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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. dans Molecular cancer 2014
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STAT3 restrained cytotoxic gene expression in CD8 (Montrer CD8A Protéines)+ T cells responding to viral infection in vivo.
STAT3 signalling in myeloid cells is deleterious in the control of infection with Mycobacterium tuberculosis.
It has been observed that PTEN expression downregulated by p53 (Montrer TP53 Protéines) deficiency induced the activation of STAT3 in autoimmune arthritis.
The therapeutic function of HtrA2 (Montrer HTRA2 Protéines) in inflammatory diseases is linked with Th17 development and the STAT3 pathway in splenocytes.
Our data suggest that HO-1 (Montrer HMOX1 Protéines) exerts its inhibitory effect on Th17 cell differentiation by directly associating and blocking STAT3 phosphorylation. We speculate that hemin may be a potential therapeutic candidate for the treatment of other types of immune and pulmonary inflammatory-related diseases.
reduced expression of STAT3 in myeloid cells from the hosts, but not the donors, increased inflammation, increased donor T cell activation, and exacerbated GVHD demonstrating that STAT3 in host myeloid cells, such as macrophages, dampens acute GVHD.
Suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription (Montrer STAT1 Protéines)/epidermal growth factor receptor (Montrer EGFR Protéines) inhibition for cancer treatment with respect to cardiotoxity.
STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for hepatocellular carcinoma inhibition and biliary regeneration.
Smad7 (Montrer SMAD7 Protéines) enables STAT3 activation and promotes pluripotency independent of TGF-beta (Montrer TGFB1 Protéines) signaling.
Reg3g (Montrer REG3g Protéines) acts as an immunosuppressive promoter by activating the JAK2 (Montrer JAK2 Protéines)/STAT3 signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
STAT3 regulates angiogenic and metabolic pathways before HIF1alpha (Montrer HIF1A Protéines), suggesting that HIF1alpha (Montrer HIF1A Protéines) is not the initiating trans-acting factor in the response of pericytes to ischemia.
we revisited the question of the relationship between Cav1 (Montrer CAV1 Protéines) and Stat3-ptyr705 in non-transformed mouse fibroblasts and in human lung carcinoma cells, by examining their effect at different cell densities.Our results demonstrate that Cav1 (Montrer CAV1 Protéines) downregulates cadherin-11, by a mechanism which requires the Cav1 (Montrer CAV1 Protéines) scaffolding domain. This cadherin-11 downregulation, leads to a reduction in cRac1 and Stat3 activity levels.
the effect of the STAT3 inhibitor SH-4-54 on GBM migration and survival. SH-4-54 inhibited STAT3 activity and reduced 3D migration and survival of GBM43 but had no effect on GBM10.
miR (Montrer MLXIP Protéines)-124, IL-6R and STAT3 are involved in the process of sulforaphane-improved CDDP chemotherapy efficacy by targeting cancer stem cell-like properties
This analysis indicated that corilagin is mainly involved in the glycolysis pathway. Seahorse (Montrer LRRC6 Protéines) XF96 extracellular acidification rate analysis confirmed that corilagin inhibited glycolysis by downregulation of CD44 (Montrer CD44 Protéines) and STAT3
Our findings revealed that B7-H3 (Montrer CD276 Protéines) affect ovarian cancer progression through the Jak2 (Montrer JAK2 Protéines)/Stat3 pathway, indicating that B7-H3 (Montrer CD276 Protéines) has the potential to be a useful prognostic marker.
Studied the role of ZEB1-AS1 (Montrer PTGDR Protéines), and it's association with IL-11 (Montrer IL11 Protéines), in promoting STAT3 activation in B-lymphoblastic leukemia.
that loss of RIP4 (Montrer RIPK4 Protéines) enhances STAT3 signaling in lung cancer cells
Studied effect of carfilzomib and doxorubicin on IL-6 (Montrer IL6 Protéines), pSTAT-3 and NF-kB Activity in MDA-MB-231 Breast Cancer Cells.
Amorfrutin A is a potent inhibitor of STAT3.
Thus, activation of STAT3 and inactivation of AKT (Montrer AKT1 Protéines) signaling are involved in structural regression of the corpus luteum.
STA3 (Montrer ARHGEF3 Protéines) facilitates TLR4 (Montrer TLR4 Protéines)-dependent IL-6 (Montrer IL6 Protéines) and IL-8 (Montrer IL8 Protéines) production via IL-6 (Montrer IL6 Protéines) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (Montrer IL6 Protéines) (IL), in the presence of its soluble receptor (Montrer IFNAR1 Protéines) (sIL-6R), induces activation of JAK1 (Montrer JAK1 Protéines), JAK2 (Montrer JAK2 Protéines), and STAT1 (Montrer STAT1 Protéines)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (Montrer VEGFA Protéines) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (Montrer NOX1 Protéines)-mediated activation of STAT3.
In porcine circovirus type 2 subclinical infection, SOCS3 (Montrer SOCS3 Protéines) interacted with STAT3 and TNF receptor-associated factor 2 (Montrer TRAF2 Protéines), suggesting mechanisms by which SOCS3 (Montrer SOCS3 Protéines) inhibits IL-6 (Montrer IL6 Protéines) and TNF-alpha (Montrer TNF Protéines) signaling.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (Montrer CCND2 Protéines) and PSEN1 (Montrer PSEN1 Protéines) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (Montrer LIF Protéines) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (Montrer FTH1 Protéines)-supplemented media.
Data suggest that IL-6 (interleukin 6 (Montrer IL6 Protéines)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (Montrer IL6 Protéines)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (Montrer JAK1 Protéines) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF (Montrer VEGFA Protéines) pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (Montrer MMP2 Protéines) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (Montrer CDC25A Protéines) expression during oogenesis. Accordingly, restoring Cdc25a (Montrer CDC25A Protéines) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (Montrer PTPN9 Protéines) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (Montrer GATA1 Protéines) and ZBP-89 (Montrer ZNF148 Protéines).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (Montrer SOCS3 Protéines) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (Montrer RAB1A Protéines) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (Montrer PRCP Protéines) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3