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Mouse (Murine) Monoclonal UNC13A Primary Antibody pour IP, ELISA - ABIN1742276
Martín, Durroux, Ciruela, Torres, Pin, Sánchez-Prieto: The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. dans The Journal of biological chemistry 2010
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Human Polyclonal UNC13A Primary Antibody pour ICC, IP - ABIN1742277
Rinetti, Schweizer: Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
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This study demonstrated that the population specific rare variants of UNC13A may modulate survival in ALS in United kingdom.
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder
UNC13A rs12608932 is a risk factor for ALS and a modifying factor for survival and disease progression rate in a Spanish cohort.
Munc13-1, on account of its role in both insulin and neurotransmitter exocytosis and through its binding properties, may be an important factor contributing to the development or progression of diabetic neuropathy.
UNC13A provides a novel link between amyotrophic lateral sclerosis and frontotemporal dementia and identifies changes in neurotransmitter release and synaptic function as a converging mechanism in the pathogenesis of ALS and FTD-TDP.
CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1.
This study demonistrated that UNC13A influences survival in Italian amyotrophic lateral sclerosis patients.
Our results further corroborate the role of UNC13A in amyotrophic lateral sclerosis pathogenesis.
Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
Results do not provide evidence of an association between a variant in the UNC13A gene and susceptibility to sporadic Amyotrophic lateral sclerosis in a French homogeneous population.
rs12608932 Single Nucleotide Polymorphism is located at 19p13.3 and maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters such as glutamate at neuromuscular synapses.
Data suggest that the Munc13-1/2 heterodimer is an active component of the vesicle docking, priming and release complex.
Rab37 interacts with Munc13-1 to control TNF-alpha secretion from activated macrophages
These results indicate that synaptic vesicle docking at the plasma membrane and functional priming are respective morphological and physiological manifestations of the same molecular process mediated by SNARE complexes and Munc13-1/2s.
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.
protein unc-13 homolog A