target for the malignancy of glioma.
PARP9 (Montrer PARP9 Anticorps) and PARP14 (Montrer PARP14 Anticorps) regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4 (Montrer IL4 Anticorps); PARP14 (Montrer PARP14 Anticorps) silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 (Montrer STAT6 Anticorps) phosphorylation in M(IL-4 (Montrer IL4 Anticorps)) cells
PVT1 interacts with STAT1 to inhibit IFN-alpha signaling and tumor cells proliferation.
STAT1 is associated with giant cell tumor of bone recurrence, which might serve as biomarker for giant cell tumor of bone recurrence
High STAT1 expression is associated with head and neck squamous cell carcinoma.
The research described here specifies where in the JAK (Montrer JAK3 Anticorps)/STAT signaling cascade the IFN response is inhibited and which protein domain of nsP2 (Montrer RTN2 Anticorps) is responsible for IFN inhibition. The results illuminate new aspects of antiviral defense and CHIKV counterdefense strategies and will direct the search for novel antiviral compounds.
These results reveal that STAT1 pS727 regulates growth and differentiation in JAK (Montrer JAK3 Anticorps)-STAT activated neoplasms and suggest that Mediator kinase inhibition represents a therapeutic strategy to regulate JAK (Montrer JAK3 Anticorps)-STAT signaling
Transcription factor STAT1 regulates the expression of LINC00174
STAT1 binds to the IL-22 (Montrer IL22 Anticorps) promoter and directly antagonizes STAT3 (Montrer STAT3 Anticorps)-mediated IL-22 (Montrer IL22 Anticorps) induction.
Downregulated SOCS1 (Montrer SOCS1 Anticorps) expression activates the JAK1 (Montrer JAK1 Anticorps)/STAT1 pathway and promotes polarization of macrophages into M1 type.
The Lipopolysaccharide and IFN-beta (Montrer IFNB1 Anticorps)-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn(2+) with the membrane permeable chelator N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.
The possibility that the Gas6 (Montrer GAS6 Anticorps)-Mer (Montrer ERH Anticorps)-PI3K/Akt (Montrer AKT1 Anticorps)-STAT1-LXR (Montrer NR1H3 Anticorps)-Arg2 (Montrer ARG2 Anticorps) pathway plays an essential role for resolving inflammatory response in acute lung injury.
The results of this study strongly indicated that release of interferons by neuronal cells expressing polyglutamine-TBP (Montrer TBP Anticorps) leads to induction of STAT1 and consequent downregulation of miR (Montrer MLXIP Anticorps)-29a/b by a series of cell signaling events.
STAT1 is required to protect B cell development during murine norovirus infection.
Rigidity plays a key role in the toxicity of multi-walled carbon nanotubes and results in increased inflammatory, immunologic, and fibrogenic effects in the lung. STAT1 is an important protective factor in the fibroproliferative response to rMWCNTs, regulating both induced TGF-beta1 (Montrer TGFB1 Anticorps) production and Smad2 (Montrer SMAD2 Anticorps)/3 phosphorylation status.
these results confirmed that myricitrin exhibited anti-inflammatory activity by blocking the activation of JAKs and the downstream transcription factor STAT1, which may result from the downregulation of NOX2 (Montrer CYBB Anticorps)-dependent ROS (Montrer ROS1 Anticorps) production mediated by myricitrin.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (Montrer JAK3 Anticorps)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (Montrer STAT2 Anticorps) nuclear translocation.
Nsp1beta inhibits interferon-activated (Montrer MNDA Anticorps) STAT1/STAT2 (Montrer STAT2 Anticorps) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (Montrer GHRL Anticorps) on ovarian cell functions.
the majority of the STAT1/STAT2 (Montrer STAT2 Anticorps)/IRF9 (Montrer IRF9 Anticorps) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (Montrer CASP8 Anticorps) mRNA levels is associated with phosphorylation of STAT-1 at Ser (Montrer SIGLEC1 Anticorps)-727 and STAT1 binding to the caspase-8 (Montrer CASP8 Anticorps) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (Montrer CISH Anticorps) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (Montrer IL6 Anticorps) (IL), in the presence of its soluble receptor (Montrer IFNAR1 Anticorps) (sIL (Montrer STIL Anticorps)-6R), induces activation of JAK1 (Montrer JAK1 Anticorps), JAK2 (Montrer JAK2 Anticorps), and STAT1/STAT3 (Montrer STAT3 Anticorps) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (Montrer CSN2 Anticorps) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (Montrer STAT2 Anticorps).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 1
, signal transducer and activator of transcription 4
, transcription factor ISGF-3
, activator of transcription
, signal transduction
, LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription 1, 91kDa
, signal transduction and activation of transcription 1
, signal transduction and activation of transcription 1a