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anti-Mouse (Murine) STAT3 Anticorps:
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN3043299
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. dans Molecular medicine reports 2014
Show all 14 Pubmed References
Human Polyclonal STAT3 Primary Antibody pour IHC, WB - ABIN361960
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation. dans Toxicology 2006
Show all 9 Pubmed References
Human Polyclonal STAT3 Primary Antibody pour IHC (p), WB - ABIN6652045
Fan, Ballou, Lin: Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq. dans The Journal of biological chemistry 2003
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Human Polyclonal STAT3 Primary Antibody pour ICC, IHC (p) - ABIN3044166
Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. dans BioMed research international 2013
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN5518872
Wan, Ma, Mei, Shan: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. dans Journal of experimental & clinical cancer research : CR 2010
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Human Polyclonal STAT3 Primary Antibody pour IF, IHC - ABIN361962
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ... dans Cell biology international 2007
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Human Polyclonal STAT3 Primary Antibody pour FACS, IF (p) - ABIN732638
Yang, Sun, Sun, Qi: Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte. dans Molecular biology reports 2012
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN6713922
Zeng, Wang, Dong, Jiang, Tu: Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. dans Phytomedicine : international journal of phytotherapy and phytopharmacology 2014
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Human Polyclonal STAT3 Primary Antibody pour IHC, WB - ABIN6711577
Wang, Deng, Leng, Mao: Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis. dans Molecular immunology 2010
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Ctenopharyngodon idella Polyclonal STAT3 Primary Antibody pour WB - ABIN6711578
Qian, Qian, Zhang, Zhu, Yan, Ye, Peng, Li, Xu, Sun, Xu: 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase. dans Stem cells and development 2012
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findings identify TRPC1 as a modulator of HDM-induced airway remodeling via STAT3-mediated increase in mucus production, which provide new insight in our understanding of the molecular basis of airway remodeling
betaIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.
The expression of CRIF1 in mice with arthritis significantly reduced the number of signal transducer and activator of transcription 3-mediated Th17 cells in the spleen as well as osteoclast differentiation from bone marrow cells.
A moderate high temperature condition at 39 degrees C induces a high lactation capacity of MECs through control of STAT5 and STAT3 signaling.
STAT3-enhancing germline receptor variants contribute to immune evasion through their pleiotropic functions in immune cells.
Study in mouse psoriasis model suggests that Stat3 activation in keratinocytes may impact on Langerhans cell activation in situ via IL-1alpha stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23.
The RNF20-mediated H2Bub1 cooperating with MOF-mediated H4K16ac activates the transcription of Stat3
MiR-125a-3p exerts anti-fibrotic effects in silica-induced pulmonary fibrosis by regulating Fyn/STAT3 signaling.
IL-23 signaled through both STAT3 and STAT4, and disruption in STAT4 signaling impaired CNS autoimmunity independent of IL-12
These results indicate that Stat3 is indispensable for the survival of epithelial cells through the activation of integrin signaling and the downstream FAK pathway; however, it is not required for the Wnt signaling-activated normal or tumor epithelial cells.
Here the authors show that the transcription factor Stat3, a canonical inducer of astrogliosis, is activated in an Alzheimer's disease mouse model and human Alzheimer's disease. Therefore, using a conditional knockout approach, the authors deleted Stat3 specifically in astrocytes in the APP/PS1 model of Alzheimer's disease. They found that Stat3-deficient APP/PS1 mice show decreased beta-amyloid levels and plaque burden.
High STAT3 expression is associated with renal dysfunction, inflammation and fibrosis in Alport syndrome.
Cucurbitacin E ameliorates acute graft-versus-host disease by modulating Th17 cell subsets and inhibiting STAT3 activation.
BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation
These findings imply that regionally distinct patterns of STAT3 phosphorylation in the Sertoli cells depend on either location or spermatogenic activity in normal healthy testes in vivo, highlighting a novel entry point to understanding STAT signaling in mammalian spermatogenesis.
this study demonstrates a previously unrecognized protective role of myeloid cell-specific STAT3 signaling in immune cell-mediated skin fibrosis
Studied effect of Papaver nudicaule extract on reduction of inflammation through inactivating NF-kappaB and signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide treated RAW264.7 cells.
