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anti-Human CACNA2D2 Anticorps:
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Human Polyclonal CACNA2D2 Primary Antibody pour WB - ABIN550315
Kim, Kim, Lee, King, Chin: Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit. dans Proceedings of the National Academy of Sciences of the United States of America 1992
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Human Monoclonal CACNA2D2 Primary Antibody pour IF, ELISA - ABIN522733
Pippucci, Parmeggiani, Palombo, Maresca, Angius, Crisponi, Cucca, Liguori, Valentino, Seri, Carelli: A novel null homozygous mutation confirms CACNA2D2 as a gene mutated in epileptic encephalopathy. dans PLoS ONE 2013
show that the action of alpha2delta2 on tumor development occurs not only through a stimulation of proliferation
The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported.
CACNA2D2 deletion/methylation is associated with cervical disease progression.
single nucleotide polymorphism identified
role in apoptosis in non-small cell lung cancer cells via association with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity
In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans.
Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression.
Cacna2d2 is a developmental switch that limits axon growth and regeneration. Cacna2d2 gene deletion or silencing promoted axon growth in vitro.
Inner hair cells possess calcium channels that are essential for transmitting sound information into synaptic transmitter release. Voltage-gated calcium channels can coassemble with auxiliary subunit alpha2delta isoforms 1-4. We found that hair cells of the mouse express the auxiliary subunit alpha2delta2, which is needed for normal hearing thresholds. Using a mouse model with a mutant, nonfunctional alpha2delta2 prote...
all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.
We show that both mRNA and protein corresponding to this predicted transcript are expressed in du/du cerebellum and present in Purkinje cells
Cacna2d2 has a role in epilepsy and ataxia
Both alpha2delta-2 and CaV2.1 are normally associated with cholesterol-rich microdomains, and this influences their functionality.
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
alpha 2 delta calcium channel subunit
, gene 26
, voltage-dependent calcium channel subunit alpha-2/delta-2
, voltage-gated calcium channel subunit alpha-2/delta-2
, protein ducky
, calcium channel, voltage dependent, alpha2/delta subunit 2