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anti-Mouse (Murine) STAT3 Anticorps:
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN3043299
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. dans Molecular medicine reports 2014
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Human Polyclonal STAT3 Primary Antibody pour IHC, WB - ABIN361960
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation. dans Toxicology 2006
Show all 9 Pubmed References
Human Polyclonal STAT3 Primary Antibody pour WB - ABIN5518872
Wan, Ma, Mei, Shan: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. dans Journal of experimental & clinical cancer research : CR 2010
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN1881850
Li, Cheung, Evans, Shaw: Modulation of gene expression and tumor cell growth by redox modification of STAT3. dans Cancer research 2010
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Human Polyclonal STAT3 Primary Antibody pour IHC (p), WB - ABIN389665
Schick, Oakeley, Hynes, Badache: TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. dans The Journal of biological chemistry 2004
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Human Polyclonal STAT3 Primary Antibody pour IHC (p), WB - ABIN6652045
Fan, Ballou, Lin: Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq. dans The Journal of biological chemistry 2003
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Human Polyclonal STAT3 Primary Antibody pour IF, IHC - ABIN361962
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ... dans Cell biology international 2007
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Human Polyclonal STAT3 Primary Antibody pour FACS, IF (p) - ABIN732638
Yang, Sun, Sun, Qi: Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte. dans Molecular biology reports 2012
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Human Monoclonal STAT3 Primary Antibody pour FACS, ICC - ABIN4898974
Bruhn, Townsend, Khoon Lee, Shivasami, Price, Wrin, Arentz, Tebbutt, Hocking, Cunningham, Hardingham: Proangiogenic tumor proteins as potential predictive or prognostic biomarkers for bevacizumab therapy in metastatic colorectal cancer. dans International journal of cancer 2014
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Human Polyclonal STAT3 Primary Antibody pour WB - ABIN6713922
Zeng, Wang, Dong, Jiang, Tu: Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. dans Phytomedicine : international journal of phytotherapy and phytopharmacology 2014
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These findings imply that regionally distinct patterns of STAT3 phosphorylation in the Sertoli cells depend on either location or spermatogenic activity in normal healthy testes in vivo, highlighting a novel entry point to understanding STAT signaling in mammalian spermatogenesis.
this study demonstrates a previously unrecognized protective role of myeloid cell-specific STAT3 signaling in immune cell-mediated skin fibrosis
Studied effect of Papaver nudicaule extract on reduction of inflammation through inactivating NF-kappaB and signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide treated RAW264.7 cells.
Study provides evidence that Stat3 activity is required for HC11 mammary epithelial cell differentiation.
PRMT1 thus regulates Th17 differentiation by controlling the reciprocal recruitment of STAT3 and STAT5.
Findings indicate excess signal transducer and activator of transcription 3 (STAT3) activity negatively regulated preproopiomelanocortin (POMC) expression in hypothalamus of diet induced obesity (DIO) mice.
Results indicate that dopamine receptor D5 (DRD5)-signalling in dendritic cells (DCs) was mediated through the attenuation of signal transducer and activator of transcription 3 (STAT3)-activation.
Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation.
miR-151-3p inhibited lipopolysaccharide-induced IL-6 production by targeting Stat3.
DLX3 is a critical regulator of STAT3 signaling network that maintains skin homeostasis.
Stat3 conditional knockout adult mice were significantly resistant to collagen-induced arthritis.
STAT3 inhibition caused significant reduction of tumor burden as well as liver-associated myeloid-derived suppressor cells (L-MDSC) due to decrease in pSTAT3 levels. STAT3 inhibition activated apoptotic signaling pathways in L-MDSC, upregulating pro-apoptotic proteins and FAS, while down-regulating Bcl-2 and pro-survival proteins. This is a previously unrecognized link between STAT3 inhibition and MDSC FAS apoptosis.
FLLL32, a small molecule inhibitor of JAK2/STAT3 signaling, reduces neurofibroma growth in mice.
These data underscore a critical sex-specific role for epithelial Stat3 signaling in K-ras mutant Lung adenocarcinomas.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.
Promoter regions of ZO-1 and SOCS3 were directly regulated by transcriptional activation of STAT3. These findings suggest that regulation of the STAT3 pathway is essential for corneal endothelial homeostasis via barrier function and may protect from various inflammatory factors.
