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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. dans Molecular cancer 2014
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virus infection with enterovirus 71 and H1N1 PR8 influenza virus results in increased FPR2 (Montrer FPR2 Protéines) expression. Inhibition of STAT3 phosphorylation in virus-infected cells repressed the induction of FPR2 (Montrer FPR2 Protéines), which led to a reduction in viral loads.
HO-1 (Montrer HMOX1 Protéines) enhanced STAT3 phosphorylation, which enriched to Il12b (Montrer IL12B Protéines) and Il23a (Montrer IL23A Protéines) loci and negatively regulated their transcription. These findings demonstrate the underlying mechanism through which a nutritional can interfere with the immune response. CUR silences IL-23 (Montrer IL23A Protéines)/Th17-mediated pathology by enhancing HO-1 (Montrer HMOX1 Protéines)/STAT3 interaction in dendritic cells.
these data suggest that aloin attenuated LPSinduced inflammation by inhibiting ROSmediated activation of the JAK1STAT1/3 signalling pathway, thereby inhibiting the nuclear translocation of STAT1 (Montrer STAT1 Protéines)/3 in RAW264.7 cells.
Stat3 role in the the ureter obstruction induced renal fibrosis.
p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in unilateral urethral obstruction (Montrer TP53 Protéines).
The expression of STAT3 in J774A.1 cells confirmed that these cells are M2 macrophage. Moreover, silencing of STAT3 by siRNA delivery using oligofectamine delivery suggests that siRNA delivery using vehicles like nanoliposome could be a useful therapeutic agent in M2 macrophage therapy and its switch to M1 macrophages
These findings indicate that embelin inhibits abdominal aortic aneurysm through decreasing IL6induced STAT3, and NFkappaB inactivation.
Protective role for STAT3 in the hematopoietic system is mediated by STAT3-dependent restraint of excessive proinflammatory signaling via Ubc13 (Montrer UBE2N Protéines) modulation.
The authors conclude that Mycobacterium tuberculosis ESAT-6 stimulates macrophage IL-6 (Montrer IL6 Protéines) production through STAT3 activation.
These results suggest that the inhibition of IL6 (Montrer IL6 Protéines)/STAT3 signaling is a potential mechanism by which PZH is used in the treatment of ulcerative colitis.
a transcription-independent mechanism for Stat3-mediated centrosome clustering that involves Stathmin, a Stat3 interactor involved in microtubule depolymerization, and the mitotic kinase PLK1, is reported.
This review discusses the upstream activators of STAT3 in skeletal muscles, with a focus on interleukin 6 (IL6 (Montrer IL6 Protéines)) and transforming growth factor beta 1 (TGF-beta1 (Montrer TGFB1 Protéines)).
High STAT3 expression is associated with lung adenocarcinoma.
JAK2 (Montrer JAK2 Protéines) and STAT3 are activated in Idiopathic pulmonary fibrosis
The results reveal that the EGF (Montrer EGF Protéines)-STAT3 signaling pathway promotes and maintains colorectal cancer (CRC (Montrer CALR Protéines))stemness. In addition, a crosstalk between STAT3 and Wnt (Montrer WNT2 Protéines) activates the Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signaling pathway, which is also responsible for cancer stemness. Thus, STAT3 is a putative therapeutic target for CRC (Montrer CALR Protéines) treatment.
MiR (Montrer MLXIP Protéines)-29a down-regulation is correlated with drug resistance of nasopharyngeal carcinoma cell line CNE-1 and MiR (Montrer MLXIP Protéines)-29a up-regulation decreases Taxol resistance of nasopharyngeal carcinoma CNE-1 cells possibly via inhibiting STAT3 and Bcl-2 (Montrer BCL2 Protéines) expression.
Kidney biopsies from patients with IgA nephropathy and diabetic nephropathy exhibited substantial activation of p53 (Montrer TP53 Protéines) and STAT3, decreased expression of SOCS7, and increase in profibrotic proteins and miR (Montrer MLXIP Protéines)-199a-3p.
Low-dose radiation decreases tumor progression via the inhibition of the JAK1 (Montrer JAK1 Protéines)/STAT3 signaling axis in breast cancer cell lines and in a mouse xenograft model.
High STAT3 expression is associated with cell growth, aggressiveness, metastasis in gastric cancer.
High expression of iNOS (Montrer NOS2 Protéines) and STAT3 in cells transfected with miR (Montrer MLXIP Protéines)-34a mimic further validated it.
variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
Thus, activation of STAT3 and inactivation of AKT (Montrer AKT1 Protéines) signaling are involved in structural regression of the corpus luteum.
STA3 (Montrer ARHGEF3 Protéines) facilitates TLR4 (Montrer TLR4 Protéines)-dependent IL-6 (Montrer IL6 Protéines) and IL-8 (Montrer IL8 Protéines) production via IL-6 (Montrer IL6 Protéines) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (Montrer IL6 Protéines) (IL), in the presence of its soluble receptor (Montrer IFNAR1 Protéines) (sIL-6R), induces activation of JAK1 (Montrer JAK1 Protéines), JAK2 (Montrer JAK2 Protéines), and STAT1 (Montrer STAT1 Protéines)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (Montrer VEGFA Protéines) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (Montrer NOX1 Protéines)-mediated activation of STAT3.
STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning
In porcine circovirus type 2 subclinical infection, SOCS3 (Montrer SOCS3 Protéines) interacted with STAT3 and TNF receptor-associated factor 2 (Montrer TRAF2 Protéines), suggesting mechanisms by which SOCS3 (Montrer SOCS3 Protéines) inhibits IL-6 (Montrer IL6 Protéines) and TNF-alpha (Montrer TNF Protéines) signaling.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (Montrer CCND2 Protéines) and PSEN1 (Montrer PSEN1 Protéines) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (Montrer LIF Protéines) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (Montrer FTH1 Protéines)-supplemented media.
Data suggest that IL-6 (interleukin 6 (Montrer IL6 Protéines)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (Montrer IL6 Protéines)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
Osteoarthritis-cartilage injuries are caused by activating JAK2 (Montrer JAK2 Protéines)/STAT3 pathway.
This is the first report of the genetic polymorphisms of the JAK1 (Montrer JAK1 Protéines) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF (Montrer VEGFA Protéines) pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (Montrer MMP2 Protéines) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (Montrer CDC25A Protéines) expression during oogenesis. Accordingly, restoring Cdc25a (Montrer CDC25A Protéines) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (Montrer PTPN9 Protéines) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (Montrer GATA1 Protéines) and ZBP-89 (Montrer ZNF148 Protéines).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (Montrer SOCS3 Protéines) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (Montrer RAB1A Protéines) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (Montrer PRCP Protéines) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3