Study provides evidence that Stat3 activity is required for HC11 mammary epithelial cell differentiation.
PRMT1 thus regulates Th17 differentiation by controlling the reciprocal recruitment of STAT3 and STAT5.
Findings indicate excess signal transducer and activator of transcription 3 (STAT3) activity negatively regulated preproopiomelanocortin (POMC) expression in hypothalamus of diet induced obesity (DIO) mice.
Data suggest that targeting the ring finger 6 protein(RNF6)/protein-tyrosine phosphatase SHP-1 (SHP-1)/signal transducer and activator of transcription 3 (STAT3) axis provides a potential therapeutic option for RNF6-amplified tumors.
Our data suggest that MKP1 expression can be differentially regulated by p38, JNK, and the TBK1-JAK2-STAT3 pathway after activation of toll-like receptor 4 (TLR4)
YAP interacts with STAT3 to promote the phosphorylation, nuclear translocation and VEGF transcription of STAT3, hence facilitates the proliferation, migration and tube formation of retinal microvascular endothelial cells.
Findings indicate the importance of the signal transducer and activator of transcription 3 (STAT3)/miR-200 family axis in early stage of disease.
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.
PAG1 conferred inherent radioresistance by activating STAT3.
NEAT1 can act as a competing endogenous lncRNA (ceRNA) to regulated STAT3 by sponging miR-485 in HCC.
MALAT1can act as a competing endogenous lncRNA (ceRNA) to modulate miR-124/STAT3 in NSCLC.
SOX11 regulation by the cell-cycle regulator cyclin D1 (CCND1) and the signal transducer and activator of transcription 3 (STAT3), in mantle cell lymphoma is reported.
Knockdown of STAT3 did not affect basal proliferation, but reduced sphere forming capacity of two human melanoma cell lines. Moreover, the level of active STAT3 was elevated in rhodamine 123 negative subpopulations of CSCs sorted from three melanoma cell lines.
The STAT3 pathway promotes hepatocellular carcinoma (HCC) progression from two important aspects, stimulating the proliferation of HCC cells via VEGF/VEGFR positive feedback loop and VEGF secreted by HCC in turn promoting the proliferation, migration and tubulogenesis of endothelial cells again via STAT3 activation.
Results suggested that STAT3 activity be requisite for the lung tumorigenesis caused by MVP knockdown.
STAT3 enhances lysosomal acidification by stimulating the ATPase activity of the V1 domain in the assembled V-ATPase complex on the lysosomal membrane.
reactive oxygen species could induce CD80 expression via the JNK and p38 MAPK pathways, that activated STAT3 transcription factor in colon cancer epithelial cells
our findings suggest a tumor suppressing role of TPTEP1 in Hepatocellular carcinoma (HCC) progression and provide a novel understanding of TPTEP1 during the chemotherapy for Hepatocellular carcinoma (HCC).
The miR-1181/STAT3 axis mediated PDGFBB-induced dysfunction in human PASMCs.
STAT3 protein expression is upregulated in human papillary thyroid cancers (PTC) and in thyroid carcinoma cell lines exposed to PLX4032, a BRAF inhibitor, inducing PTC resistance.
Data show that phosphorylated STAT3 could bind to the miR155HG promoter region from - 1548 bp to - 1411 bp upstream of the transcription start site to stimulate miR155HG expression. This suggests that STAT3 phosphorylation is the critical role in driving lncRNAs regulation similar to miR155HG in malignant brain tumor.
Hsa_circ_0068871 regulates the miR-181a-5p/FGFR3 axis and activates STAT3 to promote bladder cancer (BCa) progression, and it may serve as a potential biomarker.
The present results revealed that the JAK3/STAT3 oncogenic pathway and PRDM1 expression could stratify clinicopathologic features of extranodal NK/Tcell lymphoma, nasal type (ENNK/TNT).
variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
role of shear flow in attenuating activation in endothelial cells
peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.
STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.
Data suggest that IL-6 (interleukin 6) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
Osteoarthritis-cartilage injuries are caused by activating JAK2/STAT3 pathway.
This is the first report of the genetic polymorphisms of the JAK1 and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 is required for hepatocyte cell differentiation and liver regeneration.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3