Denervation-activated fibro-adipogenic progenitors exhibited persistent STAT3 activation and secreted elevated levels of IL-6, which promoted muscle atrophy and fibrosis.
B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.
the absence of epithelial Stat3 in mice leads to delayed incisor amelogenesis.
Study found that by promoting the phosphorylation of Stat3 Pim-3 induced the expression of Slug, Snail, and Zeb1, which enhanced epithelial-mesenchymal transition-related changes and induced melanoma migration and invasion. Exploration of the mechanism revealed that Pim-3 bound directly to Stat3 and promoted its phosphorylation.
reveals a new role of mitochondrial Stat3 in preventing ASK1/p38(MAPK)-mediated apoptosis.
a crucial role of STAT3 in regulating the epigenetic status of T cells in Latent autoimmune diabetes of adults (LADA).
In the hypopharyngeal squamous cell carcinoma (HSCC) samples, low AIM2 expression was closely related to lymph node metastasis and intravascular tumor thrombus and were strongly associated with poor survival. AIM2 expression was negatively correlated with pSTAT3 expression in the HSCC tissue samples, and combined analysis revealed that patients with low AIM2 and high pSTAT3 levels had the worst survival rate.
The present results indicate that activation of the IL-6/STAT3 pathway contributes to the pathogenesis of thromboangiitis obliterans (TAO) by regulating cellular adhesion molecules and cytoskeleton of vascular endothelial cells.
The molecules inhibit STAT3 by interacting with its SH2 domain.
IL-6, TNF-alpha production, SOCS3 mRNA expression were downregulated, while miR-196b-5p and STAT3 mRNA expression were upregulated in monocytes from long-term cigarette smoking-related pulmonary tuberculosis patients as compared to nonsmoking pulmonary tuberculosis patients.
Gene alteration and protein expression of PD-L1 and phosphor STAT3 expression were closely related in diffuse large B cell lymphoma.
MAZ is a potential therapeutic target to dampen STAT3 signaling in colon cancer.
Acetyl-Src translocates into nuclei, where it forms the Src-STAT3 enhanceosome for gene regulation.
MDA-9/Syntenin physically interacted with insulin-like growth factor-1 receptor following treatment with insulin-like growth factor binding protein-2 (IGFBP2), regulating downstream signaling processes that enabled STAT3 phosphorylation.
Results show that the level of STAT3 phosphorylation is significantly upregulated in diabetic cardiomyopathy.
MerTK mediates STAT3-KRAS/SRC-signaling axis for glioma stem cell maintenance
CASC11 was found to be activated by the transcription factor STAT3 in hepatocellular carcinoma cells
the results of the present study indicated that lncRNA H19/miR29b3p/STAT3 signaling was involved in the development of lung adenocarcinoma
High STAT3 expression is associated with colon cancer.
High STAT3 expression is associated with lymph node metastasis and intrahepatic metastasis in Gallbladder Cancer.
The results of the present study demonstrated that EPDMNQ and ENDMNQ induced apoptosis through ROSmodulated MAPK and STAT3 signaling pathways in Hep3B cells. Therefore, these novel 1,4naphthoquinone derivatives may be useful as anticancer agents for the treatment of liver cancer.
we review the role of IL-6/JAK/STAT3 signalling in the tumour microenvironment and the status of preclinical and clinical investigations of agents targeting this pathway. We also discuss the potential of combining IL-6/JAK/STAT3 inhibitors with currently approved therapeutic agents directed against immune-checkpoint inhibitors.
this study reports that eosinophilia and reduced STAT3 signaling affect neutrophil cell death in autosomal-dominant Hyper-IgE syndrome
This work has elucidated a novel mechanism of TNK2-AS1-mediated angiogenesis by enforcing STAT3/VEGFA signaling.
variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
role of shear flow in attenuating activation in endothelial cells
peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.
STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.
Data suggest that IL-6 (interleukin 6) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
Osteoarthritis-cartilage injuries are caused by activating JAK2/STAT3 pathway.
This is the first report of the genetic polymorphisms of the JAK1 and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 is required for hepatocyte cell differentiation and liver regeneration.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3